1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-020-00829-x</a>
ISSN
2190-3948 2190-393X
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s13346-020-00829-x</a>
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Overcoming barriers confronting application of protein therapeutics in bone fracture healing.
Publisher
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Drug delivery and Translational Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-11
Subject
The topic of the resource
Osteoporosis; Drug delivery; Implants; Bone regeneration; Osteoinductive proteins; Osteopenia
Creator
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Czech T; Oyewumi MO
Description
An account of the resource
Bone fracture is a major contributor to debilitation and death among patients with bone diseases. Thus, osteogenic protein therapeutics and their delivery to bone have been extensively researched as strategies to accelerate fracture healing. To prevent morbidity and mortality of fractures, which occur frequently in the aging population, there is a critical need for development of first-line therapeutics. Bone morphogenic protein-2 (BMP-2) has been at the forefront of bone regeneration research for its potent osteoinduction, despite safety concerns and biophysiological obstacles of delivery to bone. However, continued pursuit of osteoinductive proteins as a therapeutic option is largely aided by drug delivery systems, playing an imperative role in enhancing safety and efficacy. In this work, we highlighted several types of drug delivery platforms and their biomaterials, to evaluate the suitability in overcoming challenges of therapeutic protein delivery for bone regeneration. To showcase the clinical considerations for each type of platform, we have assessed the most common route of administration strategies for bone regeneration, classifying the platforms as implantable or injectable. Additionally, we have analyzed the commonly utilized models and methodology for safety and efficacy evaluation of these osteogenic protein-loaded systems, to present clinical opinions for future directions of research in this field. It is hoped that this review will promote research and development of clinically translatable osteogenic protein therapeutics, while targeting first-line treatment status for achieving desired outcomes of fracture healing. Graphical abstract.
Identifier
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<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">10.1007/s13346-020-00829-x</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
August 2020 List
Bone regeneration
Czech T
Department of Pharmaceutical Sciences
Drug delivery
Drug delivery and translational research
Implants
journalArticle
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Osteoinductive proteins
osteopenia
Osteoporosis
Oyewumi MO
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/BRS.0b013e3181b0b789" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/BRS.0b013e3181b0b789</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1995-1999
Issue
18
Volume
34
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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A Simple Radiological Method For Recognizing Osteoporotic Thoracic Vertebral Compression Fractures And Distinguishing Them From Scheuermann Disease
Publisher
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Spine
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
compression fracture; deformities; diagnosis; disease; kyphosis; Neurosciences & Neurology; Orthopedics; osteopenia; osteoporosis; population; Scheuermann; spine radiology; trial; vertebral fracture; women
Creator
An entity primarily responsible for making the resource
Masharawi Y; Rothschild B; Peled N; Hershkovitz I
Identifier
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<a href="http://doi.org/10.1097/BRS.0b013e3181b0b789" target="_blank" rel="noreferrer noopener">10.1097/BRS.0b013e3181b0b789</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
compression fracture
deformities
Diagnosis
Disease
Hershkovitz I
Kyphosis
Masharawi Y
Neurosciences & Neurology
Orthopedics
osteopenia
Osteoporosis
Peled N
Population
Rothschild B
Scheuermann
Spine
spine radiology
trial
vertebral fracture
Women