1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
264–271
Issue
1
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.
Publisher
An entity responsible for making the resource available
International journal of clinical and experimental pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Adult; Female; Humans; Middle Aged; Aged; Young Adult; Immunohistochemistry; Neoplasm Staging; Prognosis; Kaplan-Meier Estimate; Up-Regulation; Biomarkers; beta-catenin; beta Catenin/analysis/*biosynthesis; Cyclin D1/analysis/*biosynthesis; cyclinD1; Ovarian Neoplasms/*metabolism/mortality/pathology; ovarian serous carcinoma; prognosis; Cystadenocarcinoma; Serous/*metabolism/mortality/pathology; Tumor/*analysis
Creator
An entity primarily responsible for making the resource
Wang Hai; Wang Haiyan; Makki Mohammad Shahidul; Wen Juanjuan; Dai Yingqing; Shi Qunli; Liu Qi; Zhou Xiaojun; Wang Jiandong
Description
An account of the resource
UNLABELLED: Ovarian serous cancer is the most common subtype of epithelial ovarian cancer, and is the leading cause of death from gynecologic cancer. There is an important need for exploration of diagnostic and prognostic markers for this disease. beta-catenin and cyclinD1 play central roles in the tumorigenesis for certain cancers. The role of beta-catenin and cyclinD1 in diagnosis and prognosis of ovarian serous carcinoma is uncertain. In the present study, the expression of beta-catenin and cyclinD1 was examined in 60 ovarian serous carcinomas patients with immunohistochemical staining. The relationship between expression of beta-catenin and cyclinD1 and FIGO stage, pathological grade was analyzed. Kaplan-Meier survival function was used to analyze the prognosis. Overexpression of beta-catenin is more often detected in patients with FIGO stage III and IV than in those with stage I, and II (P=0.003). No significant relationship was found between expression of beta-catenin and pathological grade (P=0.817). Positive expression of beta-catenin related to lower survival rate (P=0.034). The expression of cyclinD1 had no relationship with FIGO stage (P=0.829). Overexpression of cyclinD1 was positively to pathological grade (P=0.017) and survival rate (P=0.009). There is a significantly positive relationship between expression of beta-catenin and cyclinD1 (P=0.014). No statistical significance was found between expression of beta-catenin and cyclinD1 and other pathological parameters. CONCLUSIONS: Expression of beta-catenin and cyclinD1 may be used as predict markers for poor prognosis.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Adult
Aged
beta Catenin/analysis/*biosynthesis
beta-catenin
Biomarkers
Cyclin D1/analysis/*biosynthesis
cyclinD1
Cystadenocarcinoma
Dai Yingqing
Female
Humans
Immunohistochemistry
International journal of clinical and experimental pathology
Kaplan-Meier Estimate
Liu Qi
Makki Mohammad Shahidul
Middle Aged
Neoplasm Staging
Ovarian Neoplasms/*metabolism/mortality/pathology
ovarian serous carcinoma
Prognosis
Serous/*metabolism/mortality/pathology
Shi Qunli
Tumor/*analysis
Up-Regulation
Wang Hai
Wang Haiyan
Wang Jiandong
Wen Juanjuan
Young Adult
Zhou Xiaojun