1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000127236" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000127236</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
181-187
Issue
3
Volume
66
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interactive effects of tamoxifen and estrogen upon the nigrostriatal dopaminergic system
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
breast-cancer; rat; receptors; Neurosciences & Neurology; Endocrinology & Metabolism; catecholamines; breast-cancer; striatum; uptake sites; amphetamine; Progesterone; female cd-1 mice; release; antiestrogens; brain metastases; chronic estradiol; ovarian steroids; sexual-behavior
Creator
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McDermott J L; Anderson L I; Dluzen D E
Description
An account of the resource
Adult female rats were ovariectomized and received a 21-day release pellet containing either (17)beta-estradiol (0.1 mg), tamoxifen (5.0 mg), a combination of estradiol and tamoxifen or no further treatment. At 14 days following ovariectomy +/- hormone treatments rats were sacrificed, the corpus striatum removed and prepared for assessment of dopamine release using in vitro superfusion. Maximal potassium-stimulated dopamine release rates were obtained with the estradiol + tamoxifen-treated rats and these levels were significantly greater than those from animals receiving only tamoxifen. Similarly, maximally amphetamine-stimulated responses were obtained from estradiol + tamoxifen-treated rats, however, in contrast to potassium, these values were significantly greater than both animals receiving either estradiol or tamoxifen alone. These data demonstrate that the nigrostriatal dopaminergic system appears particularly sensitive to the modulatory effects of a combined treatment with estradiol + tamoxifen. Moreover, some of the potential mechanisms of these responses are indicated by the differential dopamine outputs as evoked by potassium or amphetamine. The significance of these synergistic actions is their potential to mimic changes that may occur under conditions of tamoxifen treatment of premenopausal women as has been suggested for women at risk for breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000127236" target="_blank" rel="noreferrer noopener">10.1159/000127236</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
amphetamine
Anderson L I
antiestrogens
brain metastases
breast-cancer
catecholamines
chronic estradiol
Dluzen D E
Endocrinology & Metabolism
female cd-1 mice
Journal Article or Conference Abstract Publication
McDermott J L
Neuroendocrinology
Neurosciences & Neurology
ovarian steroids
progesterone
rat
Receptors
release
sexual-behavior
striatum
uptake sites
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
801-803
Issue
10
Volume
11
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interactive effects of tamoxifen and oestrogen upon the nigrostriatal dopaminergic system: Long-term treatments
Publisher
An entity responsible for making the resource available
Journal of Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-10
Subject
The topic of the resource
receptors; Neurosciences & Neurology; Endocrinology & Metabolism; estrogen; binding; catecholamines; brain; striatum; time; amphetamine; estradiol; antiestrogens; ovarian steroids; sexual-behavior; anti-oestrogens
Creator
An entity primarily responsible for making the resource
McDermott J L; Anderson L I; Dluzen D E
Description
An account of the resource
In the present report adult female rats were ovariectomized (OVX) and assigned to one of four treatment conditions. Treatments consisted of administering pellets containing 17 beta-oestradiol (E), tamoxifen (TMX), a combination of TMX and E or no further treatment (OVX), Animals received these treatments immediately following OVX and were maintained in these conditions for a 40-day period. Subsequently, the corpus striatum (CS) was dissected from each animal and prepared for determinations of basal and amphetamine stimulated DA output using in-vitro superfusion. No statistically significant differences among the four treatment groups were obtained for basal dopamine output. The highest levels of amphetamine-stimulated dopamine responses were obtained from E treated rats. These values were significantly greater than that obtained from OVX rats and rats treated with a combination of TMX + E. The significance of these findings is that they indicate both a non-traditional central nervous system site and mechanism of action through which tamoxifen-oestrogen interactions can function. Such data may have important implications for administration of tamoxifen to premenopausal women as this anti-oestrogen may compromise nigrostriatal dopaminergic function under conditions where oestrogenic modulation is present.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1999
amphetamine
Anderson L I
anti-oestrogens
antiestrogens
Binding
Brain
catecholamines
Dluzen D E
Endocrinology & Metabolism
estradiol
estrogen
Journal Article or Conference Abstract Publication
Journal of neuroendocrinology
McDermott J L
Neurosciences & Neurology
ovarian steroids
Receptors
sexual-behavior
striatum
Time