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<a href="http://doi.org/10.1016/s0142-9612(03)00189-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0142-9612(03)00189-3</a>
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Pages
3493-3503
Issue
20
Volume
24
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Title
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Synthesis, Permeability And Biocompatibility Of Tricomponent Membranes Containing Polyethylene Glycol, Polydimethylsiloxane And Polypentamethylcyclopentasiloxane Domains
Publisher
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Biomaterials
Date
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2003
2003-09
Subject
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biocompatibility; compatibility; delivery; Engineering; hydrogels; insulin diffusion; Materials Science; membrane; molecular weight cut-off; networks; oxygen diffusion; star; surface-properties; water
Creator
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Kurian P; Kasibhatla B; Daum J; Burns C A; Moosa M; Rosenthal K S; Kennedy J P
Description
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The synthesis of "smart" tricomponent amphiphilic membranes containing poly(ethylene glycol) (PEG), polydimethylsiloxane (PDMS) and polypentamethylcyclopentasiloxane (PD(5)) domains is described. Contact angle hysteresis indicates that in air, the surfaces of such PEG/PD(5)/PDMS membranes are enriched by the hydrophobic components, PDMS and PD(5), while in water, the surfaces are rich in the hydrophilic PEG. The oxygen permeability of a series of membranes with varying M(c,hydrophilic) (M(n,PEG) = 4600, 10,000 and 20,000 g/mol) and varying PEG/PD(5)/PDMS compositions was studied. Oxygen permeability increased with the amount of PDMS in the membrane. The molecular weight cut-off (MWCO) ranges and permeability coefficients of insulin through a series of PEG/PD(5)/PDMS(=29/14/57) membranes with varying M(c,hydrophilic) were determined. Insulin permeability is directly related to Mc,hydrophilic of the membrane. MWCO studies show that the membranes are semipermeable to, i.e., allow the transport of smaller proteins such as insulin (M(n) = 5733 g/mol, R(s) = 1.34 nm) and cytochrome c (M(n) = 12,400 g/mol, R(s) = 1.63 nm), but are barriers to larger proteins such as albumin (M(n) = 66,000 g/mol, R(s) = 3.62 nm). Implantation of representative membranes in rats showed them to be biocompatible. According to these studies, PEG/PD(5)/PDMS membranes may be suitable for biological applications, e.g., immunoisolation of cells. (C) 2003 Elsevier Science Ltd. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/s0142-9612(03)00189-3" target="_blank" rel="noreferrer noopener">10.1016/s0142-9612(03)00189-3</a>
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Journal Article or Conference Abstract Publication
2003
Biocompatibility
Biomaterials
Burns C A
compatibility
Daum J
Delivery
Engineering
hydrogels
insulin diffusion
Journal Article or Conference Abstract Publication
Kasibhatla B
Kennedy J P
Kurian P
Materials Science
membrane
molecular weight cut-off
Moosa M
networks
oxygen diffusion
Rosenthal K S
star
surface-properties
Water