Serum procalcitonin in the diagnosis and management of intra-abdominal infections
acute; anti-thymocyte globulin; antibiotic-therapy; antibiotic-therapy; appendicitis; c-reactive protein; critically-ill patients; intensive-care units; international multicenter; liver-transplantation; liver-transplantation; major abdominal-surgery; pancreatitis; peritonitis; Pharmacology & Pharmacy; procalcitonin; sepsis; spontaneous bacterial
The biomarker procalcitonin (PCT) has been used to diagnose and monitor a number of clinically significant infections. Serum levels of PCT are often increased in the presence of bacterial and fungal infections but not viral infections or noninfectious inflammation. Intra-abdominal infections (IAIs) are serious conditions that pose difficult challenges to physicians and the healthcare system. Researchers have evaluated PCT in the management of IAIs, both for diagnosis and for guiding antibiotic therapy. The studies have produced mixed results, leading to controversy on the utility of PCT in IAIs. PCT appears to be most useful in diagnosing postoperative infections and necrotizing pancreatitis. This review aims to summarize these data, explore the pathophysiology of PCT in sepsis from IAIs, discuss the strengths and weaknesses of PCT monitoring in IAIs, and provide guidance for the interpretation of PCT levels.
Watkins R R; Lemonovich T L
Expert Review of Anti-Infective Therapy
2012
2012-02
Journal Article
<a href="http://doi.org/10.1586/eri.11.164" target="_blank" rel="noreferrer noopener">10.1586/eri.11.164</a>
Propofol-Induced Severe Necrotizing Pancreatitis.
propofol; pancreatitis
Propofol is a widely used sedative for gastrointestinal endoscopic procedures. Drug-induced pancreatitis is a relatively rare disease possibly because of poor recognition. Propofol-induced pancreatitis is an extremely rare phenomenon. We present a 22-year-old healthy man who underwent esophagogastroduodenoscopy with propofol as a sedative. Soon after, he developed acute upper gastrointestinal symptoms and was diagnosed with pancreatitis. His prolonged hospital course was complicated with necrotizing pancreatitis, acute respiratory distress syndrome, septic shock, and other end-organ damages. We hope to increase awareness of a life-threatening adverse event of a commonly used anesthetic such as propofol.
Parekh A;Zhang H
ACG Case Reports Journal
2021
2021-01
journalArticle
<a href="http://doi.org/10.14309/crj.0000000000000528" target="_blank" rel="noreferrer noopener">10.14309/crj.0000000000000528</a>
CASE-REPORT - METOLAZONE-ASSOCIATED HYPERCALCEMIA AND ACUTE-PANCREATITIS
calcium; diuretics; General & Internal Medicine; hydrochlorothiazide; hypercalcemia; mechanism; metolazone; pancreatitis; parathyroid-hormone; serum; thiazide
Metolazone-induced acute pancreatitis and hypercalcemia are described in a 58-year-old woman with severe congestive cardiac failure. Her symptoms and laboratory abnormalities rapidly resolved upon discontinuation of metolazone. Both clinical and laboratory findings make other etiologies for the patient's pancreatitis extremely unlikely. The pathophysiology of thiazide-related hypercalcemia and pancreatitis is reviewed. To our knowledge, neither hypercalcemia nor the combination of acute pancreatitis with hypercalcemia has been reported previously in association with metolazone therapy, and the association of pancreatitis and metolazone has been noted previously only once.
Anderson P E; Ellis G G; Austin S M
American Journal of the Medical Sciences
1991
1991-10
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/00000441-199110000-00008" target="_blank" rel="noreferrer noopener">10.1097/00000441-199110000-00008</a>
Acute mesenteric vein thrombosis and pancreatitis
Physiology; Endocrinology & Metabolism; pancreatitis; intestinal ischemia; mesenteric vein thrombosis
This article presents a case of acute mesenteric vein thrombosis with small bowel infarction associated with pancreatitis. Although a rare occurrence, the authors suggest this diagnosis should be considered as a possible complication of pancreatic inflammation.
Cornu-Labat G; Kasirajan A; Simon R; Smith D J; Herman M L; Rubin J R
International Journal of Pancreatology
1997
1997-06
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1007/bf02821611" target="_blank" rel="noreferrer noopener">10.1007/bf02821611</a>