1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2020.00043" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2020.00043</a>
Pages
43
Volume
14
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3389/fncir.2020.00043" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3389/fncir.2020.00043</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
NEOMED Postdoc Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic projections from the pedunculopontine tegmental nucleus contact excitatory and inhibitory neurons in the inferior colliculus
Publisher
An entity responsible for making the resource available
Frontiers in Neural Circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07-16
Subject
The topic of the resource
rat; acetylcholine; auditory; brain-stem; plasticity; cells; modulation; neuromodulation; pathways; midbrain; hearing; arousal; acetylcholine-receptors; auditory input; choline acetyltransferase; gabaergic neurons; viral tracing; volume transmission; viral tracing
Creator
An entity primarily responsible for making the resource
Noftz WA; Beebe NL; Mellott JG; Schofield BR
Description
An account of the resource
The inferior colliculus processes nearly all ascending auditory information. Most collicular cells respond to sound, and for a majority of these cells, the responses can be modulated by acetylcholine (ACh). The cholinergic effects are varied and, for the most part, the underlying mechanisms are unknown. The major source of cholinergic input to the inferior colliculus is the pedunculopontine tegmental nucleus (PPT), part of the pontomesencephalic tegmentum known for projections to the thalamus and roles in arousal and the sleep-wake cycle. Characterization of PPT inputs to the inferior colliculus has been complicated by the mixed neurotransmitter population within the PPT. Using selective viral-tract tracing techniques in a ChAT-Cre Long Evans rat, the present study characterizes the distribution and targets of cholinergic projections from PPT to the inferior colliculus. Following the deposit of viral vector in one PPT, cholinergic axons studded with boutons were present bilaterally in the inferior colliculus, with the greater density of axons and boutons ipsilateral to the injection site. On both sides, cholinergic axons were present throughout the inferior colliculus, distributing boutons to the central nucleus, lateral cortex, and dorsal cortex. In each inferior colliculus (IC) subdivision, the cholinergic PPT axons appear to contact both GABAergic and glutamatergic neurons. These findings suggest cholinergic projections from the PPT have a widespread influence over the IC, likely affecting many aspects of midbrain auditory processing. Moreover, the effects are likely to be mediated by direct cholinergic actions on both excitatory and inhibitory circuits in the inferior colliculus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fncir.2020.00043" target="_blank" rel="noreferrer noopener">10.3389/fncir.2020.00043</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Acetylcholine
acetylcholine-receptors
Arousal
Auditory
auditory input
August 2020 List
Beebe NL
brain-stem
Cells
Choline acetyltransferase
Department of Anatomy & Neurobiology
Frontiers in neural circuits
gabaergic neurons
Hearing
journalArticle
Mellott JG
midbrain
modulation
NEOMED College of Medicine
NEOMED College of Medicine Postdoc
NEOMED Postdoc Publications
neuromodulation
Noftz WA
pathways
plasticity
rat
Schofield BR
viral tracing
volume transmission
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1042/cs20070160" target="_blank" rel="noreferrer noopener">http://doi.org/10.1042/cs20070160</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
357-364
Issue
7
Volume
113
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ace2 Overexpression Inhibits Hypoxia-induced Collagen Production By Cardiac Fibroblasts
Publisher
An entity responsible for making the resource available
Clinical Science
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
angiotensin-converting enzyme 2 (ACE2); angiotensin-converting enzyme-2; collagen; cross-talk; expression; fibroblast; growth-factor-beta; heart failure; hypoxia; Myocardial infarction; myofibroblast differentiation; oxidative stress; pathways; rat; remodelling; Research & Experimental Medicine; signaling; transforming growth factor beta (TGF beta)
Creator
An entity primarily responsible for making the resource
Grobe J L; Der Sarkissian S; Stewart J M; Meszaros J G; Raizada M K; Katovich M J
Description
An account of the resource
Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. Our previous studies have shown an anti-remodelling role of ACE2 (angiotensin-converting enzyme 2) in vivo during hypertension and that these protective effects are mediated through increased circulating levels of Ang-(1-7) [angiotensin-(1-7)]. In the present study, we have demonstrated that cardiac myocytes have modest ACE2 activity, whereas cardiac fibroblasts do not: exhibit any endogenous activity. As fibroblasts are the major cell type found in an infarct zone following a myocardial infarction, we examined the effects of ACE2 gene delivery to cultured cardiac fibroblasts after acute hypoxic exposure. Cardiac fibroblasts from 5-day-old Sprague-Dawley rat hearts were grown to confluence and transduced with a lentiviral vector containing murine ACE2 cDNA under transcriptional control by the EFI alpha (elongation factor I alpha) promoter (lenti-ACE2). Transduction of fibroblasts with lenti-ACE2 resulted in a viral dose-dependent increase in ACE2 activity. This was associated with a significant attenuation of both basal and hypoxia/re-oxygenation-induced collagen production by the fibroblasts. Cytokine production, specifically TGF beta (transforming growth factor beta), by these cells was also significantly attenuated by ACE2 expression. Collectively, these results indicate that: (i) endogenous ACE2 activity is observed in cardiac myocytes, but not in cardiac fibroblasts; (ii) ACE2 overexpression in the cardiac fibroblast attenuates collagen production; and (iii) this prevention is probably mediated by decreased expression of cytokines. We conclude that ACE2 expression, limited to cardiac fibroblasts, may represent a novel paradigm for in vivo therapy following acute ischaemia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1042/cs20070160" target="_blank" rel="noreferrer noopener">10.1042/cs20070160</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
angiotensin-converting enzyme 2 (ACE2)
angiotensin-converting enzyme-2
Clinical Science
Collagen
cross-talk
Der Sarkissian S
expression
fibroblast
Grobe J L
growth-factor-beta
Heart failure
hypoxia
Journal Article or Conference Abstract Publication
Katovich M J
Meszaros J G
myocardial infarction
myofibroblast differentiation
Oxidative Stress
pathways
Raizada M K
rat
remodelling
Research & Experimental Medicine
Signaling
Stewart J M
transforming growth factor beta (TGF beta)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/c0ib00034e" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/c0ib00034e</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
435-442
Issue
9
Volume
2
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta 1 integrins
Publisher
An entity responsible for making the resource available
Integrative Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010
Subject
The topic of the resource
cytoskeleton; mechanotransduction; integrin; Cell Biology; Extracellular matrix; pathways; kinase; shear-stress; focal adhesions; living cells; stretch
Creator
An entity primarily responsible for making the resource
Matthews B D; Thodeti C K; Tytell J D; Mammoto A; Overby D R; Ingber D E
Description
An account of the resource
Integrins are ubiquitous transmembrane mechanoreceptors that elicit changes in intracellular biochemistry in response to mechanical force application, but these alterations generally proceed over seconds to minutes. Stress-sensitive ion channels represent another class of mechanoreceptors that are activated much more rapidly (within msec), and recent findings suggest that calcium influx through Transient Receptor Potential Vanilloid-4 (TRPV4) channels expressed in the plasma membrane of bovine capillary endothelial cells is required for mechanical strain-induced changes in focal adhesion assembly, cell orientation and directional migration. However, whether mechanically stretching a cell's extracellular matrix (ECM) adhesions might directly activate cell surface ion channels remains unknown. Here we show that forces applied to beta 1 integrins result in ultra-rapid (within 4 msec) activation of calcium influx through TRPV4 channels. The TRPV4 channels were specifically activated by mechanical strain in the cytoskeletal backbone of the focal adhesion, and not by deformation of the lipid bilayer or submembranous cortical cytoskeleton alone. This early-immediate calcium signaling response required the distal region of the b1 integrin cytoplasmic tail that contains a binding site for the integrin-associated transmembrane CD98 protein, and external force application to CD98 within focal adhesions activated the same ultra-rapid calcium signaling response. Local direct strain-dependent activation of TRPV4 channels mediated by force transfer from integrins and CD98 may therefore enable compartmentalization of calcium signaling within focal adhesions that is critical for mechanical control of many cell behaviors that underlie cell and tissue development.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/c0ib00034e" target="_blank" rel="noreferrer noopener">10.1039/c0ib00034e</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2010
Cell Biology
cytoskeleton
Extracellular Matrix
Focal Adhesions
Ingber D E
Integrative Biology
integrin
Journal Article or Conference Abstract Publication
Kinase
living cells
Mammoto A
Matthews B D
Mechanotransduction
Overby D R
pathways
shear-stress
stretch
Thodeti C K
Tytell J D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Volume
141
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanisms of bile acid inhibition of bile acid synthesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
liver; pathways; nuclear receptors; negative feedback-regulation; impairs; pruritus; rifampicin
Creator
An entity primarily responsible for making the resource
Chiang J Y L; Li T; Spalding-Yoder B; Del Signore S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book/Monograph
2005
Book/Monograph
Chiang J Y L
Del Signore S
impairs
Li T
Liver
negative feedback-regulation
Nuclear Receptors
pathways
Pruritus
rifampicin
Spalding-Yoder B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(93)90943-h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(93)90943-h</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
99-104
Issue
1
Volume
628
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
VISUAL DEPRIVATION DECREASES LONG-TERM POTENTIATION IN RAT VISUAL CORTICAL SLICES
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-11
Subject
The topic of the resource
cortex; rat; plasticity; depression; period; Neurosciences & Neurology; pathways; induction; long-term potentiation; organization; nmda receptors; evoked-potentials; visual cortex; critical; current source density; dark rearing; monocular deprivation; source density analysis
Creator
An entity primarily responsible for making the resource
Berry R L; Perkins A T; Teyler T J
Description
An account of the resource
A major finding in the visual plasticity literature is that visual deprivation is effective only during an early 'sensitive' period, which is lengthened by dark rearing. Unresolved is whether the visual cortex is in a normally plastic state prior to light stimulation. This cannot be addressed using paradigms employing light exposure to assess plasticity. Several developmental studies have investigated a plastic phenomenon termed long-term potentiation (LTP) in slices from cat (J. Neurophysiol., 59 (1988) 124-141) and rat (Brain Res., 439 (1988) 222-229) visual cortex. Susceptibility to the induction of LTP parallels the period of sensitivity to visual deprivation. This suggests that slices can be used to assay visual cortical plasticity, avoiding light exposure. In the present study, field potentials were recorded from slices of the primary visual cortices of dark-reared (DR) and control (CONT) Long Evans hooded rats (17 to 21 days). Field potential profiles recorded before and 90 min following tetanic electrical stimulation were subjected to current source density analysis, yielding extracellular current sink amplitudes. Tetanus resulted in LTP in both CONT and DR slices, but DR slices were significantly less potentiated. These results indicate that the primary visual cortex of DR animals is not fully plastic, indicating a role for light stimulation in inducing visual cortical plasticity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(93)90943-h" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90943-h</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1993
Berry R L
Brain research
cortex
critical
current source density
dark rearing
Depression
evoked-potentials
induction
Journal Article or Conference Abstract Publication
Long-Term Potentiation
monocular deprivation
Neurosciences & Neurology
nmda receptors
organization
pathways
period
Perkins A T
plasticity
rat
source density analysis
Teyler T J
visual cortex
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
387-407
Issue
3
Volume
404
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Immunohistochemistry and spinal projections of the reticular formation in the northern leopard frog, Rana pipiens
Publisher
An entity responsible for making the resource available
Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-02
Subject
The topic of the resource
american opossum; amphibian; brain-stem; central-nervous-system; descending; enkephalin; intermediolateral cell column; Neurosciences & Neurology; pathways; reticulospinal; serotonin; somatostatin; somatostatin-immunoreactive; stem reticulospinal nuclei; structures; substance P; substance-p-like; tyrosine-hydroxylase; ventral medulla-oblongata; Zoology
Creator
An entity primarily responsible for making the resource
Adli D S H; Stuesse S L; Cruce W L R
Description
An account of the resource
Over 30 nuclei have been identified in the reticular formation of rats, but only a small number of distinct reticular nuclei have been recognized in frogs. We used immunohistochemistry, retrograde tracing, and cell morphology to identify nuclei within the brainstem of Rana pipiens. FluoroGold was injected into the spinal cord, and, in the same frogs, antibodies to enkephalin, substance P, somatostatin, and serotonin were localized in adjacent sections. We identified many previously unrecognized reticular nuclei. The rhombencephalic reticular formation contained reticularis (r.) dorsalis; r. ventralis, pars alpha and pars beta; r. magnocellularis; r. parvocellularis; r. gigantocellularis; r. paragigantocellularis lateralis and dorsalis; r. pontis caudalis, pars alpha and pars beta; nucleus visceralis secundarius; r. pontis oralis, pars medialis and pars lateralis; raphe obscurus; raphe pallidus; raphe magnus; and raphe pontis. The mesencephalic reticular formation contained locus coeruleus-subcoeruleus, r. cuneiformis, r. subcuneiformis, raphe dorsalis-raphe centralis superior, and raphe linearis. Thus, the reticular formation of frog, which is an anamniote, is organized complexly and is similar to the reticular formation in amniotes. Because many of these nuclei may be homologous to reticular nuclei in mammals, we used mammalian terminology for frog reticular nuclei. (C) 1999 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1999
Adli D S H
american opossum
amphibian
brain-stem
central-nervous-system
Cruce W L R
descending
Enkephalin
intermediolateral cell column
Journal Article or Conference Abstract Publication
Journal of Comparative Neurology
Neurosciences & Neurology
pathways
reticulospinal
serotonin
somatostatin
somatostatin-immunoreactive
stem reticulospinal nuclei
structures
Stuesse S L
SUBSTANCE P
substance-p-like
tyrosine-hydroxylase
ventral medulla-oblongata
Zoology