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Text
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URL Address
<a href="http://doi.org/10.1586/eci.12.25" target="_blank" rel="noreferrer noopener">http://doi.org/10.1586/eci.12.25</a>
Rights
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Pages
383-394
Issue
4
Volume
8
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Dublin Core
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Title
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Immune response to CMV in solid organ transplant recipients: current concepts and future directions
Publisher
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Expert Review of Clinical Immunology
Date
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2012
2012-05
Subject
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adaptive immunity; antibody; cd4(+) t-cells; cell-mediated-immunity; CMV; human cytomegalovirus-infection; Immunology; innate immunity; kidney-transplantation; liver-transplantation; long-term; lung transplantation; preemptive therapy; receptor repertoire; recipient; renal-transplant; Toll-like receptor; transplantation; vaccine
Creator
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Watkins R R; Lemonovich T L; Razonable R R
Description
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Despite advances in immunosuppression and antiviral therapy, CMV continues to be a significant opportunistic pathogen adversely affecting the outcome of solid organ transplantation (SOT) recipients. While a significant proportion of CMV disease is caused by reactivation of latent virus, the risk is highest among CMV donor+ and recipient- SOT patients. CMV is responsible for both direct (e.g., pneumonitis, colitis) and indirect (e.g., rejection, atherosclerosis) morbidity and mortality. Healthy CMV-seropositive individuals have a high frequency of CMV-specific CD4(+) and CD8(+) T cells that provide immune protection by limiting CMV reactivation and replication. Changes to the innate and adaptive immune system from immunosuppressive therapy following SOT contribute to CMV disease pathogenesis. CMV disease after SOT is associated with poorer outcomes, thus novel strategies to prevent it are an area of active research. In this article, we review the current state of knowledge on the immune response to CMV following SOT.
Identifier
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<a href="http://doi.org/10.1586/eci.12.25" target="_blank" rel="noreferrer noopener">10.1586/eci.12.25</a>
Format
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Journal Article
2012
Adaptive Immunity
antibody
cd4(+) t-cells
cell-mediated-immunity
CMV
Department of Internal Medicine
Expert Review of Clinical Immunology
human cytomegalovirus-infection
Immunology
Innate immunity
Journal Article
kidney-transplantation
Lemonovich T L
liver-transplantation
long-term
lung transplantation
NEOMED College of Medicine
preemptive therapy
Razonable R R
receptor repertoire
recipient
renal-transplant
Toll-like receptor
Transplantation
Vaccine
Watkins R R