1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/14653249.2012.684380" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/14653249.2012.684380</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
983-993
Issue
8
Volume
14
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiac Pressure Overload Initiates A Systemic Stem Cell Response
Publisher
An entity responsible for making the resource available
Cytotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-09
Subject
The topic of the resource
& Experimental Medicine; acute myocardial-infarction; Biotechnology & Applied Microbiology; bone marrow; bone marrow; cardiac stem cells; cardiomyocytes; Cell Biology; endogenous stem cells; endothelial; endothelial progenitor cells; heart; Hematology; hypertrophy; identification; murine; peripheral-blood; progenitor cells; regeneration; Research; spleen; SSEA-1; transaortic constriction; transplantation
Creator
An entity primarily responsible for making the resource
Finan A; Kiedrowski M; Turturice B A; Sopko N A; Penn M S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/14653249.2012.684380" target="_blank" rel="noreferrer noopener">10.3109/14653249.2012.684380</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
& Experimental Medicine
2012
acute myocardial-infarction
Biotechnology & Applied Microbiology
bone marrow
cardiac stem cells
cardiomyocytes
Cell Biology
Cytotherapy
endogenous stem cells
Endothelial
endothelial progenitor cells
Finan A
heart
Hematology
Hypertrophy
identification
Kiedrowski M
murine
Penn M S
peripheral-blood
progenitor cells
Regeneration
Research
Sopko N A
spleen
SSEA-1
transaortic constriction
Transplantation
Turturice B A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
451-460
Issue
5
Volume
60
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Strategies for cardiovascular repair: role of stem cells in 2012 and beyond
Publisher
An entity responsible for making the resource available
Minerva Cardioangiologica
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-10
Subject
The topic of the resource
acute myocardial-infarction; cardiomyopathy; Cardiovascular diseases; Cardiovascular System & Cardiology; gene-therapy; improves cardiac-function; ischemic; marrow; progenitor cells; regeneration enhancement; Regenerative medicine; stem-cells; topcare-ami; transplantation; trial
Creator
An entity primarily responsible for making the resource
Penn M S; Silver K H
Description
An account of the resource
Stem cell based repair of the heart has captured the mind and imagination of cardiovascular specialists and the lay public. Significant progress has been made at the bench defining the mechanisms of action. This work has gone on further to demonstrate that there is an endogenous stem cell based repair process that attempts to repair the myocardium in response to acute ischemic injury. At the same time investigators at both the bench and in clinical populations have investigated the effects of distinct adult stem cell populations in the peri-infarct period as well as patients with chronic heart failure. In this review we attempt to lay a framework to review how cardiovascular regenerative medicine has progressed to date, summarize what we have learned to date, and discuss how the field may evolve in the future.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
acute myocardial-infarction
Cardiomyopathy
CARDIOVASCULAR diseases
Cardiovascular System & Cardiology
gene-therapy
improves cardiac-function
ischemic
Journal Article
marrow
Minerva Cardioangiologica
Penn M S
progenitor cells
regeneration enhancement
Regenerative Medicine
Silver K H
stem-cells
topcare-ami
Transplantation
trial
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1001/jama.2012.28726" target="_blank" rel="noreferrer noopener">http://doi.org/10.1001/jama.2012.28726</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2380-2389
Issue
22
Volume
308
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of the Use and Timing of Bone Marrow Mononuclear Cell Delivery on Left Ventricular Function After Acute Myocardial Infarction The TIME Randomized Trial
Publisher
An entity responsible for making the resource available
Jama-Journal of the American Medical Association
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-12
Subject
The topic of the resource
cardiosphere-derived cells; double-blind; General & Internal Medicine; intracoronary infusion; ischemic-heart-disease; progenitor cells; reduced neovascularization capacity; regeneration; repair; research network; stem-cells; therapy
Creator
An entity primarily responsible for making the resource
Traverse J H; Henry T D; Pepine C J; Willerson J T; Zhao D X M; Ellis S G; Forder J R; Anderson R D; Hatzopoulos A K; Penn M S; Perin E C; Chambers J; Baran K W; Raveendran G; Lambert C; Lerman A; Simon D I; Vaughan D E; Lai D J; Gee A P; Taylor D A; Cogle C R; Thomas J D; Olson R E; Bowman S; Francescon J; Geither C; Handberg E; Kappenman C; Westbrook L; Piller L B; Simpson L M; Baraniuk S; Loghin C; Aguilar D; Richman S; Zierold C; Spoon D B; Bettencourt J; Sayre S L; Vojvodic R W; Skarlatos S I; Gordon D J; Ebert R F; Kwak M; Moye L A; Simari R D; Cctrn
Description
An account of the resource
Context While the delivery of cell therapy after ST-segment elevation myocardial infarction (STEMI) has been evaluated in previous clinical trials, the influence of the timing of cell delivery on the effect on left ventricular function has not been analyzed. Objectives To determine the effect of intracoronary autologous bone marrow mononuclear cell (BMC) delivery after STEMI on recovery of global and regional left ventricular function and whether timing of BMC delivery (3 days vs 7 days after reperfusion) influences this effect. Design, Setting, and Patients A randomized, 2 x 2 factorial, double-blind, placebo-controlled trial, Timing In Myocardial infarction Evaluation (TIME) enrolled 120 patients with left ventricular dysfunction (left ventricular ejection fraction [LVEF] <= 45%) after successful primary percutaneous coronary intervention (PCI) of anterior STEMI between July 17, 2008, and November 15, 2011, as part of the Cardiovascular Cell Therapy Research Network sponsored by the National Heart, Lung, and Blood Institute. Interventions Intracoronary infusion of 150 x 10(6) BMCs or placebo (randomized 2: 1) within 12 hours of aspiration and cell processing administered at day 3 or day 7 (randomized 1: 1) after treatment with PCI. Main Outcome Measures The primary end points were change in global (LVEF) and regional (wall motion) left ventricular function in infarct and border zones at 6 months measured by cardiac magnetic resonance imaging and change in left ventricular function as affected by timing of treatment on day 3 vs day 7. The secondary end points included major adverse cardiovascular events as well as changes in left ventricular volumes and infarct size. Results The mean (SD) patient age was 56.9 (10.9) years and 87.5% of participants were male. At 6 months, there was no significant increase in LVEF for the BMC group (45.2% [95% CI, 42.8% to 47.6%] to 48.3% [95% CI, 45.3% to 51.3%) vs the placebo group (44.5% [95% CI, 41.0% to 48.0%] to 47.8% [95% CI, 43.4% to 52.2%]) (P=.96). There was no significant treatment effect on regional left ventricular function observed in either infarct or border zones. There were no significant differences in change in global left ventricular function for patients treated at day 3 (-0.9% [95% CI, -6.6% to 4.9%], P=.76) or day 7 (1.1% [95% CI, -4.7% to 6.9%], P=.70). The timing of treatment had no significant effect on regional left ventricular function recovery. Major adverse events were rare among all treatment groups. Conclusion Among patients with STEMI treated with primary PCI, the administration of intracoronary BMCs at either 3 days or 7 days after the event had no significant effect on recovery of global or regional left ventricular function compared with placebo.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/jama.2012.28726" target="_blank" rel="noreferrer noopener">10.1001/jama.2012.28726</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
Aguilar D
Anderson R D
Baran K W
Baraniuk S
Bettencourt J
Bowman S
cardiosphere-derived cells
Cctrn
Chambers J
Cogle C R
double-blind
Ebert R F
Ellis S G
Forder J R
Francescon J
Gee A P
Geither C
General & Internal Medicine
Gordon D J
Handberg E
Hatzopoulos A K
Henry T D
intracoronary infusion
ischemic-heart-disease
Jama-Journal of the American Medical Association
Journal Article
Kappenman C
Kwak M
Lai D J
Lambert C
Lerman A
Loghin C
Moye L A
Olson R E
Penn M S
Pepine C J
Perin E C
Piller L B
progenitor cells
Raveendran G
reduced neovascularization capacity
Regeneration
repair
research network
Richman S
Sayre S L
Simari R D
Simon D I
Simpson L M
Skarlatos S I
Spoon D B
stem-cells
Taylor D A
therapy
Thomas J D
Traverse J H
Vaughan D E
Vojvodic R W
Westbrook L
Willerson J T
Zhao D X M
Zierold C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2217/rme.13.38" target="_blank" rel="noreferrer noopener">http://doi.org/10.2217/rme.13.38</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
381-384
Issue
4
Volume
8
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Dublin Core
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Title
A name given to the resource
The importance of understanding the molecular mechanism of stem cell-induced cardiac tissue repair
Publisher
An entity responsible for making the resource available
Regenerative Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-07
Subject
The topic of the resource
acute myocardial-infarction; acute myocardial-infarction; Cell Biology; chemokines; chronic heart-failure; chronic heart-failure; delivery; endogenous stem cell repair; Engineering; factor-i; ischemic cardiomyopathy; left-ventricular function; marrow; mononuclear-cells; progenitor cells; randomized-trial; sdf-1cxcr4 axis; stem-cells
Creator
An entity primarily responsible for making the resource
Penn M S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2217/rme.13.38" target="_blank" rel="noreferrer noopener">10.2217/rme.13.38</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2013
acute myocardial-infarction
Cell Biology
chemokines
chronic heart-failure
Delivery
endogenous stem cell repair
Engineering
factor-i
ischemic cardiomyopathy
Journal Article
left-ventricular function
marrow
mononuclear-cells
Penn M S
progenitor cells
randomized-trial
Regenerative Medicine
sdf-1cxcr4 axis
stem-cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/circresaha.111.253427" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/circresaha.111.253427</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
304-+
Issue
2
Volume
110
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adventitial Delivery of an Allogeneic Bone Marrow-Derived Adherent Stem Cell in Acute Myocardial Infarction Phase I Clinical Study
Publisher
An entity responsible for making the resource available
Circulation Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
adventitia; Cardiovascular System & Cardiology; clinical-trial; double-blind; Heart failure; Hematology; myocardial infarction; progenitor cells; regeneration; stem-cells; transplantation
Creator
An entity primarily responsible for making the resource
Penn M S; Ellis S; Gandhi S; Greenbaum A; Hodes Z; Mendelsohn F O; Strasser D; Ting A E; Sherman W
Description
An account of the resource
Rationale: MultiStem is an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in preclinical models of acute myocardial infarction (AMI). In this phase I clinical trial in patients with first ST-elevation-myocardial infarction (STEMI), we combine first-in-man delivery of MultiStem with a first-in-coronary adventitial delivery system to determine the effects of this system on left ventricular function at 4 months after AMI. Objective: Test the effects of adventitial delivery of Multistem in the peri-infarct period in patients with first STEMI. Methods and Results: This study was a phase I, open-label, dose-escalating registry control group study. Nineteen patients received MultiStem (20 million, n=6; 50 million, n=7; or 100 million, n=6) and 6 subjects were assigned to the registry control group. Two to 5 days after AMI, we delivered MultiStem to the adventitia of the infarct-related vessel in patients with first-time STEMI. All patients underwent primary percutaneous coronary intervention with resulting Thrombolysis In Myocardial Infarction grade 3 flow and with ejection fraction (EF) <= 45% as determined by echocardiogram or left ventriculogram within 12 hours of primary percutaneous coronary intervention. The cell product (20 million, 50 million, or 100 million) was well tolerated, and no serious adverse events were deemed related to MultiStem. There was no increase in creatine kinase-MB or troponin associated with the adventitial delivery of MultiStem. In patients with EF determined to be <= 45% by a core laboratory within 24 hours before the MultiStem injection, we observed a 0.9 (n=4), 3.9 (n=4), 13.5 (n=5), and 10.9 (n=2) percent absolute increases in EF in the registry, 20 million, 50 million, and 100 million dose groups, respectively. The increases in EF in the 50 million and 100 million groups were accompanied by 25.4 and 8.4 mL increases in left ventricular stroke volume. Conclusions: In this study, the delivery of MultiStem to the myocardium in patients with recent STEMI was well tolerated and safe. In patients who exhibited significant myocardial damage, the delivery of >= 50 million MultiStem resulted in improved EF and stroke volume 4 months later. These findings support further development of MultiStem in patients with AMI and they validate the potential of a system for delivery of adult stem cells at any time after primary percutaneous coronary intervention. (Circ Res. 2012;110:304-311.)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/circresaha.111.253427" target="_blank" rel="noreferrer noopener">10.1161/circresaha.111.253427</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
adventitia
Cardiovascular System & Cardiology
Circulation research
clinical-trial
double-blind
Ellis S
Gandhi S
Greenbaum A
Heart failure
Hematology
Hodes Z
Journal Article
Mendelsohn F O
myocardial infarction
Penn M S
progenitor cells
Regeneration
Sherman W
stem-cells
Strasser D
Ting A E
Transplantation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pharmthera.2019.03.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pharmthera.2019.03.001</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alcohol abuse and disorder of granulopoiesis.
Publisher
An entity responsible for making the resource available
Pharmacology & therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
*stem cells; Alcohol abuse; Bacterial infection; Bone marrow; Cell signaling; Granulopoiesis; Immune defense; Leukopenia; Progenitor cells; The granulopoietic response
Creator
An entity primarily responsible for making the resource
Shi Xin; DeLucia Angelo L; Bao Jianxin; Zhang Ping
Description
An account of the resource
Granulocytes are the major type of phagocytes constituting the front line of innate immune defense against bacterial infection. In adults, granulocytes are derived from hematopoietic stem cells in the bone marrow. Alcohol is the most frequently abused substance in human society. Excessive alcohol consumption injures hematopoietic tissue, impairing bone marrow production of granulocytes through disrupting homeostasis of granulopoiesis and the granulopoietic response. Because of the compromised immune defense function, alcohol abusers are susceptible to infectious diseases, particularly septic infection. Alcoholic patients with septic infection and granulocytopenia have an exceedingly high mortality rate. Treatment of serious infection in alcoholic patients with bone marrow inhibition continues to be a major challenge. Excessive alcohol consumption also causes diseases in other organ systems, particularly severe alcoholic hepatitis which is life threatening. Corticosteroids are the only therapeutic option for improving short-term survival in patients with severe alcoholic hepatitis. The existence of advanced alcoholic liver diseases and administration of corticosteroids make it more difficult to treat serious infection in alcoholic patients with the disorder of granulopoieis. This article reviews the recent development in understanding alcohol-induced disruption of marrow granulopoiesis and the granulopoietic response with the focus on progress in delineating cell signaling mechanisms underlying the alcohol-induced injury to hematopoietic tissue. Efforts in exploring effective therapy to improve patient care in this field will also be discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pharmthera.2019.03.001" target="_blank" rel="noreferrer noopener">10.1016/j.pharmthera.2019.03.001</a>
*Stem cells
2019
Alcohol abuse
bacterial infection
Bao Jianxin
bone marrow
cell signaling
DeLucia Angelo L
Department of Integrative Medical Sciences
Granulopoiesis
Immune defense
Leukopenia
NEOMED College of Medicine
Pharmacology & therapeutics
progenitor cells
Shi Xin
the granulopoietic response
Zhang Ping