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Text
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URL Address
<a href="http://doi.org/10.1016/j.jmbbm.2013.01.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jmbbm.2013.01.025</a>
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Pages
47-56
Volume
21
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Title
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New Biomaterial As A Promising Alternative To Silicone Breast Implants
Publisher
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Journal of the Mechanical Behavior of Biomedical Materials
Date
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2013
2013-05
Subject
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arborescent; biocompatibility; Biopolymers; block-copolymers; Breast implants; elastomers; Engineering; Histological study; in-vivo; Materials Science; mechanical-properties; polyisobutylene-based biomaterials; polystyrene; prostheses; rupture; SIBS; thermoplastic; women
Creator
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Lim G T; Valente S A; Hart-Spicer C R; Evancho-Chapman M M; Puskas J E; Horne W I; Schmidt S P
Description
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One in eight American women develops breast cancer. Of the many patients requiring mastectomy yearly as a consequence, most elect some form of breast reconstruction. Since 2006, only silicone breast implants have been approved by the FDA for the public use. Unfortunately, over one-third of women with these implants experience complications as a result of tissue-material biocompatibility issues, which may include capsular contracture, calcification, hematoma, necrosis and implant rupture. Our group has been working on developing alternatives to silicone. Linear triblock poly(styrene-b-isobutylene-b-styrene) (SIBS) polymers are self-assembling nanostructured thermoplastic rubbers, already in clinical practice as drug eluting stent coatings. New generations with a branched (arborescent or dendritic) polyisobutylene core show promising potential as a biomaterial alternative to silicone rubber. The purpose of this pre-clinical research was to evaluate the material-tissue interactions of a new arborescent block copolymer (TPE1) in a rabbit implantation model compared to a linear SIBS (SIBSTAR 103T) and silicone rubber. This study is the first to compare the molecular weight and molecular weight distribution, tensile properties and histological evaluation of arborescent SIBS-type materials with silicone rubber before implantation and after explantation. (C) 2013 Elsevier Ltd. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.jmbbm.2013.01.025" target="_blank" rel="noreferrer noopener">10.1016/j.jmbbm.2013.01.025</a>
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Journal Article or Conference Abstract Publication
2013
arborescent
Biocompatibility
Biopolymers
block-copolymers
Breast implants
Department of Pharmaceutical Sciences
elastomers
Engineering
Evancho-Chapman M M
Hart-Spicer C R
Histological study
Horne W I
in-vivo
Journal Article or Conference Abstract Publication
Journal of the Mechanical Behavior of Biomedical Materials
Lim G T
Materials Science
mechanical-properties
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
polyisobutylene-based biomaterials
polystyrene
prostheses
Puskas J E
Rupture
Schmidt S P
SIBS
thermoplastic
Valente S A
Women