1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1152/jappl.2001.90.4.1489" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.2001.90.4.1489</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 1489-1496 Issue 4 Volume 90 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats Publisher An entity responsible for making the resource available Journal of Applied Physiology Date A point or period of time associated with an event in the lifecycle of the resource 2001 2001-04 Subject The topic of the resource anesthetized sheep; cation channels; channels; conductance; cyclic nucleotide-gated cation channels; dibutyryl-guanosine-3'5'-cyclic monophosphate; distal lung; epithelial na+ channel; epithelial sodium ion; guinea-pigs; isoproterenol; l-cis-diltiazem; lung liquid clearance; Physiology; protein clearance; sodium transport; Sport Sciences; terbutaline Creator An entity primarily responsible for making the resource Norlin A; Lu L N; Guggino S E; Matthay M A; Folkesson H G Description An account of the resource The contributions of amiloride-sensitive and -insensitive fractions of alveolar fluid clearance in adult ventilated rats were studied under control conditions and after beta -adrenergic stimulation. Rats were instilled with a 5% albumin solution containing terbutaline (10(-4) M) or dibutyryl-cGMP (DBcGMP; 10-4 M) with or without the cyclic nucleotide-gated cation channel inhibitor l-cis-diltiazem (10(-3) M) and/or amiloride (10-3 M). Alveolar fluid clearance over 1 h was 18 +/- 2% in controls. In controls, amiloride inhibited 46 +/- 15% of alveolar fluid clearance, whereas l-cis-diltiazem had no inhibitory effect. Terbutaline and DBcGMP stimulated alveolar fluid clearance by 85 +/- 3 and 36 +/- 5%, respectively. Amiloride and l-cis-diltiazem inhibited nearly equal fractions of terbutaline-stimulated alveolar fluid clearance when given alone. Amiloride and l-cis-diltiazem given together inhibited a significantly larger fraction of alveolar fluid clearance in terbutaline-stimulated rats and in DBcGMP-stimulated rats. Based on these data, tertbutaline stimulation recruited both amiloride-sensitive and E-cis-diltiazem-sensitive pathways. In contrast, DBcGMP mainly recruited l-cis-diltiazem-sensitive pathways. Therefore, the amiloride-insensitive fraction of Nat-driven alveolar fluid clearance may be partly mediated through cyclic nucleotide-gated cation channels and activated by an increase in intracellular cGMP. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1152/jappl.2001.90.4.1489" target="_blank" rel="noreferrer noopener">10.1152/jappl.2001.90.4.1489</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2001 anesthetized sheep cation channels channels conductance cyclic nucleotide-gated cation channels dibutyryl-guanosine-3'5'-cyclic monophosphate distal lung epithelial na+ channel epithelial sodium ion Folkesson H G Guggino S E guinea-pigs isoproterenol Journal Article Journal of Applied Physiology l-cis-diltiazem Lu L N lung liquid clearance Matthay M A Norlin A Physiology protein clearance sodium transport Sport Sciences terbutaline Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1152/ajplung.00417.2000" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00417.2000</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages L642-L649 Issue 4 Volume 282 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Alveolar epithelial ion and fluid transport - Ca2(+)-dependent stimulation of alveolar fluid clearance in near-term fetal guinea pigs Publisher An entity responsible for making the resource available American Journal of Physiology-Lung Cellular and Molecular Physiology Date A point or period of time associated with an event in the lifecycle of the resource 2002 2002-04 Subject The topic of the resource adrenaline; agonist; amiloride; birth; blood-flow; cation; channel; distal lung epithelium; expression; lamb; liquid; oxytocin-induced preterm labor; Physiology; protein clearance; Respiratory System; sodium transport; surfactant secretion Creator An entity primarily responsible for making the resource Norlin A; Folkesson H G Description An account of the resource We investigated the importance of changes in intracellular Ca2+ concentration ([Ca2+](i)) for amiloride-sensitive alveolar fluid clearance (AFC) in late-gestational guinea pigs. Fetal guinea pigs of 61, 68, and 69 days (term) gestation were investigated under normal conditions and after oxytocin-induced preterm labor. AFC or alveolar fluid secretion was measured using an impermeable tracer technique. At 61 days gestation there was net secretion of fluid into the lungs, and at birth the lungs cleared 49 +/- 7% of the instilled fluid volume over 1 h. Induction of preterm labor with oxytocin induced AFC at 61 days gestation. When present, AFC was inhibited or reversed to net fluid secretion by amiloride (10(-3) M). Inhibition of membrane Ca2+ channels by verapamil (10(-4) M) or depletion of intracellular Ca2+ by thapsigargin (10(-5) M) reduced AFC when net AFC was evident. Amiloride lacked an inhibitory effect on AFC when instilled with verapamil or thapsigargin. The results indicate that AFC via amiloride-sensitive pathways develops during late gestation, and that inducing preterm labor precociously may activate such pathways. Our results suggest that Ca2+ may act as a second messenger in mediating catecholamine-stimulated AFC. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1152/ajplung.00417.2000" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00417.2000</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2002 adrenaline agonist American Journal of Physiology-Lung Cellular and Molecular Physiology amiloride birth blood-flow cation channel distal lung epithelium expression Folkesson H G Journal Article lamb Liquid Norlin A oxytocin-induced preterm labor Physiology protein clearance Respiratory System sodium transport surfactant secretion