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Text
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URL Address
<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.heares.2013.10.003</a>
Pages
131–144
Volume
306
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-12
Subject
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AC; Animals; auditory cortex; Auditory Cortex/*physiology; Auditory Pathways/cytology; Axons/metabolism/*pathology; Brain Mapping; cortical layers; Fast Blue; FB; FD; Female; FG; Fluor0Ruby; fluorescein dextran; Fluorescence; FluoroGold; FR; G-; G+; GAD; GAD-immunonegative; GAD-immunopositive; GAD-neg; gamma-Aminobutyric Acid/metabolism; GB; Glutamate Decarboxylase/metabolism; glutamic acid decarboxylase; green RetroBeads; Guinea Pigs; I-VI; IC; IC central nucleus; IC dorsal cortex; IC lateral cortex; IC rostral cortex; ICc; ICd; IClc; ICrc; Inferior Colliculi/pathology/*physiology; inferior colliculus; Male; Mesencephalon/pathology; Microscopy; ps; pseudosylvian sulcus; rhinal sulcus; rs; white matter; wm
Creator
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Nakamoto Kyle T; Sowick Colleen S; Schofield Brett R
Description
An account of the resource
Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry underlying effects in the contralateral IC is less clear. The direct projection from the AC to the contralateral IC is relatively small. An unexplored possibility is that the large ipsilateral cortical projection contacts the substantial number of cells in the ipsilateral IC that project through the commissure to the contralateral IC. Apparent contacts between cortical boutons and commissural cells were identified in the left IC after injection of different fluorescent tracers into the left AC and the right IC. Commissural cells were labeled throughout the left IC, and many (23-34%) appeared to be contacted by cortical axons. In the central nucleus, both disc-shaped and stellate cells were contacted. Antibodies to glutamic acid decarboxylase (GAD) were used to identify GABAergic commissural cells. The majority (\textgreater86%) of labeled commissural cells were GAD-immunonegative. Despite low numbers of GAD-immunopositive commissural cells, some of these cells were contacted by cortical boutons. Nonetheless, most cortically contacted commissural cells were GAD-immunonegative (i.e., presumably glutamatergic). We conclude that auditory cortical axons contact primarily excitatory commissural cells in the ipsilateral IC that project to the contralateral IC. These corticocollicular contacts occur in each subdivision of the ipsilateral IC, suggesting involvement of commissural cells throughout the IC. This pathway - from AC to commissural cells in the ipsilateral IC - is a prime candidate for the excitatory effects of activation of the auditory cortex on responses in the contralateral IC. Overall this suggests that the auditory corticofugal pathway is integrated with midbrain commissural connections.
Identifier
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<a href="http://doi.org/10.1016/j.heares.2013.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.heares.2013.10.003</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
AC
Animals
auditory cortex
Auditory Cortex/*physiology
Auditory Pathways/cytology
Axons/metabolism/*pathology
Brain Mapping
cortical layers
Department of Anatomy & Neurobiology
Fast Blue
FB
FD
Female
FG
Fluor0Ruby
fluorescein dextran
Fluorescence
FluoroGold
FR
G-
G+
GAD
GAD-immunonegative
GAD-immunopositive
GAD-neg
gamma-Aminobutyric Acid/metabolism
GB
Glutamate Decarboxylase/metabolism
glutamic acid decarboxylase
green RetroBeads
Guinea Pigs
Hearing research
I-VI
IC
IC central nucleus
IC dorsal cortex
IC lateral cortex
IC rostral cortex
ICc
ICd
IClc
ICrc
Inferior Colliculi/pathology/*physiology
inferior colliculus
Male
Mesencephalon/pathology
Microscopy
Nakamoto Kyle T
NEOMED College of Medicine
ps
pseudosylvian sulcus
rhinal sulcus
rs
Schofield Brett R
Sowick Colleen S
white matter
wm