PULMONARY BLASTOMA IN CHILDREN - REPORT OF 2 CASES AND REVIEW OF THE LITERATURE
childhood; lung; pediatric; Pediatrics; pulmonary blastoma; Surgery
Pulmonary blastoma is a rare primary neoplasm of the lung. Approximately 25% of the reported, cases have occurred in pediatric patients. The authors found 45 cases of these tumors in children aged less than or equal to 16 years, and report two more cases of pulmonary blastoma - in a 3 1/2-year-old boy and a 22-month-old girl. Because these tumors are considered malignant, surgical excision is recommended.
Seballos R M; Klein R L
Journal of Pediatric Surgery
1994
1994-12
Journal Article
<a href="http://doi.org/10.1016/0022-3468(94)90214-3" target="_blank" rel="noreferrer noopener">10.1016/0022-3468(94)90214-3</a>
Trisomy 8 is a characteristic finding in pleuropulmonary blastoma
aberrations; childhood; chromosomal-abnormalities; mosaicism; Pathology; Pediatrics; pleuropulmonary blastoma; pulmonary blastoma; trisomy 8; tumors
The cytogenetic findings in pleuropulmonary blastoma (PPB) have not been widely studied and reported and are of interest in view of the implications that PPB has for additional tumors in the patient and the patient's relatives. Using standard tumor cytogenetic methodology, we investigated three cases of PPB encountered in our institution over a 5-year period. Trisomy 8 was the only karyotypic abnormality in a localized type 2 PPB and was present with other abnormalities in another type 2 PPB and a massive type 3 PPB. Review of the literature yielded three additional karyotyped PPBs; all had trisomy 8 as part of the abnormalities detected. Trisomy 8 appears to be a characteristic of PPB and may be related to the development of PPB and related tumors.
Novak R; Dasu S; Agamanolis D; Herold W; Malone J; Waterson J
Pediatric Pathology & Laboratory Medicine
1997
1997-01
Journal Article
<a href="http://doi.org/10.1080/107710497175056" target="_blank" rel="noreferrer noopener">10.1080/107710497175056</a>