1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90576-f</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 229-232 Issue 2 Volume 133 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource EVALUATION OF THE INTERACTIONS OF SEROTONERGIC AND ADRENERGIC-DRUGS WITH MU, DELTA, AND KAPPA OPIOID BINDING-SITES Publisher An entity responsible for making the resource available Neuroscience Letters Date A point or period of time associated with an event in the lifecycle of the resource 1991 1991-12 Subject The topic of the resource receptor; Neurosciences & Neurology; involvement; rat-brain; morphine; dorsal horn; adrenergic; cord; mu opioid; nociceptive; periaqueductal gray; phentolamine; raphe magnus stimulation; reflexes; serotonergic; spinal antinociceptive action; spiroxatrine; delta opioid; kappa opioid Creator An entity primarily responsible for making the resource Monroe P J; Perschke S E; Crisp T; Smith D J Description An account of the resource Several serotonergic and adrenergic agents were tested for an ability to interact with mu, delta, and kappa opioid binding sites. Spiroxatrine interacted nearly equipotently with all three opioid subtypes, yielding K(i) values near 110 nM. A number of other serotonergic and adrenergic agents interacted with affinities in the 1-50-mu-M range. Most of the other compounds tested in this study were found to compete for opioid binding to some degree, though not achieving a 50% inhibition of binding at concentrations up to 100-mu-M. If this interaction between monoaminergic agents and opioid receptors is found to have functional significance, it must be considered in the interpretation of results from studies using these agents to evaluate the contribution of monoaminergic systems to opioid-mediated events. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90576-f</a> Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 1991 Adrenergic cord Crisp T delta opioid dorsal horn involvement Journal Article or Conference Abstract Publication kappa opioid Monroe P J MORPHINE mu opioid Neuroscience letters Neurosciences & Neurology nociceptive periaqueductal gray Perschke S E phentolamine raphe magnus stimulation rat-brain Receptor reflexes serotonergic Smith D J spinal antinociceptive action spiroxatrine