1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1039/c1md00176k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1039/c1md00176k</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1099-1103
Issue
11
Volume
2
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Identification Of Multifunctional Small Molecule-based Reversible Monoamine Oxidase Inhibitors
Publisher
An entity responsible for making the resource available
Medchemcomm
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
analogs; Biochemistry & Molecular Biology; crystal-structures; drugs; mechanism; neuroprotection; parkinsons-disease; Pharmacology & Pharmacy; rasagiline; targets
Creator
An entity primarily responsible for making the resource
Geldenhuys W J; Ko K S; Stinnett H; Van der Schyf C J; Lim M H
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1039/c1md00176k" target="_blank" rel="noreferrer noopener">10.1039/c1md00176k</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
analogs
Biochemistry & Molecular Biology
crystal-structures
Drugs
Geldenhuys W J
Ko K S
Lim M H
mechanism
Medchemcomm
Neuroprotection
parkinsons-disease
Pharmacology & Pharmacy
rasagiline
Stinnett H
Targets
Van der Schyf C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1353-8020(08)70017-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1353-8020(08)70017-8</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S281-S291
Volume
13
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?
Publisher
An entity responsible for making the resource available
Parkinsonism & Related Disorders
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007
Subject
The topic of the resource
A(2A) receptor antagonists; adenosine; alzheimers-disease; amyloid precursor protein; antagonist; bcl-2 family-members; designed multiple ligands; double-blind; dual mechanism; iron chelation; ladostigil; M30; mao-b; monoamine-oxidase-b; neurodegenerative diseases; Neurosciences & Neurology; nmda receptor; rasagiline; tea polyphenol (-)-epigallocatechin-3-gallate
Creator
An entity primarily responsible for making the resource
Youdim M B H; Geldenhuys W J; Van der Schyf C J
Description
An account of the resource
Parkinson's disease (PD) is a severe neurodegenerative disorder, with no available drugs able to prevent the neuronal cell loss characteristic in brains of patients suffering from PD. Due to the complex cascade of molecular events involved in the etiology of PD, an innovative approach towards neuroprotection or neurorescue may entail the use of multifunctional pharmaceuticals that target an array of pathological pathways, each of which is believed to contribute to events that ultimately lead to neuronal cell death. Here we discuss examples of novel multifunctional ligands that may have potential as neuroprotective and neurorestorative therapeutics in PD. The compounds discussed originate from synthetic chemistry as well as from natural sources where various moieties, identified in research to possess neuroprotective and neurorestorative properties, have been introduced into the structures of several monomodal drugs, some of which are used in the clinic. (C) 2007 Elsevier B.V. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s1353-8020(08)70017-8" target="_blank" rel="noreferrer noopener">10.1016/s1353-8020(08)70017-8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2007
A(2A) receptor antagonists
adenosine
alzheimers-disease
amyloid precursor protein
Antagonist
bcl-2 family-members
designed multiple ligands
double-blind
dual mechanism
Geldenhuys W J
iron chelation
Journal Article
ladostigil
M30
mao-b
monoamine-oxidase-b
Neurodegenerative Diseases
Neurosciences & Neurology
nmda receptor
Parkinsonism & Related Disorders
rasagiline
tea polyphenol (-)-epigallocatechin-3-gallate
Van der Schyf C J
Youdim M B H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/nrd2330" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/nrd2330</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4-4
Issue
6
Volume
6
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease?
Publisher
An entity responsible for making the resource available
Nature Reviews Drug Discovery
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-06
Subject
The topic of the resource
Biotechnology & Applied Microbiology; disorders; iron; monoamine-oxidase inhibition; neurodegenerative diseases; neurorescue; Pharmacology & Pharmacy; rasagiline
Creator
An entity primarily responsible for making the resource
Youdim M B H; Van der Schyf C J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nrd2330" target="_blank" rel="noreferrer noopener">10.1038/nrd2330</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2007
Biotechnology & Applied Microbiology
disorders
iron
Journal Article
monoamine-oxidase inhibition
Nature Reviews Drug Discovery
Neurodegenerative Diseases
neurorescue
Pharmacology & Pharmacy
rasagiline
Van der Schyf C J
Youdim M B H