1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.psyneuen.2010.12.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.psyneuen.2010.12.007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
955-969
Issue
7
Volume
36
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways
Publisher
An entity responsible for making the resource available
Psychoneuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
dopamine; mice; Psychiatry; Akt; 3; 2; 1-methyl-4-phenyl-1; Neurosciences & Neurology; Endocrinology & Metabolism; cell-death; activation; neurotoxicity; induced; rat striatum; kinase; striatum; Methamphetamine; evoked striatal dopamine; neurotoxicity; cd-1; element-binding protein; Sex difference; transporter function; 6-tetrahydropyridine mice
Creator
An entity primarily responsible for making the resource
Bourque M; Liu B; Dluzen D E; Di Paolo T
Description
An account of the resource
Mate mice were reported to display greater methamphetamine-induced neurotoxicity than females. The present study evaluated the involvement of phosphatidylinositol-3 kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK1/2) pathways in this sex-dependent methamphetamine toxicity. Intact female and male mice were administered methamphetamine (20 or 40 mg/kg) and euthanized a week later. Dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) autoradiography in the lateral striatum showed a greater sensitivity in male mice treated with 20 mg/kg methamphetamine compared to female mice. Striatal dopamine concentration and DAT autoradiography showed a more extensive depletion in male mice given 40 mg/kg methamphetamine compared to female mice. Mice administered 40 mg/kg methamphetamine showed no sex difference in striatal VMAT2 autoradiography. In the substantia nigra, DAT specific binding was decreased only in male mice treated with 40 mg/kg methamphetamine and DAT mRNA levels decreased in methamphetamine-treated female and male mice. Methamphetamine-treated male mice presented a dose-dependent decrease of VMAT2 mRNA levels. Methamphetamine reduced insulin-like growth factor 1 receptor levels in females at both methamphetamine doses tested whereas it elevated G protein-coupled estrogen receptor 1 (GPER1) only in male mice. Phosphorylated Akt levels decreased only in male mice treated with 40 mg/kg methamphetamine. Glycogen synthase kinase 30 levels were reduced in male mice at both methamphetamine doses tested and in females receiving 40 mg/kg. Bcl-2 Levels were increased in male mice treated with methamphetamine, whereas ERK1/2 and BAD levels were unchanged. These results implicate some of the signaling pathways associated with the sex differences in methamphetamine-induced toxicity. (C) 2011 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.psyneuen.2010.12.007" target="_blank" rel="noreferrer noopener">10.1016/j.psyneuen.2010.12.007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
2
2011
3
6-tetrahydropyridine mice
activation
Akt
Bourque M
cd-1
cell-death
Di Paolo T
Dluzen D E
Dopamine
element-binding protein
Endocrinology & Metabolism
evoked striatal dopamine
Induced
Journal Article or Conference Abstract Publication
Kinase
Liu B
Methamphetamine
Mice
Neurosciences & Neurology
Neurotoxicity
Psychiatry
Psychoneuroendocrinology
rat striatum
Sex difference
striatum
transporter function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)90021-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)90021-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
163-168
Issue
1
Volume
536
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Invivo Changes In Responsiveness Of The Caudate-nucleus To L-dopa Infusion As A Function Of The Estrous-cycle
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
behaviors; caudate nucleus; corpus striatum; dopamine; estrous-cycle; female rats; hormone; in-vitro; l-dihydroxyphenylalanine; Neurosciences & Neurology; progesterone; prolactin; push-pull perfusion; rat striatum; release; sex-differences
Creator
An entity primarily responsible for making the resource
Dluzen D E; Ramirez V D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)90021-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)90021-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
behaviors
Brain research
caudate nucleus
corpus striatum
Dluzen D E
Dopamine
estrous-cycle
female rats
hormone
in-vitro
l-dihydroxyphenylalanine
Neurosciences & Neurology
progesterone
prolactin
push-pull perfusion
Ramirez V D
rat striatum
release
sex-differences