1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jsbmb.2006.02.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jsbmb.2006.02.005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
42-51
Issue
1
Volume
100
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen-mediated regulation of CYP7B1: A possible role for controlling DHEA levels in human tissues
Publisher
An entity responsible for making the resource available
Journal of Steroid Biochemistry and Molecular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-07
Subject
The topic of the resource
7-alpha-hydroxylase; alzheimers-disease; bile-acid biosynthesis; Biochemistry & Molecular Biology; CYP7B1; dehydroepiandrosterone 7-hydroxylase; DHEA; Endocrinology & Metabolism; estrogen; fetal development; gene-expression; human oxysterol 7-alpha-hydroxylase; prostate; rat; receptor-beta; sex hormone biosynthesis; transcriptional regulation; vascular dementia
Creator
An entity primarily responsible for making the resource
Tang W J; Eggertsen G; Chiang J Y L; Norlin M
Description
An account of the resource
The current study examines regulation of CYP7B1, a DHEA 7 alpha-hydroxylase, by sex hormones. Transfection with estrogen receptor alpha and treatment with 17 P-estradiol in human embryonic kidney 293 cells significantly increased CYP7B1 catalytic activity and mRNA, and stimulated a human CYP7B1 reporter gene. Transfection with estrogen receptor P showed similar but less significant effects. In the absence of receptors, 17 P-estradiol suppressed CYP7B1 activity, suggesting that estrogenic effects may be different in cells not expressing receptors. Quantitation of CYP7B1 mRNA in adult and fetal human tissues showed markedly higher CYP7B1 mRNA levels in fetal tissues compared with the corresponding adult ones, except in the liver. This indicates a tissue-specific, developmental regulation of CYP7B1 and suggests an important function for this enzyme in fetal life. DHEA secreted by fetal adrenals is an essential precursor for placental estrogen formation. Since CYP7B1 diverts DHEA from the sex hormone biosynthetic pathway, estrogen receptor-mediated up-regulatio of CYP7B1 should lead to less DHEA available for sex hormone synthesis and may help to maintain normal levels of estrogens and androgens in human tissues, especially during fetal development. Regulation by estrogens may also be of importance in other processes where CYP7B1 is involved, including cholesterol homeostasis, cellular proliferation, and CNS function. (c) 2006 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jsbmb.2006.02.005" target="_blank" rel="noreferrer noopener">10.1016/j.jsbmb.2006.02.005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
7-alpha-hydroxylase
alzheimers-disease
bile-acid biosynthesis
Biochemistry & Molecular Biology
Chiang J Y L
CYP7B1
dehydroepiandrosterone 7-hydroxylase
DHEA
Eggertsen G
Endocrinology & Metabolism
estrogen
fetal development
gene-expression
human oxysterol 7-alpha-hydroxylase
Journal Article
Journal of Steroid Biochemistry and Molecular Biology
Norlin M
Prostate
rat
receptor-beta
sex hormone biosynthesis
Tang W J
transcriptional regulation
vascular dementia