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Molecular mechanisms of nuclear receptor regulation of bile acid synthesis

Tags: 2003, 7-alpha-hydroxylase gene cyp7a1, Book/Monograph, Chen W, Chiang J Y L, cholesterol 7-alpha-hydroxylase, factor 4-alpha, feedback-regulation, heterodimer partner, identification, Norlin M, Owsley E, repression, SHP, transactivation, Transcription, Zhang M

On the mechanism of bile acid inhibition of rat sterol 12 alpha-hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4 alpha

The sterol 12alpha-hydroxylase (CYP8B1) is a key enzyme of the bile acid biosynthetic pathway. It regulates the composition of bile acids in bile, i.e. ratio between cholic acid (CA) and chenodeoxycholic acid (CDCA). In similarity with cholesterol…

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