1
40
8
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1086/377567" target="_blank" rel="noreferrer noopener">http://doi.org/10.1086/377567</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
761-763
Issue
6
Volume
37
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Short-course Treatment Of Community-acquired Pneumonia
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-09
Subject
The topic of the resource
ciprofloxacin; Immunology; Infectious Diseases; levofloxacin; Microbiology; pharmacodynamics; resolution; therapy; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
Mandell L A; File T M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1086/377567" target="_blank" rel="noreferrer noopener">10.1086/377567</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
ciprofloxacin
Clinical Infectious Diseases
File T M
Immunology
Infectious Diseases
Levofloxacin
Mandell L A
Microbiology
pharmacodynamics
resolution
therapy
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00523.2007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00523.2007</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L399-L400
Issue
3
Volume
294
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Variations In Enac Subunit Composition May Determine Amiloride Sensitivity And Beta-adrenergic Stimulation Of Lung Fluid Absorption
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-03
Subject
The topic of the resource
airway epithelia; alveolar; cftr; channels; clearance; mice; Physiology; pulmonary edema; resolution; Respiratory System; sodium; transport
Creator
An entity primarily responsible for making the resource
Folkesson H G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00523.2007" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00523.2007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
airway epithelia
alveolar
American Journal of Physiology-Lung Cellular and Molecular Physiology
cftr
channels
clearance
Folkesson H G
Mice
Physiology
pulmonary edema
resolution
Respiratory System
Sodium
transport
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1185/030079904x2558" target="_blank" rel="noreferrer noopener">http://doi.org/10.1185/030079904x2558</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1473-1481
Issue
9
Volume
20
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical Implications Of 750mg, 5-day Levofloxacin For The Treatment Of Community Acquired Pneumonia
Publisher
An entity responsible for making the resource available
Current Medical Research and Opinion
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-09
Subject
The topic of the resource
adults; antimicrobial therapy; community-acquired pneumonia; controlled-trial; critical pathway; early switch; General & Internal Medicine; guidelines; levofloxacin; management; oral antibiotics; Research & Experimental Medicine; resolution; short-course; symptom
Creator
An entity primarily responsible for making the resource
File T M; Milkovich G; Tennenberg A M; Xiang J X; Khashab M M; Zadeikis N
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1185/030079904x2558" target="_blank" rel="noreferrer noopener">10.1185/030079904x2558</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
adults
antimicrobial therapy
Community-acquired pneumonia
controlled-trial
critical pathway
Current medical research and opinion
early switch
File T M
General & Internal Medicine
guidelines
Khashab M M
Levofloxacin
Management
Milkovich G
oral antibiotics
Research & Experimental Medicine
resolution
short-course
symptom
Tennenberg A M
Xiang J X
Zadeikis N
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/10.qco.0000124363.27345.46" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/10.qco.0000124363.27345.46</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
105-107
Issue
2
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Shorter Course Therapy Of Serious Respiratory Infections: New Data For New Approaches To Management
Publisher
An entity responsible for making the resource available
Current Opinion in Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
adults; antibiotic-therapy; carriage; Infectious Diseases; meningococcal disease; randomized-trial; resolution; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
File T M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/10.qco.0000124363.27345.46" target="_blank" rel="noreferrer noopener">10.1097/10.qco.0000124363.27345.46</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
adults
antibiotic-therapy
carriage
Current opinion in infectious diseases
File T M
Infectious Diseases
meningococcal disease
randomized-trial
resolution
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
185-188
Issue
2
Volume
19
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ventilator-associated pneumonia: gearing towards shorter-course therapy
Publisher
An entity responsible for making the resource available
Current Opinion in Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
pneumonia; Infectious Diseases; trial; infection; antibiotic-therapy; resolution; Antimicrobial therapy; duration of therapy; pseudomonas-aeruginosa; ventilator-associated
Creator
An entity primarily responsible for making the resource
Chua T D; File T M
Description
An account of the resource
Purpose of review The studies that are reviewed in this article have all concluded that a shorter duration of antibiotic therapy (7-8 days) may be adequate in the treatment of the majority of patients with ventilator-associated pneumonia, and does not confer an increased incidence of mortality. Recent findings Ventilator-associated pneumonia has traditionally been treated with at least 2 weeks of antimicrobial therapy. With the increasing emergence of multi-drug-resistant pathogens, however, efforts have been directed at minimizing the duration of therapy. Several studies have emerged over the last few years aiming to shorten the duration of antimicrobial therapy for ventilator-associated pneumonia. Summary The minimum effective duration of antibiotic therapy, however, remains unclear. Further studies geared towards determining this are needed.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2006
antibiotic-therapy
antimicrobial therapy
Chua T D
Current opinion in infectious diseases
duration of therapy
File T M
Infection
Infectious Diseases
Journal Article or Conference Abstract Publication
Pneumonia
pseudomonas-aeruginosa
resolution
trial
ventilator-associated
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1378/chest.120.1.271" target="_blank" rel="noreferrer noopener">http://doi.org/10.1378/chest.120.1.271</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
271-274
Issue
1
Volume
120
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rapid alveolar epithelial fluid clearance following lung lavage in pulmonary alveolar proteinosis
Publisher
An entity responsible for making the resource available
Chest
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-07
Subject
The topic of the resource
injury; liquid clearance; Respiratory System; transport; General & Internal Medicine; catecholamines; anesthetized sheep; channels; edema; mechanisms; resolution; rat lung; alveolar epithelial fluid transport; lung lavage; phospholipoproteinosis pulmonary edema; pulmonary alveolar
Creator
An entity primarily responsible for making the resource
Chesnutt M S; Nuckton T J; Golden J; Folkesson H G; Matthay M A
Description
An account of the resource
Study objective: To measure the in vivo rate of alveolar epithelial fluid clearance of the human lung in patients with pulmonary alveolar phospholipoproteinosis (PAP). Design: Prospective clinical study. Setting: The medical-surgical ICUs of a university teaching hospital. Patients: Four patients with idiopathic PAP requiring therapeutic lung lavage. Interventions: Large-volume lung lavage with isotonic saline solution using fiberoptic bronchoscopy followed by serial sampling of alveolar fluid using a wedged bronchial catheter. Measurements and results: The rate of alveolar epithelial fluid clearance was calculated by measuring the concentration of protein in sequential samples. Alveolar epithelial fluid clearance over the first hour after lung lavage was 53 +/- 14% (mean +/- SD). Sequential samples in two patients indicated a sustained high rate of clearance over several hours. Plasma and alveolar fluid epinephrine levels were in the normal range in two patients. Conclusions and significance: Alveolar fluid clearance is rapid after lung lavage in patients with PAP and appears to be driven by catecholamine-independent mechanisms. The rapid rate of alveolar epithelial fluid transport explains why patients with PAP tolerate large-volume lung lavage.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1378/chest.120.1.271" target="_blank" rel="noreferrer noopener">10.1378/chest.120.1.271</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2001
alveolar epithelial fluid transport
anesthetized sheep
catecholamines
channels
Chesnutt M S
Chest
Edema
Folkesson H G
General & Internal Medicine
Golden J
Injury
Journal Article or Conference Abstract Publication
liquid clearance
lung lavage
Matthay M A
mechanisms
Nuckton T J
phospholipoproteinosis pulmonary edema
pulmonary alveolar
rat lung
resolution
Respiratory System
transport
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/japplphysiol.00275.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/japplphysiol.00275.2002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1875-1880
Issue
5
Volume
93
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Title
A name given to the resource
Lung edema clearance: 20 years of progress selected contribution: Long-term effects of beta(2)-adrenergic receptor stimulation on alveolar fluid clearance in mice
Publisher
An entity responsible for making the resource available
Journal of Applied Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
acute lung injury; alveolar; beta-adrenergic-receptor; desensitization; down-regulation; epithelium; hydrostatic pulmonary-edema; in-vivo; liquid clearance; lung fluid balance; messenger-rna; Physiology; pulmonary edema; rat lung; resolution; sodium transport; Sport Sciences
Creator
An entity primarily responsible for making the resource
Sartori C; Fang X; McGraw D W; Koch P; Snider M E; Folkesson H G; Matthay M A
Description
An account of the resource
Stimulation of active fluid transport with beta-adrenergic receptor (betaAR) agonists can accelerate the resolution of alveolar edema. However, chronic betaAR-agonist administration may cause betaAR desensitization and downregulation that may impair physiological responsiveness to betaAR-agonist stimulation. Therefore, we measured baseline and terbutaline- (10(-3) M) stimulated alveolar fluid clearance in mice that received subcutaneously (miniosmotic pumps) either saline or albuterol (2 mg.kg(-1).day(-1)) for 1, 3, or 6 days. Continuous albuterol administration increased plasma albuterol levels (10(-5) M), an effect that was associated with 1) a significant decrease in betaAR density and 2) attenuation, but not ablation, of maximal terbutaline- induced cAMP production. Forskolin-mediated cAMP-release was unaffected. Continuous albuterol infusion stimulated alveolar fluid clearance on day 1 but did not increase alveolar fluid clearance on days 3 and 6. However, terbutaline- stimulated alveolar fluid clearance in albuterol-treated mice was not reduced compared with saline-treated mice. Despite significant reductions in betaAR density and agonist-mediated cAMP production by long-term betaAR-agonist exposure, maximal betaAR-agonist-mediated increase in alveolar fluid clearance is not diminished in mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/japplphysiol.00275.2002" target="_blank" rel="noreferrer noopener">10.1152/japplphysiol.00275.2002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2002
acute lung injury
alveolar
beta-adrenergic-receptor
Desensitization
Down-Regulation
Epithelium
Fang X
Folkesson H G
hydrostatic pulmonary-edema
in-vivo
Journal Article
Journal of Applied Physiology
Koch P
liquid clearance
lung fluid balance
Matthay M A
McGraw D W
messenger-rna
Physiology
pulmonary edema
rat lung
resolution
Sartori C
Snider M E
sodium transport
Sport Sciences
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/01.ccm.0000201403.70636.0f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.ccm.0000201403.70636.0f</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
676-681
Issue
3
Volume
34
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-03
Subject
The topic of the resource
activation; alveolar epithelium; catecholamine; cells; cftr; cystic fibrosis transmembrane conductance regulator; General & Internal Medicine; glibenclamide; injury; liquid clearance; na+ transport; Norepinephrine; pulmonary edema; pulmonary edema; rat; resected human lung; resolution
Creator
An entity primarily responsible for making the resource
Sakuma T; Gu X; Wang Z; Maeda S; Sugita M; Sagawa M; Osanai K; Toga H; Ware L B; Folkesson G; Matthay M A
Description
An account of the resource
Objectives. Because several experimental studies have demonstrated that cyclic adenosine monophosphate generation following beta-adrenoceptor activation can markedly stimulate alveolar fluid clearance, we determined whether the endogenous levels of catecholamines that occur in the pulmonary edema fluid and plasma of patients with acute lung injury are high enough to stimulate alveolar fluid clearance in the human lung. Design: Observational clinical Study. Setting. Academic university hospital and laboratory. Patients: Twenty-one patients with acute pulmonary edema plus ex vivo human lungs. Interventions. Measurements of catecholamine levels in patient samples and controlled laboratory studies of the effects of these catecholamine levels on the rates of alveolar fluid clearance in ex vivo human lungs. Measurements and Main Results. The concentrations of both epinephrine and norepinephrine in the pulmonary edema fluid and plasma were similar to 10(-9) M (range of 1-8 x 10(-9) M) in hydrostatic pulmonary edema (n = 6) and acute lung injury patients (n = 15). We therefore tested whether 10(-9) M epinephrine or norepinephrine stimulated alveolar fluid clearance in isolated human lungs and found that these epinephrine or norepinephrine concentrations did not stimulate alveolar fluid clearance. However, higher concentrations of epinephrine (10(-7) M), but not norepinephrine (10(-7) M), significantly stimulated alveolar fluid clearance by 84% above control. Glibenclamide (10(-5) M) and CFTR(inh)-172 (10(-5) M), cystic fibrosis transmembrane conductance regulator inhibitors, completely inhibited the epinephrine-induced stimulation of alveolar fluid clearance. Conclusions. These results indicate that endogenous catecholamine concentrations in pulmonary edema fluid are probably not sufficient to stimulate alveolar fluid clearance. In contrast, administration of exogenous catecholamines into the distal airspaces can stimulate alveolar fluid clearance in the human lung, an effect that is mediated in part by cystic fibrosis transmembrane conductance regulator. Therefore, exogenous cyclic adenosine monophosphate-dependent stimulation will probably be required to accelerate the resolution of alveolar edema in the lungs of patients with pulmonary edema.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.ccm.0000201403.70636.0f" target="_blank" rel="noreferrer noopener">10.1097/01.ccm.0000201403.70636.0f</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2006
activation
alveolar epithelium
catecholamine
Cells
cftr
Critical care medicine
cystic fibrosis transmembrane conductance regulator
Folkesson G
General & Internal Medicine
glibenclamide
Gu X
Injury
Journal Article
liquid clearance
Maeda S
Matthay M A
na+ transport
Norepinephrine
Osanai K
pulmonary edema
rat
resected human lung
resolution
Sagawa M
Sakuma T
Sugita M
Toga H
Wang Z
Ware L B