1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/1120009x.2002.11782351" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/1120009x.2002.11782351</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
42-56
Volume
14
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Clinical and public health implications of macrolide-resistant Streptococcus pneumoniae
Publisher
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Journal of Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-07
Subject
The topic of the resource
Infectious Diseases; Pathology; united-states; Pharmacology & Pharmacy; in-vitro; Oncology; community-acquired pneumonia; macrolide resistance; streptococci; respiratory; pneumoniae; haemophilus-influenzae; moraxella-catarrhalis; tract infections; macrolides; otitis-media; group-a; erythromycin resistance; decreased susceptibility; initial antimicrobial therapy; pneumococcal resistance; S.; treatment failure
Creator
An entity primarily responsible for making the resource
Moellering R C; Consensus Working Grp
Description
An account of the resource
Macrolide resistance among Streptococcus pneumoniae is a growing global concern, although its specific impact on public health is not currently well defined. A Consensus Working Group was convened in March 2001 to address whether credible, scientific data substantiate macrolide resistance in S. pneumoniae as: (i) producing significant morbidity; (ii) creating attendant health and economic burdens; (iii) constituting a public health threat; and (iv) warranting intervention, including development of new antibiotics with efficacy against these strains. Despite the limitations of available clinical data, concern about the possibility of treatment failure with macrolides is being expressed in clinical practice and in formal treatment guidelines, threatening the important role of these agents in the treatment of respiratory tract infections. Further studies are required to monitor and control macrolide resistance and evaluate settings in which macrolide treatment failures are occurring, and new therapeutic interventions are needed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/1120009x.2002.11782351" target="_blank" rel="noreferrer noopener">10.1080/1120009x.2002.11782351</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2002
Community-acquired pneumonia
Consensus Working Grp
decreased susceptibility
erythromycin resistance
group-a
haemophilus-influenzae
in-vitro
Infectious Diseases
initial antimicrobial therapy
Journal Article or Conference Abstract Publication
Journal of Chemotherapy
macrolide resistance
macrolides
Moellering R C
moraxella-catarrhalis
oncology
otitis-media
Pathology
Pharmacology & Pharmacy
pneumococcal resistance
pneumoniae
respiratory
S.
streptococci
tract infections
Treatment Failure
united-states
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M016048" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M016048</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2234-2244
Issue
12
Volume
52
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner
Publisher
An entity responsible for making the resource available
Journal of Lipid Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-12
Subject
The topic of the resource
beta-oxidation; Biochemistry & Molecular Biology; birth-weight; diet-induced obesity; fatty-acid oxidation; hepatic steatosis; induced; insulin sensitivity; insulin-resistance; lipid-metabolism; liver; negative feedback-regulation; oxygen consumption; quotient; respiratory; retinoic acid; signaling pathways; skeletal-muscle
Creator
An entity primarily responsible for making the resource
Park Y J; Kim S C; Kim J; Anakk S; Lee J M; Tseng H T; Yechoor V; Park J; Choi J S; Jang H C; Lee K U; Novak C M; Moore D D; Lee Y K
Description
An account of the resource
Mixed background SHP(-/-) mice are resistant to diet-induced obesity due to increased energy expenditure caused by enhanced PGC-1 alpha expression in brown adipocytes. However, congenic SHP(-/-) mice on the C57BL/6 background showed normal expression of PGC-1 alpha and other genes involved in brown adipose tissue thermogenesis. Thus, we reinvestigated the impact of small heterodimer partner (SHP) deletion on diet-induced obesity and insulin resistance using congenic SHP(-/-) mice. Compared with their C57BL/6 wild-type counterparts, SHP(-/-) mice subjected to a 6 month challenge with a Western diet (WestD) were leaner but more glucose intolerant, showed hepatic insulin resistance despite decreased triglyceride accumulation and increased beta-oxidation, exhibited alterations in peripheral tissue uptake of dietary lipids, maintained a higher respiratory quotient, which did not decrease even after WestD feeding, and displayed islet dysfunction. Hepatic mRNA expression analysis revealed that many genes expressed higher in SHP(-/-) mice fed WestD were direct peroxisome proliferator-activated receptor alpha (PPAR alpha) targets. Indeed, transient transfection and chromatin immunoprecipitation verified that SHP strongly repressed PPAR alpha-mediated transactivation. SHP is a pivotal metabolic sensor controlling lipid homeostasis in response to an energy-laden diet through regulating PPAR alpha-mediated transactivation. The resultant hepatic fatty acid oxidation enhancement and dietary fat redistribution protect the mice from diet-induced obesity and hepatic steatosis but accelerate development of type 2 diabetes.-Park, Y. J., S. C. Kim, J. Kim, S. Anakk, J. M. Lee, H-T. Tseng, V. Yechoor, J. Park, J-S. Choi, H. C. Jang, K-U. Lee, C. M. Novak, D. D. Moore, and Y. K. Lee. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J. Lipid Res. 2011. 52: 2234-2244.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M016048" target="_blank" rel="noreferrer noopener">10.1194/jlr.M016048</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2011
Anakk S
beta-oxidation
Biochemistry & Molecular Biology
birth-weight
Choi J S
diet-induced obesity
fatty-acid oxidation
hepatic steatosis
Induced
insulin sensitivity
insulin-resistance
Jang H C
Journal Article
Journal of lipid research
Kim J
Kim S C
Lee J M
Lee K U
Lee Y K
lipid-metabolism
Liver
Moore D D
negative feedback-regulation
Novak C M
Oxygen Consumption
Park J
Park Y J
quotient
respiratory
retinoic acid
signaling pathways
skeletal-muscle
Tseng H T
Yechoor V