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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/mc.21860" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/mc.21860</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
304-317
Issue
4
Volume
52
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Black Currant Phytoconstituents Exert Chemoprevention Of Diethylnitrosamine-initiated Hepatocarcinogenesis By Suppression Of The Inflammatory Response
Publisher
An entity responsible for making the resource available
Molecular Carcinogenesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; cancer-cell proliferation; chemoprevention; cyclooxygenase-2; cyclooxygenase-2 inhibitors; gamma-glutamyl-transferase; heat-shock proteins; heat-shock proteins; hepatocarcinogenesis; human hepatocellular-carcinoma; inflammation; liver cancer; molecular chaperones; nf-kappa-b; nuclear factor-B; Oncology; ribes-nigrum; signaling; united-states
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Mandal A; Darvesh A S; Ohanyan V; Meszaros J G; Haznagy-Radnai E; Hohmann J; Bhatia D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/mc.21860" target="_blank" rel="noreferrer noopener">10.1002/mc.21860</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Bhatia D
Biochemistry & Molecular Biology
Bishayee A
cancer-cell proliferation
Chemoprevention
cyclooxygenase-2
cyclooxygenase-2 inhibitors
Darvesh A S
Department of Pharmaceutical Sciences
gamma-glutamyl-transferase
Háznagy-Radnai E
Heat-Shock Proteins
Hepatocarcinogenesis
Hohmann J
human hepatocellular-carcinoma
Inflammation
Liver cancer
Mandal A
Meszaros J G
Molecular carcinogenesis
molecular chaperones
NEOMED College of Pharmacy
nf-kappa-b
nuclear factor-B
Ohanyan V
oncology
ribes-nigrum
Signaling
Thoppil R J
united-states
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/mc.21860" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/mc.21860</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
304-317
Issue
4
Volume
52
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Black Currant Phytoconstituents Exert Chemoprevention Of Diethylnitrosamine-initiated Hepatocarcinogenesis By Suppression Of The Inflammatory Response
Publisher
An entity responsible for making the resource available
Molecular Carcinogenesis
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; cancer-cell proliferation; Chemoprevention; cyclooxygenase-2; cyclooxygenase-2 inhibitors; gamma-glutamyl-transferase; heat-shock proteins; heat-shock proteins; hepatocarcinogenesis; human hepatocellular-carcinoma; Inflammation; liver cancer; molecular chaperones; nf-kappa-b; nuclear factor-B; Oncology; ribes-nigrum; signaling; united-states
Creator
An entity primarily responsible for making the resource
Bishayee A; Thoppil R J; Mandal A; Darvesh A S; Ohanyan V; Meszaros J G; Haznagy-Radnai E; Hohmann J; Bhatia D
Description
An account of the resource
Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats although the underlying mechanisms are not fully understood. Our present study investigates the anti-inflammatory mechanisms of BCSE during DENA rat liver carcinogenesis. Dietary BCSE (100 or 500mg/kg) treatment for 22wk afforded a striking inhibition of DENA-induced hepatic gamma-glutamyl transpeptidase-positive preneoplastic foci in a dose-responsive fashion. There was a significant increase in hepatic expression of heat shock proteins (HSP70 and HSP90), cyclooxygenase-2, and nuclear factor-B (NF-B) in DENA-exposed rat livers. Dietary BCSE dose-dependently abrogated all these elevated inflammatory markers. The possible cardiotoxicity of BCSE was assessed by monitoring cardiac functions using transthoracic echocardiography. BCSE-mediated anti-inflammatory effects during rat liver carcinogenesis have been achieved without any cardiotoxicity. Our results provide convincing evidence, for the very first time, that suppression of the inflammatory cascade through modulation of the NF-B signaling pathway could be implicated, at least in part, in the chemopreventive effects of black currant bioactive phytoconstituents against experimental hepatocarcinogenesis. These results coupled with an excellent safety profile of BCSE support the development of black currant phytochemicals for the chemoprevention of inflammation-driven hepatocellular cancer. (c) 2011 Wiley Periodicals, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/mc.21860" target="_blank" rel="noreferrer noopener">10.1002/mc.21860</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Bhatia D
Biochemistry & Molecular Biology
Bishayee A
cancer-cell proliferation
Chemoprevention
cyclooxygenase-2
cyclooxygenase-2 inhibitors
Darvesh A S
Department of Pharmaceutical Sciences
gamma-glutamyl-transferase
Háznagy-Radnai E
Heat-Shock Proteins
Hepatocarcinogenesis
Hohmann J
human hepatocellular-carcinoma
Inflammation
Journal Article or Conference Abstract Publication
Liver cancer
Mandal A
Meszaros J G
Molecular carcinogenesis
molecular chaperones
NEOMED College of Pharmacy
nf-kappa-b
nuclear factor-B
Ohanyan V
oncology
ribes-nigrum
Signaling
Thoppil R J
united-states