1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/ehjci/ehaa946.1024" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ehjci/ehaa946.1024</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1024
Issue
2
Volume
41
ISSN
0195-668X
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ehjci/ehaa946.1024" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ehjci/ehaa946.1024</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
February 2021 List
NEOMED College
NEOMED College of Medicine Student
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence of occult right ventricular dysfunction in morbidly obese patients
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
Subject
The topic of the resource
obesity; Ventricular Dysfunction; endocardium; heart failure; pulmonary hypertension; Diagnostic Techniques; chronic heart failure; body mass index procedure; right-sided; right ventricular ejection fraction; myocardial dysfunction
Creator
An entity primarily responsible for making the resource
Kulifay SLKS;Lattanzio DSLD;Mikolich BMMB;Mikolich JRMR
Description
An account of the resource
Background Abnormalities of right ventricular (RV) strain have been shown to occur prior to impairment of global right ventricular function, measured by global RV ejection fraction (RVEF) in patients with increased RV afterload, such as pulmonary hypertension. Obesity is a form of increased afterload involving both the right and left cardiac circulations, raising suspicion that impaired RV strain may be an early indicator of myocardial dysfunction. Purpose This study was designed to assess impairment of RV strain in obese patients with normal right ventricular ejection fraction (RVEF) using cardiac MRI Fast SENC (strain encoded) pulse sequences. Methods An institutional cardiac imaging database was queried for all patients with body mass index (BMI) greater than 35 kg/m2 who underwent measurement of RV global longitudinal strain (GLS), RV global circumferential strain (GCS) and 37 segmental strain measurements using cardiac MRI Fast-SENC pulse sequences. Global RVEF was computed for all patients using a standard cardiac MRI method using non-automated hand drawn RV endocardial borders. Global and regional strain measurements were compared to a cohort of healthy volunteers who also underwent CMR Fast-SENC imaging. Abnormal myocardial strain was defined as a value greater than −17%. Results Of the 356 patients in the database, 48 had a BMI greater than 35 kg/m2. Mean RV GLS and GCS for the study cohort were −16.6 and −15.8 respectively. For healthy volunteers RV GLS and GCS were −20.8 and −19.0 respectively. Comparison of mean RV GLS and GCS of both groups were statistically significant ANOVA p<0.001. The number of normal RV segmental strain values was significantly decreased in obese patients when compared to the normal cohort, ANOVA p<0.001 (Figure 1). Furthermore, the prevalence of abnormal RV GCS in morbidly obese patients with normal RVEF greater than or equal to 40% was 84% (21 of 25 patients). Conclusions These findings suggest that morbidly many obese patients have occult RV dysfunction despite a normal RVEF. This occult RV dysfunction not only affects RV global GLS and GCS, but also the percentage of normal segmental strain values. Detection of occult RV dysfunction is of clinical significance in that it may provide an opportunity for treatment before development of symptomatic right heart failure.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/ehjci/ehaa946.1024" target="_blank" rel="noreferrer noopener">10.1093/ehjci/ehaa946.1024</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
Publisher
An entity responsible for making the resource available
European Heart Journal
2020
body mass index procedure
chronic heart failure
Diagnostic Techniques
endocardium
European Heart Journal
February 2021 List
Heart failure
journalArticle
Kulifay SLKS
Lattanzio DSLD
Mikolich BMMB
Mikolich JRMR
myocardial dysfunction
NEOMED College of Medicine Student
NEOMED Student Publications
Obesity
pulmonary hypertension
right ventricular ejection fraction
right-sided
Ventricular Dysfunction