1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1002/cne.25089" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.25089</a>
ISSN
1096-9861 0021-9967
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine Student
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Age, sex, and regional differences in scavenger receptor CD36 in the mouse brain: Potential relevance to cerebral amyloid angiopathy and Alzheimer's disease.
Publisher
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The Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-14
Subject
The topic of the resource
brain; aging; mouse; Alzheimer's disease; cerebral amyloid angiopathy; vasculature; CD36; Alzheimer' s disease
Creator
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Edler MK; Johnson CT; Ahmed HS; Richardson JR
Description
An account of the resource
Scavenger receptor CD36 contributes significantly to lipid homeostasis, inflammation, and amyloid deposition, while CD36 deficiency is associated with restored cerebrovascular function in an Alzheimer's disease (AD) mouse model. Yet the distribution of CD36 has not been examined in the brain. Here, we characterized CD36 gene and protein expression in the brains of young, middle aged, aged, and elderly male and female C57BL/6J mice. Age-related increases in CD36 mRNA expression were observed in the male hippocampus and female midbrain. Additionally, male mice had greater CD36 mRNA expression than females in the striatum, hippocampus, and midbrain. CD36 protein was primarily expressed intravascularly, and this expression differed by region, age, and sex in the mouse brain. Although male mice brains demonstrated an increase in CD36 protein with age in several cortices, basal ganglia, hippocampus, and midbrain, a decrease with age was observed in female mice in the same regions. These data suggest that distinctive age, region, and sex expression of CD36 in the brain may contribute to Aβ deposition and neuroinflammation in AD.
Identifier
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<a href="http://doi.org/10.1002/cne.25089" target="_blank" rel="noreferrer noopener">10.1002/cne.25089</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Aging
Ahmed HS
Alzheimer's disease
Alzheimer&apos
Brain
CD36
cerebral amyloid angiopathy
Edler MK
January 2021 List
Johnson CT
journalArticle
mouse
NEOMED College of Medicine Student
NEOMED Student Publications
Richardson JR
s disease
The Journal of comparative neurology
vasculature
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/cells10040957" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/cells10040957</a>
Issue
4
Volume
10
Search for Full-text
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3390/cells10040957" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3390/cells10040957</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
May 2021 List
NEOMED College
College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
NEOMED Postdoc Publications
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease
Publisher
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Cells
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-04
Subject
The topic of the resource
inflammation; TREM2; neurodegenerative diseases; microglia; neuroinflammation; Alzheimer’s disease; s disease; Alzheimer’
Creator
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Casali BT; Reed-Geaghan EG
Description
An account of the resource
Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer's disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.
Identifier
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<a href="http://doi.org/10.3390/cells10040957" target="_blank" rel="noreferrer noopener">10.3390/cells10040957</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2021
Alzheimer’s disease
Alzheimer’
Casali BT
Cells
Department of Pharmaceutical Sciences
Inflammation
journalArticle
May 2021 List
Microglia
NEOMED College of Pharmacy
NEOMED College of Pharmacy Postdoc
NEOMED Postdoc Publications
Neurodegenerative Diseases
Neuroinflammation
Reed-Geaghan EG
s disease
TREM2