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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/106002809502900901" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/106002809502900901</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
835-842
Issue
9
Volume
29
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
THROMBOCYTOPENIA IN INTENSIVE-CARE PATIENTS - A COMPREHENSIVE ANALYSIS OF RISK-FACTORS IN 314 PATIENTS
Publisher
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Annals of Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-09
Subject
The topic of the resource
vancomycin; Pharmacology & Pharmacy; antibodies; respiratory-distress syndrome; septicemia; heparin-associated thrombocytopenia; intravascular coagulation
Creator
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Bonfiglio M F; Traeger S M; Kier K L; Martin B R; Hulisz D T; Verbeck S R
Description
An account of the resource
OBJECTIVE: To define the incidence and severity of thrombocytopenia in a mixed medical-surgical population of critically ill patients and to examine factors that may be related to the development of thrombocytopenia. DESIGN: Retrospective chart review of 314 critically ill patients requiring at least 3 days of critical care. SETTING: A 17-bed combined medical-surgical intensive care unit (ICU) in a 560-bed tertiary care community hospital. PATIENTS: Medical and surgical patients admitted to the ICU. INTERVENTIONS: All medical records over the duration of the ICU stay were reviewed, All scheduled medications, including dosage and start/stop dates, were recorded. All platelet counts, placement of pulmonary artery catheters, liver function test results, and admission serum creatinine concentrations were collected. MEASUREMENT AND MAIN RESULTS: Thrombocytopenia (platelet count less than 200 x 10(9)/L) was observed frequently, but rarely reached a severe stage (7 patients). No single diagnostic category was significantly associated with thrombocytopenia alone, although the combination of sepsis syndrome/septic shock and respiratory failure was strongly correlated (p < 0.0001) with thrombocytopenia. Liver function abnormalities were correlated strongly with thrombocytopenia, and the majority of patients (5 of 7) with severe thrombocytopenia (less than 20 x 10(9)/L) were found to have concurrent severe alterations in liver function test results. Pulmonary artery catheter placement and heparin exposure were associated strongly with thrombocytopenia (p < 0.0001). Drug therapies that were correlated with thrombocytopenia included heparin and vancomycin (p < 0.05). Hemodynamic instability was correlated strongly with the presence and severity of thrombocytopenia. In a stepwise linear regression model, the admission platelet count accounted for the largest proportion of the variance (43%), followed by hemodynamic instability (8%) and the requirement for inotropic agents (2%). CONCLUSIONS: Thrombocytopenia in the critically ill occurs frequently, rarely reaches severely depressed concentrations, and primarily represents a manifestation of disease processes initiated prior to admission. Hemodynamic instability and/or heparin exposure appear to be the strongest identifiable correlates with thrombocytopenia. Although these may cause infrequent isolated cases, other specific drug causes of thrombocytopenia are not responsible for the majority of cases of thrombocytopenia in the critically ill.
Identifier
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<a href="http://doi.org/10.1177/106002809502900901" target="_blank" rel="noreferrer noopener">10.1177/106002809502900901</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1995
Annals of Pharmacotherapy
Antibodies
Bonfiglio M F
heparin-associated thrombocytopenia
Hulisz D T
intravascular coagulation
Journal Article or Conference Abstract Publication
Kier K L
Martin B R
Pharmacology & Pharmacy
respiratory-distress syndrome
septicemia
Traeger S M
vancomycin
Verbeck S R
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/00365549309008519" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/00365549309008519</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
403-408
Issue
4
Volume
25
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ALPHA-HEMOLYTIC STREPTOCOCCAL BACTEREMIA - A REVIEW OF 203 EPISODES DURING 1980-1991
Publisher
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Scandinavian Journal of Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993
Subject
The topic of the resource
blood cultures; Infectious Diseases; infective endocarditis; leukemia; neutropenic patients; septicemia; viridans streptococci
Creator
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Watanakunakorn C; Pantelakis J
Description
An account of the resource
This is a review of 203 episodes of alpha-hemolytic streptococcal bacteremia during a 12-year period (1980-91) in a large community teaching hospital in the USA. There were 87 male and 116 female patients, with ages ranging from newborn infants to a 96-year-old; 118 patients (58.1%) were 60 years or older. 31 patients had endocarditis, 93 had bacteremia, and 79 had polymicrobial bacteremia. Streptococcus sanguis, S. mitis, S. salivarius and S. intermedius accounted for 80% of the strains. Some strains were resistant to tetracycline, nafcillin, erythromycin or clindamycin. The overall mortality was 29.6% (60 of 203 patients). There was no significant difference in the mortality among patients with endocarditis, bacteremia, and polymicrobial bacteremia. Factors that adversely influenced the mortality rate were old age (60 years and older) and rapidly fatal or ultimately fatal underlying conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3109/00365549309008519" target="_blank" rel="noreferrer noopener">10.3109/00365549309008519</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1993
blood cultures
Infectious Diseases
infective endocarditis
Journal Article
Leukemia
neutropenic patients
Pantelakis J
Scandinavian Journal of Infectious Diseases
septicemia
viridans streptococci
Watanakunakorn C