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Text
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URL Address
<a href="http://doi.org/10.1258/jms.2009.009017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1258/jms.2009.009017</a>
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Pages
55-59
Issue
2
Volume
16
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Title
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The Ability Of The Quadruple Test To Predict Adverse Perinatal Outcomes In A High-risk Obstetric Population
Publisher
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Journal of Medical Screening
Date
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2009
2009
Subject
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alpha-fetoprotein; association; birth; down-syndrome; Environmental & Occupational Health; human chorionic-gonadotropin; intrauterine growth restriction; markers; maternal; preeclampsia; pregnancy; Public; serum inhibin
Creator
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Lao M R; Calhoun B C; Bracero L A; Wang Y; Seybold D J; Brace M; Hatjis C G
Description
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`Objective To determine the ability of the quadruple Down's syndrome screening test (quad screen) to predict other adverse perinatal outcomes (APO) in a high-risk obstetric population. Setting A tertiary medical centre in West Virginia. Methods We retrospectively reviewed 342 obstetric patients with quad screen data from a single clinic. The quad screen included maternal serum levels of alphafetoprotein (AFP), human chorionic gonadotrophin (hCG), uncongjugated oestriol (uE(3)) and inhibin A. The risk of APO was compared between patients with at least one abnormal marker versus no abnormal markers and >= 2 abnormal markers versus <2 abnormal markers. Abnormal markers were determined by cut-off values produced by Receiver Operator Characteristic (ROC) curves and the FASTER trial. Unadjusted and adjusted effects were estimated using logistic regression analysis. Results The risk of having an APO increased significantly for patients with abnormal markers by about three-fold using ROC and two-fold using FASTER trial thresholds. Conclusions The quad screen shows value in predicting risk of APO in high-risk patients.
Identifier
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<a href="http://doi.org/10.1258/jms.2009.009017" target="_blank" rel="noreferrer noopener">10.1258/jms.2009.009017</a>
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Journal Article or Conference Abstract Publication
2009
Alpha-fetoprotein
association
birth
Brace M
Bracero L A
Calhoun B C
down-syndrome
Environmental & Occupational Health
Hatjis C G
human chorionic-gonadotropin
intrauterine growth restriction
Journal Article or Conference Abstract Publication
Journal of Medical Screening
Lao M R
markers
maternal
Preeclampsia
Pregnancy
Public
serum inhibin
Seybold D J
Wang Y