Characterisation of Prostate Lesions Using Transrectal Shear Wave Elastography (SWE) Ultrasound Imaging: A Systematic Review.
Creator
Anbarasan Thineskrishna;Wei C;Bamber JC;Barr RG;Nabi G
Publisher
Cancers
Date
2021
2021-01-02
Description
Shear wave elastography is an ultrasound-based imaging modality that can delineate prostate lesions that are stiffer, possibly due to cancerous changes. Using evidence from 16 published studies, including more than 2200 patients with suspected or biopsy-proven prostate cancer, we showed that shear wave elastography has good sensitivity and specificity for the detection of prostate cancer.
Subject
ultrasound-based shear wave elastography (SWE) can non-invasively assess prostate tissue stiffness. This systematic review aims to evaluate SWE for the detection of prostate cancer (PCa) and compare diagnostic estimates between studies reporting the detection of all PCa and clinically significant PCa (csPCa). Methods: a literature search was performed using the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, and CINAHL databases. Studies evaluating SWE for the detection of PCa using histopathology as reference standard were included. Results: 16 studies including 2277 patients were included for review. Nine studies evaluated SWE for the detection of PCa using systematic biopsy as a reference standard at the per-sample level, with a pooled sensitivity and specificity of 0.85 (95% CI = 0.74–0.92) and 0.85 (95% CI = 0.75–0.91), respectively. Five studies evaluated SWE for the detection of PCa using histopathology of radical prostatectomy (RP) specimens as the reference standard, with a pooled sensitivity and specificity of 0.71 (95% CI = 0.55–0.83) and 0.74 (95% CI = 0.42–0.92), respectively. Sub-group analysis revealed a higher pooled sensitivity (0.77 vs. 0.62) and specificity (0.84 vs. 0.53) for detection of csPCa compared to all PCa among studies using RP specimens as the reference standard. Conclusion: SWE is an attractive imaging modality for the detection of PCa
Advanced ultrasound in the diagnosis of prostate cancer.
Creator
Correas Jean-Michel; Halpern Ethan J; Barr Richard G; Ghai Sangeet; Walz Jochen; Bodard Sylvain; Dariane Charles; de la Rosette Jean
Publisher
World journal of urology
Date
2020
2020-04-18
Description
The diagnosis of prostate cancer (PCa) can be challenging due to the limited performance of current diagnostic tests, including PSA, digital rectal examination and transrectal conventional US. Multiparametric MRI has improved PCa diagnosis and is recommended prior to biopsy; however, mp-MRI does miss a substantial number of PCa. Advanced US modalities include transrectal prostate elastography and contrast-enhanced US, as well as improved B-mode, micro-US and micro-Doppler techniques. These techniques can be combined to define a novel US approach, multiparametric US (mp-US). Mp-US improves PCa diagnosis but is not sufficiently accurate to obviate the utility of mp-MRI. Mp-US using advanced techniques and mp-MRI provide complementary information which will become even more important in the era of focal therapy, where precise identification of PCa location is needed.
Subject
active surveillance; computer-aided diagnosis; contrast-enhanced ultrasound; Contrast-enhanced US; Dispersion imaging; Fusion imaging; initial evaluation; Micro-ultrasound; mp-MRI; mp-US; multiparametric mri; Prostate biopsy; Prostate cancer diagnosis; Prostate US elastography; Prostate US elastography; radical prostatectomy; reactive stroma; real-time elastography; shear-wave elastography; transrectal ultrasound