1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nlm.2003.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nlm.2003.10.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
105-114
Issue
2
Volume
81
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task
Publisher
An entity responsible for making the resource available
Neurobiology of Learning and Memory
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-03
Subject
The topic of the resource
2 forms; activation; anesthetized rats; antagonists cpp; area ca1; Behavioral Sciences; hippocampus; in-vivo; learning; long-term potentiation; ltp; ltp; Neurosciences & Neurology; nmdaLTP; Psychology; spatial; spatial memory; synaptic plasticity; vdccLTP
Creator
An entity primarily responsible for making the resource
Woodside B L; Borroni A M; Hammonds M D; Teyler T J
Description
An account of the resource
Activity dependent calcium entry into neurons can initiate a form of synaptic plasticity called long-term potentiation (LTP). This phenomenon is considered by many to be one possible cellular mechanism underlying learning and memory. The calcium entry that induces this phenomenon can occur when N-methyl-D-aspartate receptors (NMDARs) and/or voltage-dependent calcium channels (VDCCs) are activated. While much is known about synaptic plasticity and the mechanisms that are triggered by activation of these two Ca2+ channels, it is unclear what roles they play in learning. To better understand the role activation of these channels may play in learning we systemically administered pharmacological antagonists to block NMDARs, VDCCs, or both during training trials and retention tests in a radial arm maze task. Wistar rats injected with the NMDAR antagonist MK-801 (0.1 mg/kg) were impaired in the acquisition of this task. In contrast, rats injected with verapamil (10 mg/kg), an antagonist to VDCCs, acquired the task at the same rate as control animals, but were impaired on a 10-day retention test. A group of animals injected with both antagonists were unable to learn the task. The results suggest that each of the calcium channels and the processes they trigger are involved in a different stage of memory formation or expression. (C) 2003 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nlm.2003.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.nlm.2003.10.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2 forms
2004
activation
anesthetized rats
antagonists cpp
area ca1
Behavioral Sciences
Borroni A M
Hammonds M D
Hippocampus
in-vivo
Journal Article
Learning
Long-Term Potentiation
ltp
Neurobiology of learning and memory
Neurosciences & Neurology
nmdaLTP
Psychology
spatial
spatial memory
synaptic plasticity
Teyler T J
vdccLTP
Woodside B L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
9272-9276
Issue
24
Volume
20
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory
Publisher
An entity responsible for making the resource available
Journal of Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-12
Subject
The topic of the resource
hippocampus; rat; learning; verapamil; Neurosciences & Neurology; expression; neurons; long-term potentiation; environment; NMDA; MK-801; 2 forms; voltage-dependent calcium channel; nmdaLTP; spatial memory; vdccLTP; antagonist mk-801; working
Creator
An entity primarily responsible for making the resource
Borroni A M; Fichtenholtz H; Woodside B L; Teyler T J
Description
An account of the resource
This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2 forms
2000
antagonist mk-801
Borroni A M
Environment
expression
Fichtenholtz H
Hippocampus
Journal Article or Conference Abstract Publication
Journal of Neuroscience
Learning
Long-Term Potentiation
MK-801
Neurons
Neurosciences & Neurology
NMDA
nmdaLTP
rat
spatial memory
Teyler T J
vdccLTP
verapamil
voltage-dependent calcium channel
Woodside B L
Working