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40
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Text
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1113/JP281348">http://doi.org/10.1113/JP281348</a></td>
</tr></tbody></table>
Pages
1723-1724
Issue
6
Volume
599
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Biased synaptopathy as a central mechanism of age-related hearing loss.
Creator
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Lu Y
Publisher
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The Journal Of Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-01-31
Subject
The topic of the resource
Different properties of sounds are encoded by different subcortical circuits. Real-time auditory scene analysis requires multiple parallel streams of information encoded by these circuits to converge at the auditory cortex, forming auditory objects in space (Bregman 1994). This process begins at the cochlear nucleus (CN). As the first central auditory station, the CN receives information about sounds from the spiral ganglion neurons (SGNs) via the central synapses formed by the auditory nerve fibres (ANFs). A number of cell types exist in the CN, each of which assumes specialized morphology and physiology suitable for extracting certain features of sounds. Bushy cells are specialized in receiving and transmitting temporal information, which is critical for sound localization and speech comprehension. Much effort has been devoted to revealing the details of innervation in bushy cells, although the level of resolution has been limited by the lack of appropriate tools to distinguish different fibre types. In this issue of The Journal of Physiology, taking advantage of the molecular markers for distinct presynaptic fibres originating from the SGNs, Wang et al. (2021) investigated explicitly the innervation impinging upon single bushy cells in the mouse CN.
Identifier
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<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1113/JP281348">http://doi.org/10.1113/JP281348</a></td>
</tr></tbody></table>
2021
cochlear nucleus
Hearing Loss
spiral ganglion neurons
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10162-018-00690-3</a>
Pages
653–668
Issue
6
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.
Publisher
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Journal of the Association for Research in Otolaryngology : JARO
Date
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2018
2018-12
Subject
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calcium channel; hair cells; noise-induced hearing loss; spiral ganglion neurons; Stephania tetrandra; synapse; Tetrandrine
Creator
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Yu Yan; Hu Bing; Bao Jianxin; Mulvany Jessica; Bielefeld Eric; Harrison Ryan T; Neton Sarah A; Thirumala Partha; Chen Yingying; Lei Debin; Qiu Ziyu; Zheng Qingyin; Ren Jihao; Perez-Flores Maria Cristina; Yamoah Ebenezer N; Salehi Pezhman
Description
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Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca(2+) current in a dose-dependent manner and the half-blocking concentration was 0.6 + 0.1 muM. Consistent with previous findings that modulations of calcium-based signaling pathways have both prophylactic and therapeutic effects against neural trauma, NIHL was significantly diminished by TET administration. Importantly, TET has a long-lasting protective effect after noise exposure (48 weeks) in comparison to 2 weeks after noise exposure. The otoprotective effects of TET were achieved mainly by preventing outer hair cell damage and synapse loss between inner hair cells and spiral ganglion neurons. Thus, our data indicate that TET has great potential in the prevention and treatment of NIHL.
Identifier
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<a href="http://doi.org/10.1007/s10162-018-00690-3" target="_blank" rel="noreferrer noopener">10.1007/s10162-018-00690-3</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Bao Jianxin
Bielefeld Eric
calcium channel
Chen Yingying
Department of Anatomy & Neurobiology
Hair Cells
Harrison Ryan T
Hu Bing
Journal of the Association for Research in Otolaryngology : JARO
Lei Debin
Mulvany Jessica
NEOMED College of Medicine
Neton Sarah A
Noise-induced hearing loss
Perez-Flores Maria Cristina
Qiu Ziyu
Ren Jihao
Salehi Pezhman
spiral ganglion neurons
Stephania tetrandra
synapse
Tetrandrine
Thirumala Partha
Yamoah Ebenezer N
Yu Yan
Zheng Qingyin