1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050287" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050287</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
31-37
Issue
1
Volume
23
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of low dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-01
Subject
The topic of the resource
sepsis; injury; oxygen consumption; General & Internal Medicine; epinephrine; dopamine; index; septic shock; oxygen delivery; critically ill patients; consumption; blood flow; endotoxemia; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen; splanchnic oxygen delivery
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Bredle D L; Specht M; Spies C; Hannemann L; Reinhart K
Description
An account of the resource
Objective. To assess the effects of low-dose dopamine on splanchnic blood flow and splanchnic oxygen uptake in patients with septic shock. Design. Prospective, controlled trial. Setting. University hospital intensive care unit. Patients. 11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine. Measurements and main results: Systemic and splanchnic hemodynamics and oxygen transport were measured before and during addition of low-dose dopamine (3 mu g/kg per min). Low-dose dopamine had a marked effect on total body hemodynamics and oxygen transport. The fractional splanchnic flow at baseline ranged from 0.15 to 0.57. In 7 patients with a fractional splanchnic flow less than 0.30, low-dose dopamine increased splanchnic flow and splanchnic oxygen delivery and oxygen consumption. In 4 patients with a fractional splanchnic flow above 0.30, low-dose dopamine did not appear to change splanchnic blood flow. Conclusion: Low-dose dopamine has a potential beneficial effect on splanchnic blood flow and oxygen consumption in patients with septic shock, provided the fractional splanchnic flow is not already high before treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050287" target="_blank" rel="noreferrer noopener">10.1007/s001340050287</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
blood flow
Bredle D L
consumption
Critically Ill Patients
Dopamine
endotoxemia
Epinephrine
gastric-mucosal ph
General & Internal Medicine
Hannemann L
index
Indocyanine Green
Injury
Intensive Care Medicine
Journal Article or Conference Abstract Publication
Meierhellmann A
Oxygen Consumption
oxygen delivery
Reinhart K
sepsis
Septic shock
Specht M
Spies C
splanchnic
splanchnic oxygen
splanchnic oxygen delivery
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003246-199703000-00005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
399-404
Issue
3
Volume
25
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epinephrine impairs splanchnic perfusion in septic shock
Publisher
An entity responsible for making the resource available
Critical Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-03
Subject
The topic of the resource
sepsis; oxygen consumption; General & Internal Medicine; epinephrine; agents; septic shock; norepinephrine; oxygen delivery; critically ill patients; intramural ph; tissue oxygenation; blood flow; oxygen consumption; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen delivery; dobutamine; hepatic blood-flow; splanchnic oxygen consumption; vasoactive
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Reinhart K; Bredle D L; Specht M; Spies C D; Hannemann L
Description
An account of the resource
Objective: To assess the effects of epinephrine on splanchnic perfusion and splanchnic oxygen uptake in patients with septic shock. Design: Prospective, controlled trial. Setting: University hospital intensive care unit (ICU). Patients: Eight patients with septic shock, according to the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference, requiring treatment with vasopressors. Interventions: We compared in crossover design a 2-hr infusion of epinephrine with dobutamine plus norepinephrine in eight ICU patients with septic shock, Systemic and splanchnic hemodynamics and oxygen transport were measured before and during treatment with epinephrine. Measurements and Main Results: There was essentially no effect of epinephrine on the global parameters, except for increased lactate concentrations, There were marked effects on the regional variables; epinephrine caused lower splanchnic flow and oxygen uptake, lower mucosal pH, and higher hepatic vein lactate. Conclusion: We conclude that undesirable splanchnic effects on patients in whom that region is particularly fragile should be considered when using epinephrine for septic shock treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/00003246-199703000-00005" target="_blank" rel="noreferrer noopener">10.1097/00003246-199703000-00005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
agents
blood flow
Bredle D L
Critical care medicine
Critically Ill Patients
dobutamine
Epinephrine
gastric-mucosal ph
General & Internal Medicine
Hannemann L
hepatic blood-flow
Indocyanine Green
intramural ph
Journal Article or Conference Abstract Publication
Meierhellmann A
Norepinephrine
Oxygen Consumption
oxygen delivery
Reinhart K
sepsis
Septic shock
Specht M
Spies C D
splanchnic
splanchnic oxygen consumption
splanchnic oxygen delivery
tissue oxygenation
vasoactive
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s001340050264" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s001340050264</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1354-1359
Issue
12
Volume
22
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis
Publisher
An entity responsible for making the resource available
Intensive Care Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
sepsis; hypoxia; transport; General & Internal Medicine; metabolism; dopamine; septic shock; norepinephrine; failure; gut; oxygen consumption; endotoxemia; splanchnic oxygen delivery; splanchnic oxygen consumption; critically ill; extraction; splanchnic blood flow
Creator
An entity primarily responsible for making the resource
MeierHellmann A; Specht M; Hannemann L; Hassel H; Bredle D L; Reinhart K
Description
An account of the resource
Objective: To assess global and splanchnic blood flow and oxygen transport in patients with sepsis with and without norepinephrine treatment. Design: Prospective, clinical study. Setting: University hospital intensive care unit. Patients: A convenience sample of 15 septic shock patients treated with norepinephrine and 13 patients with severe sepsis who did not receive norepinephrine. Measurements and main results: There were no differences between the two groups in global haemodynamics and oxygen transport. Splanchnic blood flow and oxygen delivery (splanchnic DO2 303 +/- 43 ml/min per m(2)) and consumption (splanchnic VO2 100 +/- 13 ml/min per m(2)) were much higher in the septic shock group compared with the severe sepsis group (splanchnic DO2 175 +/- 19 ml/min per m(2), splanchnic VO2 61 +/- 6 ml/min per m(2)). Gastric mucosal pH was subnormal in both groups (septic shock 7.29 +/- 0.02, severe sepsis 7.25 +/- 0.02) with no significant difference. No significant differences between groups were detected in lactate values. Conclusion: These data confirm a redistribution of blood flow to the splanchnic region in sepsis that is even more pronounced in patients with septic shock requiring norepinephrine. However, subnormal gastric mucosal pH suggested inadequate oxygenation in parts of the splanchnic region due to factors other than splanchnic hypoperfusion. Progress in this area will depend on techniques that address not only total splanchnic blood flow, but also inter-organ flow distribution, intra-organ distribution, and other microcirculatory or metabolic malfunctions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s001340050264" target="_blank" rel="noreferrer noopener">10.1007/s001340050264</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bredle D L
critically ill
Dopamine
endotoxemia
extraction
failure
General & Internal Medicine
Gut
Hannemann L
Hassel H
hypoxia
Intensive Care Medicine
Journal Article or Conference Abstract Publication
Meierhellmann A
Metabolism
Norepinephrine
Oxygen Consumption
Reinhart K
sepsis
Septic shock
Specht M
splanchnic blood flow
splanchnic oxygen consumption
splanchnic oxygen delivery
transport