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Text
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URL Address
<a href="http://doi.org/10.1016/j.bcp.2007.07.009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2007.07.009</a>
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Pages
1413-1423
Issue
9
Volume
74
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Title
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Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity
Publisher
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Biochemical Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-11
Subject
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disease; Pharmacology & Pharmacy; microglial activation; parkinsons-disease; Substantia nigra; messenger-rna; dopamine; transporter; neurotoxicity; Neuroprotection; estrogen-receptor-alpha; induced; striatum; gender-differences; estradiol; Parkinson's; striatal tissue fragments; Substantia nigra
Creator
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Bourque M; Liu B; Dluzen D E; Di Paolo T
Description
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The selective estrogen receptor modulator tamoxifen and estradiol were shown to protect nigrostriatal dopamine concentration loss by methamphetamine in female mice whereas male mice were protected only by tamoxifen. The present study examined the protective properties of tarnoxifen in male mice on several nigrostriatal dopaminergic markers and body temperature. Intact male mice were administered 12.5 or 50 mu g tarnoxifen 24 h before methamphetamine treatment. Basal body temperatures of male mice remained unchanged by the tarnoxifen treatment. Methamphetamine reduced striatal dopamine and its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid concentrations, striatal and substantia nigra dopamine and vesicular monoamine transporter specific binding as well substantia nigra dopamine and vesicular monoamine transporter mRNA levels and increased striatal preproenkephalin mRNA levels. These methamphetamine effects were not altered by 12.5 mu g tarnoxifen except for increased striatal dopamine metabolites and turnover. Tamoxifen at 50 mu g reduced the methamphetamine effect on striatal dopamine concentration, dopamine transporter specific binding and prevented the increase in preproenkephalin mRNA levels; in the substantia nigra tamoxifen prevented the decrease of dopamine transporter mRNA levels. The present results show a tamoxifen dose-dependent prevention of loss of various dopaminergic markers against methamphetamine-induced toxicity in male mice. Since this is the only known hormonal protection of male mice against methamphetamine toxicity, these findings provide important new information on specific parameters of nigrostriatal dopaminergic function preserved by tarnoxifen. (C) 2007 Published by Elsevier Inc.
Identifier
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<a href="http://doi.org/10.1016/j.bcp.2007.07.009" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2007.07.009</a>
Format
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Journal Article or Conference Abstract Publication
2007
Biochemical pharmacology
Bourque M
Di Paolo T
Disease
Dluzen D E
Dopamine
estradiol
estrogen-receptor-alpha
gender-differences
Induced
Journal Article or Conference Abstract Publication
Liu B
messenger-rna
microglial activation
Neuroprotection
Neurotoxicity
Parkinson's
parkinsons-disease
Pharmacology & Pharmacy
striatal tissue fragments
striatum
SUBSTANTIA nigra
transporter