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Text
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URL Address
<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/jm070577s</a>
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Pages
6501-6506
Issue
26
Volume
50
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Title
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Conformational comparisons of a series of tachykinin peptide analogs
Publisher
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Journal of Medicinal Chemistry
Date
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2007
2007-12
Subject
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Pharmacology & Pharmacy; escherichia-coli; nmr; dynamics; nuclear-magnetic-resonance; substance-p receptor; agonists; neuropeptides; bradykinin; molecular modeling investigations; sds micelles
Creator
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Beard D J; Perrine S A; Phillips E; Hoque S; Conerly S; Tichenor C; Simmons M A; Young J K
Description
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Previous studies have shown differences in the biological activity and the structure of two naturally occurring tachykinin peptides, substance P (SP, RPKPQQFFGLM-NH2),and ranatachykinin C (RTKC, HNPASFIGLM-NH2). To further understand the basis for these differences, four analogs that selectively incorporate the amino acid differences between SP and RTKC have been synthesized for study. The four peptide analogs studied have the following amino acid sequences: SP2-11, also known as des-Arg SP (PKPQQFFGLM-NH2); Q5A-SP (RPKPAQFFGLM-NH2); Q6S-SP (RPKPQSFFGLM-NH2); and Q5AQ6S-SP (RPKPASFFGLM-NH2). Nuclear magnetic resonance spectroscopy and molecular modeling calculations were performed on SP, RTKC, SP2-11, Q5A-SP, Q6S-SP, and Q5AQ6S-SP to compare their conformational differences and similarities in the presence of the membrane mimetic system sodium dodecyl sulfate. The molecular modeling data of the analogs Q5A-SP and Q6S-SP show residues 1-3 have a random conformation and residues 4-8 have a helical structure, while the C-terminus contains a poly C-7 conformation that is similar to SP but different from RTKC., The molecular modeling data of the analogs SP2-11 and Q5AQ6S-SP show a continuous helix conformation for residues 4-11 at the C-terminus, which is different from SP but similar to RTKC. These structural differences are related to the functional differences of binding of the peptides at the SP receptor (NK1).
Identifier
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<a href="http://doi.org/10.1021/jm070577s" target="_blank" rel="noreferrer noopener">10.1021/jm070577s</a>
Format
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Journal Article or Conference Abstract Publication
2007
agonists
Beard D J
bradykinin
Conerly S
dynamics
escherichia-coli
Hoque S
Journal Article or Conference Abstract Publication
Journal of medicinal chemistry
molecular modeling investigations
neuropeptides
nmr
nuclear-magnetic-resonance
Perrine S A
Pharmacology & Pharmacy
Phillips E
sds micelles
Simmons M A
substance-p receptor
Tichenor C
Young J K