1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.890160108" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.890160108</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
66-75
Issue
1
Volume
16
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation Of Nmda Receptors In Hippocampal Area Ca1 By Low And High-frequency Orthodromic Stimulation And Their Contribution To Induction Of Long-term Potentiation
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
2-amino-5-phosphonovaleric acid; amino-acid receptors; cells; clamp; dentate gyrus; hippocampus; invitro rat hippocampus; kitten visual-cortex; n-methyl-d-aspartate receptor; Neurosciences & Neurology; pyramidal; responses; single-electrode voltage; slices; spinal-cord neurons; stimulation; synaptic plasticity; synaptic transmission; tetanic; time course
Creator
An entity primarily responsible for making the resource
Grover L M; Teyler T J
Description
An account of the resource
N-methyl-D-aspartate (NMDA) receptors are important in many instances of synaptic plasticity. In hippocampal area CA1, long-term potentiation (LTP) can be induced by both NMDA receptor-dependent and -independent mechanisms. Using intracellular recordings and single-electrode voltage clamp, we isolated and characterized NMDA receptor-mediated synaptic responses. NMDA receptor-mediated responses evoked by low frequency orthodromic stimulation were inhibited in a dose-dependent manner by the competitive antagonist D,L-2-amino-5-phosphonovaleric acid (APV). High frequency (tetanic) stimulation, which facilitates synaptic release of glutamate, failed to overcome the blockade of NMDA receptors by APV. Using extracellular recordings of field potentials, we studied the contribution of NMDA receptors to LTP induced by different patterns of tetanic stimulation. LTP was inhibited in a dose-dependent manner by APV, but was more sensitive to APV than were NMDA receptor-mediated synaptic responses. This most likely reflects a threshold for NMDA receptor activation in LTP induction. A component of LTP that resisted blockade by APV was induced by high (200 Hz), but not low (25 Hz), frequency tetanization. This NMDA receptor-independent component of LTP persisted for > 4 hours and accounted for approximately half the potentiation induced by 200 Hz tetanization. Procedures necessary to induce LTP at the Schaffer collateral/commissural synapses in area CA1 by both NMDA receptor-dependent and -independent mechanisms are now well characterized. Using the same neuronal population, it will be possible to ask if processes involved in the maintenance of LTP are shared even when LTP is induced through two different mechanisms. (C) 1994 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.890160108" target="_blank" rel="noreferrer noopener">10.1002/syn.890160108</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1994
2-amino-5-phosphonovaleric acid
amino-acid receptors
Cells
clamp
dentate gyrus
Grover L M
Hippocampus
invitro rat hippocampus
Journal Article or Conference Abstract Publication
kitten visual-cortex
N-methyl-D-aspartate receptor
Neurosciences & Neurology
pyramidal
responses
single-electrode voltage
slices
spinal-cord neurons
Stimulation
synapse
synaptic plasticity
Synaptic Transmission
tetanic
Teyler T J
time course
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2014.05.057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2014.05.057</a>
Pages
429–445
Volume
274
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Metabotropic glutamate receptors in auditory processing.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-08
Subject
The topic of the resource
Animals; Auditory Pathways/anatomy & histology/physiology; Auditory Perception/*physiology; auditory processing; excitotoxicity; Humans; Metabotropic Glutamate/*metabolism; mGluR; neuromodulation; neurotransmission; Receptors; synaptic plasticity
Creator
An entity primarily responsible for making the resource
Lu Y
Description
An account of the resource
As the major excitatory neurotransmitter used in the vertebrate brain, glutamate activates ionotropic and metabotropic glutamate receptors (mGluRs), which mediate fast and slow neuronal actions, respectively. Important modulatory roles of mGluRs have been shown in many brain areas, and drugs targeting mGluRs have been developed for the treatment of brain disorders. Here, I review studies on mGluRs in the auditory system. Anatomical expression of mGluRs in the cochlear nucleus has been well characterized, while data for other auditory nuclei await more systematic investigations at both the light and electron microscopy levels. The physiology of mGluRs has been extensively studied using in vitro brain slice preparations, with a focus on the lower auditory brainstem in both mammals and birds. These in vitro physiological studies have revealed that mGluRs participate in neurotransmission, regulate ionic homeostasis, induce synaptic plasticity, and maintain the balance between excitation and inhibition in a variety of auditory structures. However, very few in vivo physiological studies on mGluRs in auditory processing have been undertaken at the systems level. Many questions regarding the essential roles of mGluRs in auditory processing still remain unanswered and more rigorous basic research is warranted.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2014.05.057" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2014.05.057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Auditory Pathways/anatomy & histology/physiology
Auditory Perception/*physiology
auditory processing
Department of Anatomy & Neurobiology
excitotoxicity
Humans
Lu Y
Metabotropic Glutamate/*metabolism
mGluR
NEOMED College of Medicine
neuromodulation
Neuroscience
neurotransmission
Receptors
synaptic plasticity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/hipo.20048" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/hipo.20048</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
246-253
Issue
2
Volume
15
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
BDNF protects against stress-induced impairments in spatial learning and memory and UP
Publisher
An entity responsible for making the resource available
Hippocampus
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
adult-rat; brain; central-nervous-system; hippocampal pyramidal neurons; hippocampus; in-vivo; knockout mice; long-term potentiation; neuroprotection; Neurosciences & Neurology; neurotrophic factor; neurotrophins; rat; synaptic plasticity; synaptic transmission
Creator
An entity primarily responsible for making the resource
Radecki D T; Brown L M; Martinez J; Teyler T J
Description
An account of the resource
The present study investigated whether infusion of brain-derived neurotrophic factor (BDNF) could ameliorate stress-induced impairments in spatial learning and memory as well as hippocampal long-term potentiation (LTP) of rats. Chronic immobilization stress (2 h/day X 7 days) significantly impaired spatial performance in the Morris water maze, elevated plasma corticosterone, and attenuated LTP in hippocampal slices from these animals as compared with normal control subjects. BDNF was infused into the left hippocampus (0.5 mu l/h) for 14 days, beginning 7 days before the stress exposure. The BDNF group was protected from the deleterious effects of stress and performed at a level indistinguishable from normal control animals despite the presence of elevated corticosterone. BDNF alone and sham infusions had no effect on performance or LTP. These results demonstrate that spatial learning and memory, and LTP, a candidate neural substrate of learning and memory, are compromised during chronic stress, and may be protected by BDNF administration. (c) 2004 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/hipo.20048" target="_blank" rel="noreferrer noopener">10.1002/hipo.20048</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
adult-rat
Brain
Brown L M
central-nervous-system
hippocampal pyramidal neurons
Hippocampus
in-vivo
Journal Article
knockout mice
Long-Term Potentiation
Martinez J
Neuroprotection
Neurosciences & Neurology
neurotrophic factor
neurotrophins
Radecki D T
rat
synaptic plasticity
Synaptic Transmission
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.nlm.2003.10.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.nlm.2003.10.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
105-114
Issue
2
Volume
81
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task
Publisher
An entity responsible for making the resource available
Neurobiology of Learning and Memory
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-03
Subject
The topic of the resource
2 forms; activation; anesthetized rats; antagonists cpp; area ca1; Behavioral Sciences; hippocampus; in-vivo; learning; long-term potentiation; ltp; ltp; Neurosciences & Neurology; nmdaLTP; Psychology; spatial; spatial memory; synaptic plasticity; vdccLTP
Creator
An entity primarily responsible for making the resource
Woodside B L; Borroni A M; Hammonds M D; Teyler T J
Description
An account of the resource
Activity dependent calcium entry into neurons can initiate a form of synaptic plasticity called long-term potentiation (LTP). This phenomenon is considered by many to be one possible cellular mechanism underlying learning and memory. The calcium entry that induces this phenomenon can occur when N-methyl-D-aspartate receptors (NMDARs) and/or voltage-dependent calcium channels (VDCCs) are activated. While much is known about synaptic plasticity and the mechanisms that are triggered by activation of these two Ca2+ channels, it is unclear what roles they play in learning. To better understand the role activation of these channels may play in learning we systemically administered pharmacological antagonists to block NMDARs, VDCCs, or both during training trials and retention tests in a radial arm maze task. Wistar rats injected with the NMDAR antagonist MK-801 (0.1 mg/kg) were impaired in the acquisition of this task. In contrast, rats injected with verapamil (10 mg/kg), an antagonist to VDCCs, acquired the task at the same rate as control animals, but were impaired on a 10-day retention test. A group of animals injected with both antagonists were unable to learn the task. The results suggest that each of the calcium channels and the processes they trigger are involved in a different stage of memory formation or expression. (C) 2003 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.nlm.2003.10.003" target="_blank" rel="noreferrer noopener">10.1016/j.nlm.2003.10.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2 forms
2004
activation
anesthetized rats
antagonists cpp
area ca1
Behavioral Sciences
Borroni A M
Hammonds M D
Hippocampus
in-vivo
Journal Article
Learning
Long-Term Potentiation
ltp
Neurobiology of learning and memory
Neurosciences & Neurology
nmdaLTP
Psychology
spatial
spatial memory
synaptic plasticity
Teyler T J
vdccLTP
Woodside B L