1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jddst.2017.09.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jddst.2017.09.007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
436-443
Volume
41
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In Vivo Pharmacokinetics And Biodistribution Of Novel All-trans Retinoic Acid Derivative-loaded, Folate-modified Poly (l-amino Acid) Micelles
Publisher
An entity responsible for making the resource available
Journal of Drug Delivery Science and Technology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
cancer; cellular uptake; copolymer micelles; Drug; drug-delivery; Folate; nanoparticles; nanoparticles; Pharmacokinetics; Pharmacology & Pharmacy; polymeric micelles; targeted delivery; targeting; Tissue distribution
Creator
An entity primarily responsible for making the resource
Hong W X; Hu R F; Huang X C; Lu X Q; Czech T; Tang J H
Description
An account of the resource
Folate is widely used as a target ligand for tumor cells, and poly (L-aspartic acid)-b-poly-(L-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect, folate-conjugated PAA-PPA micelles were synthesized. To evaluate the hypothesis, we assessed the pharmacokinetics and biodistribution of.a new antitumor drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR) loaded into the micelles. We also observed in vivo imaging of 1,1'-dioctadecy1-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR) loaded micelles to confirm distribution. The results showed that ATPR-loaded, folate-modified PAA-PPA displayed a prolonged circulation half-life and iinproved the targeting effect. (C) 2017 Elsevier B.V. All tights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jddst.2017.09.007" target="_blank" rel="noreferrer noopener">10.1016/j.jddst.2017.09.007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Cancer
cellular uptake
copolymer micelles
Czech T
Drug
drug-delivery
Folate
Hong W X
Hu R F
Huang X C
Journal Article or Conference Abstract Publication
Journal of Drug Delivery Science and Technology
Lu X Q
Nanoparticles
pharmacokinetics
Pharmacology & Pharmacy
polymeric micelles
Tang J H
targeted delivery
Targeting
Tissue Distribution
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1208/s12249-014-0097-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1208/s12249-014-0097-8</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
741-752
Issue
3
Volume
15
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Light-Activatable Gold Nanoshells for Drug Delivery Applications
Publisher
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Aaps Pharmscitech
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-06
Subject
The topic of the resource
cancer nanotheranostics; drug delivery; gold nanoshells; growth-factor receptor; in-vitro; nanocarrier; nanoparticles; nf-kappa-b; Pharmacology & Pharmacy; photothermal-chemotherapy; release; surface-plasmon resonance; targeted delivery; theranostics; thermal therapy; triggered; triggered release
Creator
An entity primarily responsible for making the resource
Singhana B; Slattery P; Chen A; Wallace M; Melancon M P
Description
An account of the resource
Gold nanoshells (AuNSs) are currently being investigated as nanocarriers for drug delivery systems and have both diagnostic and therapeutic applications, including photothermal ablation, hyperthermia, drug delivery, and diagnostic imaging, particularly in oncology. AuNSs are valuable for their localized surface plasmon resonance, biocompatibility, low immunogenicity, and facile functionalization. AuNSs used for drug delivery can be spatially and temporally triggered to release controlled quantities of drugs inside the target cells when illuminated with a near-infrared (NIR) laser. Recently, many research groups have demonstrated that these AuNS complexes are able to deliver antitumor drugs (e.g., doxorubicin, paclitaxel, small interfering RNA, and single-stranded DNA) into cancer cells, which enhances the efficacy of treatment. AuNSs can also be functionalized with active targeting ligands such as antibodies, aptamers, and peptides to increase the particles' specific binding to the desired targets. This article reviews the current research on NIR light-activatable AuNSs used as nanocarriers for drug delivery systems and cancer theranostics.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1208/s12249-014-0097-8" target="_blank" rel="noreferrer noopener">10.1208/s12249-014-0097-8</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2014
AAPS PharmSciTech
cancer nanotheranostics
Chen A
Drug delivery
gold nanoshells
growth-factor receptor
in-vitro
Journal Article
Melancon M P
nanocarrier
Nanoparticles
nf-kappa-b
Pharmacology & Pharmacy
photothermal-chemotherapy
release
Singhana B
Slattery P
surface-plasmon resonance
targeted delivery
Theranostics
thermal therapy
triggered
triggered release
Wallace M