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Text
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URL Address
<a href="http://doi.org/10.1002/syn.890160108" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.890160108</a>
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Pages
66-75
Issue
1
Volume
16
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Title
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Activation Of Nmda Receptors In Hippocampal Area Ca1 By Low And High-frequency Orthodromic Stimulation And Their Contribution To Induction Of Long-term Potentiation
Publisher
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Synapse
Date
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1994
1994-01
Subject
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2-amino-5-phosphonovaleric acid; amino-acid receptors; cells; clamp; dentate gyrus; hippocampus; invitro rat hippocampus; kitten visual-cortex; n-methyl-d-aspartate receptor; Neurosciences & Neurology; pyramidal; responses; single-electrode voltage; slices; spinal-cord neurons; stimulation; synaptic plasticity; synaptic transmission; tetanic; time course
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Grover L M; Teyler T J
Description
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N-methyl-D-aspartate (NMDA) receptors are important in many instances of synaptic plasticity. In hippocampal area CA1, long-term potentiation (LTP) can be induced by both NMDA receptor-dependent and -independent mechanisms. Using intracellular recordings and single-electrode voltage clamp, we isolated and characterized NMDA receptor-mediated synaptic responses. NMDA receptor-mediated responses evoked by low frequency orthodromic stimulation were inhibited in a dose-dependent manner by the competitive antagonist D,L-2-amino-5-phosphonovaleric acid (APV). High frequency (tetanic) stimulation, which facilitates synaptic release of glutamate, failed to overcome the blockade of NMDA receptors by APV. Using extracellular recordings of field potentials, we studied the contribution of NMDA receptors to LTP induced by different patterns of tetanic stimulation. LTP was inhibited in a dose-dependent manner by APV, but was more sensitive to APV than were NMDA receptor-mediated synaptic responses. This most likely reflects a threshold for NMDA receptor activation in LTP induction. A component of LTP that resisted blockade by APV was induced by high (200 Hz), but not low (25 Hz), frequency tetanization. This NMDA receptor-independent component of LTP persisted for > 4 hours and accounted for approximately half the potentiation induced by 200 Hz tetanization. Procedures necessary to induce LTP at the Schaffer collateral/commissural synapses in area CA1 by both NMDA receptor-dependent and -independent mechanisms are now well characterized. Using the same neuronal population, it will be possible to ask if processes involved in the maintenance of LTP are shared even when LTP is induced through two different mechanisms. (C) 1994 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/syn.890160108" target="_blank" rel="noreferrer noopener">10.1002/syn.890160108</a>
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Journal Article or Conference Abstract Publication
1994
2-amino-5-phosphonovaleric acid
amino-acid receptors
Cells
clamp
dentate gyrus
Grover L M
Hippocampus
invitro rat hippocampus
Journal Article or Conference Abstract Publication
kitten visual-cortex
N-methyl-D-aspartate receptor
Neurosciences & Neurology
pyramidal
responses
single-electrode voltage
slices
spinal-cord neurons
Stimulation
synapse
synaptic plasticity
Synaptic Transmission
tetanic
Teyler T J
time course