Metastatic adenocarcinoma of the lung presenting as a soft tissue mass.
UNITED States; METASTASIS; ADENOCARCINOMA; EPIDERMAL cyst; LUNGS; TISSUES
Lung cancer is the leading cause of cancer death in the United States, with more than 230,000 new cases, and approximately 150,000 deaths estimated for 2018. Lung cancer most commonly metastasizes to the brain, liver, lungs, bone, and adrenal system; however, there have been several cases of spread to soft tissues, with an incidence rate of approximately 0.75-9%. The objective of this case report is to highlight an unusual presentation of metastatic adenocarcinoma of the lung. In this case report, patient presented with a 3 × 3 cm soft tissue mass on the back. The mass was slowly growing but had become more painful and wished to have it excised. Preoperatively, the mass was suspected to be a sebaceous cyst but intraoperatively had deep attachments and other suspicious findings. Pathology had a positive immunoprofile for metastatic adenocarcinoma favoring a lung primary. Given this presentation of metastases, the prognosis is poor with a survival time decreasing to around 5 months. Overall, this case reinforces the importance of sending all soft tissue masses for final pathology with accurate labeling and the importance of immunohistochemical testing in aiding the identification of the primary. [ABSTRACT FROM AUTHOR]
Yglesias B; Brooker M; DeVito R; Swiger A
Case Reports in Surgery
2021
2021-01-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1155/2021/8856503" target="_blank" rel="noreferrer noopener"></a>
Us Elastography Of Breast And Prostate Lesions
cancer detection; diagnosis; elasticity; images; Nuclear Medicine & Medical Imaging; pathological correlation; Radiology; real-time elastography; sonoelastography; systematic biopsy; tissues; ultrasound
Ginat D T; Destounis S V; Barr R G; Castaneda B; Strang J G; Rubens D J
Radiographics
2009
2009-11
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1148/rg.297095058" target="_blank" rel="noreferrer noopener">10.1148/rg.297095058</a>
Evaluation of Breast Lesions Using Sonographic Elasticity Imaging A Multicenter Trial
ultrasound; breast; elastography; Acoustics; sonoelastography; Radiology; Nuclear Medicine & Medical Imaging; tissues; benign; biopsy; breast lesion characterization
Objectives-The purpose of this study was to determine the sensitivity and specificity of real-time compression elasticity imaging in characterizing breast lesions as benign or malignant. Methods-A cohort of 578 women scheduled for sonographically guided biopsy of breast lesions were recruited from 6 sites under an Institutional Review Board-approved protocol. All participants received an elastogram, which displayed both the B-mode and elasticity images in real time. The longest dimensions of the lesion on the B-mode and elasticity imaging were measured. An elasticity imaging/B-mode ratio of at least 1.0 was considered positive for malignant lesions. The reference standard was based on biopsy. Results-A total of 635 lesions were imaged and biopsied. There were 222 (35%) malignant or borderline lesions and 413 (65%) benign lesions. The benign lesions were either cystic (145 [35%]) or solid (268 [65%]). Of the 222 malignant lesions, 219 had an elasticity imaging/B-mode ratio of at least 1.0. Of the 413 benign lesions, 361 had an elasticity imaging/B-mode ratio less than 1.0. These results corresponded to overall sensitivity of 98.6% and overall specificity of 87.4%. Individual site sensitivities ranged from 96.7% to 100% whereas specificities ranged from 66.7% to 95.4%. Conclusions-Elasticity imaging has high sensitivity in characterizing malignant lesions of the breast. Variability in specificity between sites and sonographers is possibly due to individual technique differences in performing elastography and measuring lesions. Further work in standardizing the technique is required.
Barr R G; Destounis S; Lackey L B; Svensson W E; Balleyguier C; Smith C
Journal of Ultrasound in Medicine
2012
2012-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.7863/jum.2012.31.2.281" target="_blank" rel="noreferrer noopener">10.7863/jum.2012.31.2.281</a>
Gene Expression in Slipped Capital Femoral Epiphysis
analysis; cancer; chondrocyte apoptosis; fixation; growth-plate; laser-capture microdissection; microarrays; molecular; Orthopedics; pcr; shear; Surgery; tissues
Background: Slipped capital femoral epiphysis is a poorly understood condition affecting adolescents. Prior studies have suggested that the etiology may be related to abnormal collagen in the growth plate cartilage, but we are not aware of any investigations analyzing collagen or other structural proteins on a molecular level in the affected tissue. This study was performed to evaluate expression of mRNA for key structural molecules in growth plate chondrocytes of patients with slipped capital femoral epiphysis. Methods: A core biopsy of the proximal femoral physis was performed in nine patients with slipped capital femoral epiphysis, and the specimens were compared with five specimens from the normal distal femoral and proximal tibial and fibular physes of age-matched patients treated surgically for a limb-length inequality. We utilized laser capture microdissection techniques followed by quantitative reverse transcription-polymerase chain reaction analysis to determine if a change or abnormality in type-II-collagen and/or aggrecan gene expression may be associated with slipped capital femoral epiphysis. With these techniques, we correlated chondrocyte spatial location and gene expression to provide greater insight into this pathological condition and a more complete understanding of growth plate biology in general. Results: Downregulation of both type-II collagen and aggrecan was found in the growth plates of the subjects with slipped capital femoral epiphysis when compared with the levels in the age-matched controls. In eight specimens from affected patients, the level of expression of type-II-collagen mRNA was, on the average (and standard error of the mean), 13.7% +/- 0.2% of that in four control specimens and the aggrecan level averaged only 26% 0.2% of the control aggrecan level. Conclusions: The decreases that we identified in type-II-collagen and aggrecan expression would affect the quantity, distribution, and organization of both components in a growth plate, but these changes could be associated with either the cause or the result of a slipped capital femoral epiphysis. Clinical Relevance: With further study with use of laser capture microdissection and quantitative reverse transcription-polymerase chain reaction, as well as other molecular biological approaches, these observations may be found to lead to a more complete understanding, and be pertinent to the treatment and possible prevention, of this serious adolescent disorder.
Scharschmidt T; Jacquet R; Weiner D; Lowder E; Schrickel T; Landis W J
Journal of Bone and Joint Surgery-American Volume
2009
2009-02
Journal Article
<a href="http://doi.org/10.2106/jbjs.g.00039" target="_blank" rel="noreferrer noopener">10.2106/jbjs.g.00039</a>