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Text
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<a href="http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m</a>
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Pages
157-163
Issue
2
Volume
35
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Title
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Amphiphilic networks .10. Diffusion of glucose and insulin (and nondiffusion of albumin) through amphiphilic membranes
Publisher
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Journal of Biomedical Materials Research
Date
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1997
1997-05
Subject
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cells; Drug Release; Engineering; Materials Science; pancreas; sequential co-polymers; telechelic polymers; transfer agents inifers
Creator
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Shamlou S; Kennedy J P; Levy R P
Description
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Select semipermeable amphiphilic membranes have been prepared and their diffusional characteristics for glucose, insulin, and albumin investigated. The membranes were prepared by cast copolymerization of a hydrophilic monomer (i.e., N,N-dimethyl acrylamide, or N,N-dimethylaminoethyl methacrylate) with the hydrophobic crosslinker methacrylate-ditelechelic polyisobutylene. The products have sufficient mechanical properties for the fabrication of swollen membranes, sheets, tubes, etc. Membranes have been identified which allowed the rapid simultaneous countercurrent diffusion of glucose (M-n = 180 Da) and insulin (M-n = 5733 Da) but did not allow albumin (Mn similar to 60,000 Da) to pass. Evidently, the effective molecular weight cutoff point of these membranes is in the 6-60-KDa range. (C) 1997 John Wiley & Sons, Inc.
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<a href="http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m" target="_blank" rel="noreferrer noopener">10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m</a>
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Journal Article
1997
Cells
Drug Release
Engineering
Journal Article
Journal of Biomedical Materials Research
Kennedy J P
Levy R P
Materials Science
Pancreas
sequential co-polymers
Shamlou S
telechelic polymers
transfer agents inifers