Herpes-simplex Virus - A Possible Etiologic Agent In Some Gastroduodenal Ulcer Disease
Creator
Kemker B P; Docherty J J; Delucia A; Ruf W; Lewis R D
Publisher
American Surgeon
Date
1992
1992-12
Description
There is increasing evidence that the herpes simplex virus may account for some gastric ulcer disease. To examine this possibility, 62 tissue biopsies from 21 patients were obtained during esophagogastroduodenoscopy for gastroduodenal ulcer disease and from one operative specimen during the procedure for perforation of a gastric ulcer. The samples were collected form the base and rim of the ulcer, as well as from apparently healthy tissue adjacent to the lesion. When the DNA was extracted from these tissues and hybridized to a herpes simplex virus-specific DNA probe, Positive results were obtained with 9.5 per cent (2 out of 21) of the patients with benign ulcers. Positive signals were obtained only with ulcer-associated tissues and never with healthy tissue. Hybridization also occurred with DNA from one ulcerative carcinoma in the study. These data suggest that a subset of ulcer disease may be caused by herpes simplex virus or that this virus may be secondarily associating with these lesions.
Subject
antibodies; dna; peptic-ulcer; Surgery; type-1
Identifier
n/a
Format
Journal Article or Conference Abstract Publication