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Text
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URL Address
<a href="http://doi.org/10.1016/j.juro.2012.09.096" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.juro.2012.09.096</a>
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Pages
1588-1594
Issue
4
Volume
189
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Title
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Impact Of Parturition On Chemokine Homing Factor Expression In The Vaginal Distention Model Of Stress Urinary Incontinence
Publisher
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Journal of Urology
Date
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2013
2013-04
Subject
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animal-model; cells; cytokines; deficiency; delivery; female; obstetric; pregnancy; rats; simulated childbirth injuries; urethra; urogenital organs; Urology & Nephrology; vagina; women; wounds and injuries
Creator
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Lenis A T; Kuang M; Woo L L; Hijaz A; Penn M S; Butler R S; Rackley R; Damaser M S; Wood H M
Description
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Purpose: Human childbirth simulated by vaginal distention is known to increase the expression of chemokines and receptors involved in stem cell homing and tissue repair. We hypothesized that pregnancy and parturition in rats contributes to the expression of chemokines and receptors after vaginal distention. Materials and Methods: We used 72 age matched female Lewis rats, including virgin rats with and without vaginal distention, and delivered rats with and without vaginal distention. Each rat was sacrificed immediately, or 3 or 7 days after vaginal distention and/or parturition, and the urethra was harvested. Relative expression of chemokines and receptors was determined by real-time polymerase chain reaction. Mixed models were used with the Bonferroni correction for multiple comparisons. Results: Vaginal distention up-regulated urethral expression of CCL7 immediately after injury in virgin and postpartum rats. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor were up-regulated only in virgin rats immediately after vaginal distention. CD191 expression was immediately up-regulated in postpartum rats without vaginal distention compared to virgin rats without vaginal distention. CD195 was up-regulated in virgin rats 3 days after vaginal distention compared to virgin rats without vaginal distention. CD193 and CXCR4 showed delayed up-regulation in virgin rats 7 days after vaginal distention. CXCL12 was up-regulated in virgin rats 3 days after vaginal distention compared to immediately after vaginal distention. Interleukin-8 and CD192 showed no differential expression. Conclusions: Vaginal distention results in up-regulation of the chemokines and receptors expressed during tissue injury, which may facilitate the spontaneous functional recovery previously noted. Pregnancy and delivery up-regulated CD191 and attenuated the expression of hypoxia inducible factor-1 alpha and vascular endothelial growth factor in the setting of vaginal distention, likely by decreasing hypoxia.
Identifier
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<a href="http://doi.org/10.1016/j.juro.2012.09.096" target="_blank" rel="noreferrer noopener">10.1016/j.juro.2012.09.096</a>
Format
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Journal Article or Conference Abstract Publication
2013
animal-model
Butler R S
Cells
Cytokines
Damaser M S
deficiency
Delivery
Female
Hijaz A
Journal Article or Conference Abstract Publication
Journal of Urology
Kuang M
Lenis A T
Obstetric
Penn M S
Pregnancy
Rackley R
Rats
simulated childbirth injuries
urethra
urogenital organs
Urology & Nephrology
vagina
Women
Woo L L
Wood H M
wounds and injuries