1
40
2
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Text
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URL Address
<a href="http://doi.org/10.5863/1551-6776-18.2.128" target="_blank" rel="noreferrer noopener">http://doi.org/10.5863/1551-6776-18.2.128</a>
Pages
128–136
Issue
2
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Valproic Acid and topiramate induced hyperammonemic encephalopathy in a patient with normal serum carnitine.
Publisher
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The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
topiramate; hyperammonemia; levocarnitine; serum carnitine; valproic acid
Creator
An entity primarily responsible for making the resource
Blackford Martha G; Do Stephanie T; Enlow Thomas C; Reed Michael D
Description
An account of the resource
A 17-year-old female developed hyperammonemic encephalopathy 2 weeks after valproic acid (VPA), 500 mg twice a day, was added to her regimen of topiramate (TPM), 200 mg twice a day. She presented to the emergency department (ED) with altered mental status, hypotension, bradycardia, and lethargy. Laboratory analysis showed mild non-anion gap hyperchloremic acidosis, serum VPA concentration of 86 mg/L, and urine drug screen result that was positive for marijuana. She was admitted to the pediatric intensive care unit for persistent symptoms, prolonged QTc, and medical history. Blood ammonia concentrations were obtained because of her persistent altered mental status, initially 94 mumol/L and a peak of 252 mumol/L. A serum carnitine profile was obtained at the time of hyperammonemia and was found to be normal (results were available postdischarge). VPA and TPM were discontinued on day 1 and day 2, respectively, as the patient's blood ammonia concentration remained elevated. On day 3, her mental status had returned to baseline, and blood ammonia concentrations trended downward; by day 4 her blood ammonia concentration was 23 mumol/L. VPA has been associated with numerous side effects including hyperammonemia and encephalopathy. Recently, drug interactions with TPM and VPA have been reported; however, serum carnitine concentrations have not been available. We discuss the possible mechanisms that VPA and TPM may affect serum ammonia and carnitine concentrations and the use of levocarnitine for patients or treating toxicity.
Identifier
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<a href="http://doi.org/10.5863/1551-6776-18.2.128" target="_blank" rel="noreferrer noopener">10.5863/1551-6776-18.2.128</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Blackford Martha G
Do Stephanie T
Enlow Thomas C
hyperammonemia
levocarnitine
Reed Michael D
serum carnitine
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
topiramate
valproic acid
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1345/aph.1K531" target="_blank" rel="noreferrer noopener">http://doi.org/10.1345/aph.1K531</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
403-407
Issue
3
Volume
42
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Use Of Intravenous Valproic Acid For Acute Migraine
Publisher
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Annals of Pharmacotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-03
Subject
The topic of the resource
headache; migraine headache; Pharmacology & Pharmacy; sodium valproate; valproic acid
Creator
An entity primarily responsible for making the resource
Frazee L A; Foraker K C
Identifier
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<a href="http://doi.org/10.1345/aph.1K531" target="_blank" rel="noreferrer noopener">10.1345/aph.1K531</a>
Format
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Journal Article or Conference Abstract Publication
2008
Annals of Pharmacotherapy
Department of Internal Medicine
Foraker K C
Frazee L A
Headache
Migraine headache
NEOMED College of Medicine
Pharmacology & Pharmacy
sodium valproate
valproic acid