1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s11517-008-0329-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11517-008-0329-8</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 433-442 Issue 5 Volume 46 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Chaotic behavior of the coronary circulation Publisher An entity responsible for making the resource available Medical & Biological Engineering & Computing Date A point or period of time associated with an event in the lifecycle of the resource 2008 2008-05 Subject The topic of the resource adenosine concentration; blood-flow; chaos; Computer Science; Coronary circulation; Coronary microcirculation; dependent protein-kinase; dynamic-response; Engineering; exercise; k-atp(+) channels; Mathematical & Computational Biology; Medical Informatics; modeling; nitric; nitric-oxide; oxide; time-series; vascular-resistance; vasodilation Creator An entity primarily responsible for making the resource Trzeciakowski J; Chilian W M Description An account of the resource The regulation of the coronary circulation is a complex paradigm in which many inputs that influence vasomotor tone have to be integrated to provide the coronary vasomotor adjustments to cardiac metabolism and to perfusion pressure. We hypothesized that the integration of many disparate signals that influence membrane potential of smooth muscle cells, calcium sensitivity of contractile filaments, receptor trafficking result in complex non-linear characteristics of coronary vasomotion. To test this hypothesis, we measured an index of vasomotion, flowmotion, the periodic fluctuations of flow that reflect dynamic changes in resistances in the microcirculation. Flowmotion was continuously measured in periods ranging from 15 to 40 min under baseline conditions, during antagonism of NO synthesis, and during combined purinergic and NOS antagonism in the beating heart of anesthetized open-chest dogs. Flowmotion was measured in arterioles ranging from 80 to 135 mu m in diameter. The signals from the flowmotion measurements were used to derive quantitative indices of non-linear behavior: power spectra, chaotic attractors, correlation dimensions, and the sum of the Lyapunov exponents (Kolmogorov-Sinai entropy), which reflects the total chaos and unpredictability of flowmotion. Under basal conditions, the coronary circulation demonstrated chaotic non-linear behavior with a power spectra showing three principal frequencies in flowmotion. Blockade of nitric oxide synthase or antagonism of purinergic receptors did not affect the correlation dimensions, but significantly increased the Kolmogorov-Sinai entropy, altered the power spectra of flowmotion, and changed the nature of the chaotic attractor. These changes are consistent with the view that certain endogenous controls, nitric oxide and various purines (AMP, ADP, ATP, adenosine) make the coronary circulation more predictable, and that blockade of these controls makes the control of flow less predictable and more chaotic. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s11517-008-0329-8" target="_blank" rel="noreferrer noopener">10.1007/s11517-008-0329-8</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2008 adenosine concentration blood-flow chaos Chilian W M Computer Science Coronary Circulation Coronary microcirculation dependent protein-kinase dynamic-response Engineering Exercise Journal Article k-atp(+) channels Mathematical & Computational Biology Medical & Biological Engineering & Computing Medical Informatics modeling nitric nitric-oxide oxide time-series Trzeciakowski J vascular-resistance vasodilation