1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1172/jci119502" target="_blank" rel="noreferrer noopener">http://doi.org/10.1172/jci119502</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-17
Issue
1
Volume
100
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Kallistatin is a potent new vasodilator
Publisher
An entity responsible for making the resource available
Journal of Clinical Investigation
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
Research & Experimental Medicine; expression; purification; endothelium; vasopressin; inhibitor; bradykinin; blood pressure; human tissue kallikrein; hypertensive rats; kallikrein; kallikrein-binding protein; kallistatin; kinins; renal pressure; vasorelaxation
Creator
An entity primarily responsible for making the resource
Chao J L; Stallone J N; Liang Y M; Chen L M; Wang D Z; Chao L
Description
An account of the resource
Kallistatin is a serine proteinase inhibitor which binds to tissue kallikrein and inhibits its activity, The aim of this study is to evaluate if kallistatin has a direct effect on the vasculature and on blood pressure homeostasis. We found that an intravenous bolus injection of human kallistatin caused a rapid, potent, and transient reduction of mean arterial blood pressure in anesthetized rats. Infusion of purified kallistatin (0.07-1.42 nmoVkg) into cannulated rat jugular vein produced a 20-85 mmHg reduction of blood pressure in a dose-dependent manner. Hoe 140, a bradykinin B-2-receptor antagonist, had no effect on the hypotensive effect of kallistatin yet it abolished the blood pressure-lowering effect of kinin and kallikrein. Relaxation of isolated aortic rings by kallistatin was observed in the presence (ED50 of 3.4 x 10(-9) M) and in the absence of endothelium (ED50 of 10(-9) M). Rat kallikrein-binding protein, but not kinin or kallikrein, induced vascular relaxation of aortic rings. Neither Hoe 140 nor N-omega-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, affected vasorelaxation induced by kallistatin. Kallistatin also caused dose-dependent vasodilation of the renal vasculature in the isolated, perfused rat kidney, Specific kallistatin-binding sites were identified in rat aorta by Scatchard plot analysis with a K-d of 0.25+/-0.07 nM and maximal binding capacity of 47.9+/-10.4 fmol/mg protein (mean+/-SEM, n = 3). These results indicate that kallistatin is a potent vasodilator which may function directly through a vascular smooth muscle mechanism independent of an endothelial bradykinin receptor. This study introduces the potential significance of kallistatin in directly regulating blood pressure to reduce hypertension.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1172/jci119502" target="_blank" rel="noreferrer noopener">10.1172/jci119502</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
Blood Pressure
bradykinin
Chao J L
Chao L
Chen L M
Endothelium
expression
human tissue kallikrein
hypertensive rats
inhibitor
Journal Article or Conference Abstract Publication
Journal of Clinical Investigation
kallikrein
kallikrein-binding protein
kallistatin
kinins
Liang Y M
purification
renal pressure
Research & Experimental Medicine
Stallone J N
vasopressin
vasorelaxation
Wang D Z
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Volume
9
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxytocin, Norepinephrine And Olfactory Bulb Mediated Recognition
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001
Subject
The topic of the resource
acetylcholine; acid; male-rats; maternal experience; memory; release; responses; sheep; social recognition; vasopressin
Creator
An entity primarily responsible for making the resource
Dluzen D E; Shang Y; Landgraf R
Identifier
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n/a
Format
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Book/Monograph
2001
Acetylcholine
acid
Dluzen D E
Landgraf R
male-rats
maternal experience
Memory
release
responses
Shang Y
Sheep
social recognition
vasopressin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr955</a>
Pages
76-88
Issue
2
Volume
11
ISSN
1923-2829 1923-2829
Search for Full-text
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.14740/cr955</a>
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Affiliated Hospital
Cleveland Clinic Akron General Hospital
Dublin Core
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Title
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An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome.
Publisher
An entity responsible for making the resource available
Cardiology research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
cardiac resynchronization therapy; Cardiorenal syndrome; cardiovascular events; Chronic kidney disease; Chronic kidney disease; decompensated heart-failure; Heart failure; impact; left-ventricular dysfunction; preserved ejection fraction; risk; vasopressin; worsening renal-function
Creator
An entity primarily responsible for making the resource
Raina Rupesh; Nair Nikhil; Chakraborty Ronith; Nemer Lena; Dasgupta Rahul; Varian Kenneth
Description
An account of the resource
Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which are hallmarks of its clinical phenotypes. This article explores the epidemiology, pathology, classification and treatment of each type of CRS.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.14740/cr955" target="_blank" rel="noreferrer noopener">10.14740/cr955</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
cardiac resynchronization therapy
Cardiology research
Cardiorenal syndrome
cardiovascular events
Chakraborty Ronith
Chronic kidney disease
Cleveland Clinic Akron General Hospital
Dasgupta Rahul
decompensated heart-failure
Department of Internal Medicine
Heart failure
impact
Journal Article
journalArticle
June 2020 Update I
left-ventricular dysfunction
Nair Nikhil
Nemer Lena
NEOMED College of Medicine
preserved ejection fraction
Raina Rupesh
Risk
Varian Kenneth
vasopressin
worsening renal-function