1
40
9
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.amjmed.2005.05.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.amjmed.2005.05.011</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
29-38
Volume
118
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Antimicrobial Treatment Of Lower Respiratory Tract Infections In The Hospital Setting
Publisher
An entity responsible for making the resource available
American Journal of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-07
Subject
The topic of the resource
5-day levofloxacin; acute exacerbations; antibiotic-therapy; antibiotics; chronic-bronchitis; community-acquired pneumonia; community-associated pneumonia; drug-interaction; General & Internal Medicine; healthcare-associated; hospital-acquired; open-label; quinolones; randomized-trial; streptococcus-pneumoniae; ventilator-associated; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
Grossman R F; Rotschafer J C; Tan J S
Description
An account of the resource
Respiratory tract infections (RTIs) that may require hospitalization include acute exacerbations of chronic bronchitis (AECB), community-acquired pneumonia (CAP), and hospital-acquired pneumonia (HAP), which includes ventilator-associated pneumonia (VAP). Healthcare-associated pneumonia (HCAP) is treated similar to HAP and may be considered with HAP. For CAP requiring hospitalization, the current guidelines for the treatments of RTIs generally recommend either a beta-lactam and macrolide combination or a fluoroquinolone. The respiratory fluoroquinolones (levofloxacin, gatifloxacin, moxifloxacin, and gemifloxacin) are excellent antibiotics due to high levels of susceptibility among gram-negative, gram-positive, and atypical pathogens. The fluoroquinolones are active against >98% of Streptococcus pneumoniae, including penicillin-resistant strains. Fluoroquinolones are also recommended for AECB requiring hospitalization. Evidence from clinical trials suggests that levofloxacin monotherapy is as efficacious as combination ceftriaxone-erythromycin therapy in the treatment of patients hospitalized with CAP. For early-onset HAP, VAP, and HCAP without the risk of multidrug resistance, ceftriaxone, ampicillin-sulbactam, ertapenem, or one of the fluoroquinolones is recommended. High-dose, short-course therapy regimens may offer improved treatment due to higher drug concentrations, more rapid killing, increased adherence, and the potential to reduce development of resistance. Recent studies have shown that short-course therapy with levofloxacin, azithromycin, or telithromycin in patients with CAP was effective, safe, and tolerable and may control the rate of resistance. (C) 2005 Elsevier Inc. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.amjmed.2005.05.011" target="_blank" rel="noreferrer noopener">10.1016/j.amjmed.2005.05.011</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2005
5-day levofloxacin
acute exacerbations
American Journal of Medicine
antibiotic-therapy
Antibiotics
chronic-bronchitis
Community-acquired pneumonia
community-associated pneumonia
drug-interaction
General & Internal Medicine
Grossman R F
healthcare-associated
hospital-acquired
Journal Article or Conference Abstract Publication
open-label
quinolones
randomized-trial
Rotschafer J C
streptococcus-pneumoniae
Tan J S
ventilator-associated
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1086/377567" target="_blank" rel="noreferrer noopener">http://doi.org/10.1086/377567</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
761-763
Issue
6
Volume
37
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Short-course Treatment Of Community-acquired Pneumonia
Publisher
An entity responsible for making the resource available
Clinical Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-09
Subject
The topic of the resource
ciprofloxacin; Immunology; Infectious Diseases; levofloxacin; Microbiology; pharmacodynamics; resolution; therapy; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
Mandell L A; File T M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1086/377567" target="_blank" rel="noreferrer noopener">10.1086/377567</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2003
ciprofloxacin
Clinical Infectious Diseases
File T M
Immunology
Infectious Diseases
Levofloxacin
Mandell L A
Microbiology
pharmacodynamics
resolution
therapy
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/10.qco.0000124363.27345.46" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/10.qco.0000124363.27345.46</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
105-107
Issue
2
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Shorter Course Therapy Of Serious Respiratory Infections: New Data For New Approaches To Management
Publisher
An entity responsible for making the resource available
Current Opinion in Infectious Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
adults; antibiotic-therapy; carriage; Infectious Diseases; meningococcal disease; randomized-trial; resolution; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
File T M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/10.qco.0000124363.27345.46" target="_blank" rel="noreferrer noopener">10.1097/10.qco.0000124363.27345.46</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
adults
antibiotic-therapy
carriage
Current opinion in infectious diseases
File T M
Infectious Diseases
meningococcal disease
randomized-trial
resolution
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-2
Issue
1
Volume
25
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Highlights From The 2016 Clinical Practice Guidelines By The Infectious Diseases Society Of America And The American Thoracic Society On Management Of Adults With Hospital-acquired And Ventilator-associated Pneumonia
Publisher
An entity responsible for making the resource available
Infectious Diseases in Clinical Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-01
Subject
The topic of the resource
guideline; hospital-acquired pneumonia; Immunology; Infectious Diseases; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
File T M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
File T M
guideline
hospital-acquired pneumonia
Immunology
Infectious Diseases
Infectious Diseases in Clinical Practice
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jhm.988" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jhm.988</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S22-S33
Volume
7
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Dublin Core
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Title
A name given to the resource
Duration And Cessation Of Antimicrobial Treatment
Publisher
An entity responsible for making the resource available
Journal of Hospital Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-01
Subject
The topic of the resource
acinetobacter-baumannii; antibiotic-therapy; antimicrobial resistance; case studies; catheter-related bloodstream; clinical-practice guidelines; clinical-practice guidelines; community-acquired pneumonia; complicated intra-abdominal; course; General & Internal Medicine; healthcare-associated pneumonia; hospital-acquired pneumonia; infection; infectious-diseases-society; intensive-care units; pseudomonas-aeruginosa; resistant; short-course therapy; staphylococcus-aureus bacteremia; streptococcus-pneumoniae; ventilator-acquired pneumonia; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
File T M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jhm.988" target="_blank" rel="noreferrer noopener">10.1002/jhm.988</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
acinetobacter-baumannii
antibiotic-therapy
Antimicrobial resistance
Case Studies
catheter-related bloodstream
clinical-practice guidelines
Community-acquired pneumonia
complicated intra-abdominal
course
File T M
General & Internal Medicine
healthcare-associated pneumonia
hospital-acquired pneumonia
Infection
infectious-diseases-society
intensive-care units
Journal of hospital medicine
pseudomonas-aeruginosa
resistant
short-course therapy
staphylococcus-aureus bacteremia
streptococcus-pneumoniae
ventilator-acquired pneumonia
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1089/neu.2010.1301" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/neu.2010.1301</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1009-1019
Issue
6
Volume
28
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Title
A name given to the resource
Impact Of Cervical Spine Management Brain Injury On Functional Survival Outcomes In Comatose, Blunt Trauma Patients With Extremity Movement And Negative Cervical Spine Ct: Application Of The Monte Carlo Simulation
Publisher
An entity responsible for making the resource available
Journal of Neurotrauma
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-06
Subject
The topic of the resource
clearance; computed tomography scanning; computed tomography; eastern association; fluoroscopy; General & Internal Medicine; guidelines; insult; intensive-care; models of injury; Neurosciences & Neurology; obtunded patients; pathophysiology; posttraumatic amnesia; secondary; severe head-injury; traumatic brain injury; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
Dunham C M; Carter K J; Castro F; Erickson B
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/neu.2010.1301" target="_blank" rel="noreferrer noopener">10.1089/neu.2010.1301</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
Carter K J
Castro F
clearance
computed tomography
computed tomography scanning
Dunham C M
eastern association
Erickson B
Fluoroscopy
General & Internal Medicine
guidelines
insult
intensive-care
Journal of neurotrauma
models of injury
Neurosciences & Neurology
obtunded patients
Pathophysiology
posttraumatic amnesia
Secondary
severe head-injury
Traumatic brain injury
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0019177" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0019177</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10-10
Issue
4
Volume
6
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Title
A name given to the resource
Comparative Analysis of Cervical Spine Management in a Subset of Severe Traumatic Brain Injury Cases Using Computer Simulation
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
mortality; stroke; risk-factors; Science & Technology - Other Topics; ventilator-associated pneumonia; blunt trauma; safe; mri; coma; immobilization
Creator
An entity primarily responsible for making the resource
Carter K J; Dunham C M; Castro F; Erickson B
Description
An account of the resource
Background: No randomized control trial to date has studied the use of cervical spine management strategies in cases of severe traumatic brain injury (TBI) at risk for cervical spine instability solely due to damaged ligaments. A computer algorithm is used to decide between four cervical spine management strategies. A model assumption is that the emergency room evaluation shows no spinal deficit and a computerized tomogram of the cervical spine excludes the possibility of fracture of cervical vertebrae. The study's goal is to determine cervical spine management strategies that maximize brain injury functional survival while minimizing quadriplegia. Methods/Findings: The severity of TBI is categorized as unstable, high risk and stable based on intracranial hypertension, hypoxemia, hypotension, early ventilator associated pneumonia, admission Glasgow Coma Scale (GCS) and age. Complications resulting from cervical spine management are simulated using three decision trees. Each case starts with an amount of primary and secondary brain injury and ends as a functional survivor, severely brain injured, quadriplegic or dead. Cervical spine instability is studied with one-way and two-way sensitivity analyses providing rankings of cervical spine management strategies for probabilities of management complications based on QALYs. Early collar removal received more QALYs than the alternative strategies in most arrangements of these comparisons. A limitation of the model is the absence of testing against an independent data set. Conclusions: When clinical logic and components of cervical spine management are systematically altered, changes that improve health outcomes are identified. In the absence of controlled clinical studies, the results of this comparative computer assessment show that early collar removal is preferred over a wide range of realistic inputs for this subset of traumatic brain injury. Future research is needed on identifying factors in projecting awakening from coma and the role of delirium in these cases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0019177" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0019177</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2011
blunt trauma
Carter K J
Castro F
coma
Dunham C M
Erickson B
immobilization
Journal Article or Conference Abstract Publication
Mortality
MRI
PloS one
risk-factors
safe
Science & Technology - Other Topics
stroke
ventilator-associated pneumonia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1089/sur.2017.219" target="_blank" rel="noreferrer noopener">http://doi.org/10.1089/sur.2017.219</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
846-853
Issue
8
Volume
18
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Dublin Core
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Title
A name given to the resource
A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway
Publisher
An entity responsible for making the resource available
Surgical Infections
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-11
Subject
The topic of the resource
adults; antibiotic stewardship; guidelines; infection; Infectious Diseases; Surgery; therapy; trial; ventilator-associated pneumonia
Creator
An entity primarily responsible for making the resource
Sartelli M; Kluger Y; Ansaloni L; Carlet J; Brink A; Hardcastle T C; Khanna A; Chicom-Mefire A; Rodriguez-Bano J; Nathwani D; Mendelson M; Watkins R R; Pulcini C; Beovic B; May A K; Itani K M F; Mazuski J E; Fry D E; Coccolini F; Rasa K; Montravers P; Eckmann C; Abbo L M; Abubakar S; Abu-Zidan F M; Adesunkanmi A K; Al-Hasan M N; Althani A A; Ticas J E A; Ansari S; Ansumana R; da Silva A R A; Augustin G; Bala M; Balogh Z J; Baraket O; Bassett M; Bellanova G; Beltran M A; Ben-Ishay O; Biffl W L; Boermeester M A; Brecher S M; Bueno J; Cainzos M A; Cairns K; Camacho-Ortiz A; Ceresoli M; Chandy S J; Cherry-Bukowiec J R; Cirocchi R; Colak E; Corcione A; Cornely O A; Cortese F; Cui Y F; Curcio D; Damaskos D; Das K; Delibegovic S; Deme-Trashvili Z; De Simone B; de Souza H P; De Waele J; Dhingra S; Diaz J J; Di Carlo I; Di Marzo F; Di Saverio S; Dogjani A; Dorj G; Dortet L; Duane T M; Dupont H; Egiev V N; Eid H O; Elmangory M; Marei H E; Enani M A; Escandon-Vargas K; Faro M P; Ferrada P; Foghetti D; Foianini E; Fraga G P; Frattima S; Gandhi C; Gattuso G; Giamarellou E; Ghnnam W; Gkiokas G; Girardis M; Goff D A; Gomes C A; Gomi H; Gronerth R I G; Guirao X; Guzman-Blanco M; Haque M; Hecker A; Hell M; Herzog T; Hicks L; Kafka-Ritsch R; Kao L S; Kanj S S; Kaplan L J; Kapoor G; Karamarkovic A; Kashuk J; Kenig J; Khamis F; Khokha V; Kiguba R; Kirkpatrick A W; Korner H; Koike K; Kok K Y Y; Kon K; Kong V; Inaba K; Ioannidis O; Isik A; Iskandar K; Labbate M; Labricciosa F M; Lagrou K; Lagunes L; Latifi R; Lasithiotakis K; Laxminarayan R; Lee J G; Leone M; Leppaniemi A; Li Y S; Liang S Y; Liau K H; Litvin A; Loho T; Lowman W; Machain G M; Maier R V; Manzano-Nunez R; Marinis A; Marmorale C; Martin-Loeches I; Marwah S; Maseda E; McFarlane M; de Melo R B; Melotti M R; Memish Z; Mertz D; Mesina C; Menichetti F; Mishra S K; Montori G; Moore E E; Moore F A; Naidoo N; Napolitano L; Negoi I; Nicolau D P; Nikolopoulos I; Nord C E; Ofori-Asenso R; Olaoye I; Omari A H; Ordonez C A; Ouadii M; Ouedraogo A S; Pagani L; Paiva J A; Parreira J G; Pata F; Pereira J; Pereira N R; Petrosillo N; Picetti E; Pintar T; Ponce-de-Leon A; Popovski Z; Poulakou G; Preller J; Guerrero A P; Pupelis G; Quiodettis M; Rawson T M; Reichert M; Reinhart K; Rems M; Rello J; Rizoli S; Roberts J; Rubio-Perez I; Ruppc E; Sakakushev B; Sall I; Kafil H S; Sanders J; Sato N; Sawyer R G; Scalea T; Scibe R; Scudeller L; Lohse H S; Sganga G; Shafiq N; Shah J N; Spigaglia P; Suroowan S; Tsioutis C; Sifri C D; Siribumrungwong B; Sugrue M; Talving P; Tan B K; Tarasconi A; Tascini C; Tilsed J; Timsit J F; Tumbarello M; Trung N T; Ulrych J; Uranues S; Velmahos G; Vereczkei A G; Viale P; Estape J V; Viscoli C; Wagenlehner F; Wright B J; Xiao Y H; Yuan K C; Zachariah S K; Zahar J R; Mergulhao P; Catena F; Members Global Alliance Infect Sur
Description
An account of the resource
This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use of antibiotic agents and antifungal agents in hospitals worldwide especially focusing on surgical infections. As such, it is our intent to raise awareness among healthcare workers and improve antimicrobial prescribing. To facilitate its dissemination, the declaration was translated in different languages.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1089/sur.2017.219" target="_blank" rel="noreferrer noopener">10.1089/sur.2017.219</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
Abbo L M
Abu-Zidan F M
Abubakar S
Adesunkanmi A K
adults
Al-Hasan M N
Althani A A
Ansaloni L
Ansari S
Ansumana R
antibiotic stewardship
Augustin G
Bala M
Balogh Z J
Baraket O
Bassett M
Bellanova G
Beltran M A
Ben-Ishay O
Beovic B
Biffl W L
Boermeester M A
Brecher S M
Brink A
Bueno J
Cainzos M A
Cairns K
Camacho-Ortiz A
Carlet J
Catena F
Ceresoli M
Chandy S J
Cherry-Bukowiec J R
Chicom-Mefire A
Cirocchi R
Coccolini F
Colak E
Corcione A
Cornely O A
Cortese F
Cui Y F
Curcio D
da Silva A R A
Damaskos D
Das K
de Melo R B
De Simone B
de Souza H P
De Waele J
Delibegovic S
Deme-Trashvili Z
Department of Internal Medicine
Dhingra S
Di Carlo I
Di Marzo F
Di Saverio S
Diaz J J
Dogjani A
Dorj G
Dortet L
Duane T M
DuPont H
Eckmann C
Egiev V N
Eid H O
Elmangory M
Enani M A
Escandon-Vargas K
Estape J V
Faro M P
Ferrada P
Foghetti D
Foianini E
Fraga G P
Frattima S
Fry D E
Gandhi C
Gattuso G
Ghnnam W
Giamarellou E
Girardis M
Gkiokas G
Goff D A
Gomes C A
Gomi H
Gronerth R I G
Guerrero A P
guidelines
Guirao X
Guzman-Blanco M
Haque M
Hardcastle T C
Hecker A
Hell M
Herzog T
Hicks L
Inaba K
Infection
Infectious Diseases
Ioannidis O
Isik A
Iskandar K
Itani K M F
Journal Article
Kafil H S
Kafka-Ritsch R
Kanj S S
Kao L S
Kaplan L J
Kapoor G
Karamarkovic A
Kashuk J
Kenig J
Khamis F
Khanna A
Khokha V
Kiguba R
Kirkpatrick A W
Kluger Y
Koike K
Kok K Y Y
Kon K
Kong V
Korner H
Labbate M
Labricciosa F M
Lagrou K
Lagunes L
Lasithiotakis K
Latifi R
Laxminarayan R
Lee J G
Leone M
Leppaniemi A
Li Y S
Liang S Y
Liau K H
Litvin A
Loho T
Lohse H S
Lowman W
Machain G M
Maier R V
Manzano-Nunez R
Marei H E
Marinis A
Marmorale C
Martin-Loeches I
Marwah S
Maseda E
May A K
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<a href="http://doi.org/10.1016/j.ijid.2012.12.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijid.2012.12.013</a>
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Pages
E398-E403
Issue
6
Volume
17
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Title
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Emergence of methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of late-onset nosocomial pneumonia in intensive care patients in the USA
Publisher
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International Journal of Infectious Diseases
Date
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2013
2013-06
Subject
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blood-stream infections; CA-MRSA; community-acquired pneumonia; Community-associated methicillin-resistant Staphylococcus aureus; Community-associated MRSA; disease; epidemiology; Infectious Diseases; Intensive care; molecular; mortality; MRSA; mrsa strains; Nosocomial pneumonia; outcomes; panton-valentine leukocidin; risk-factors; ventilator-associated pneumonia
Creator
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Pasquale T R; Jabrocki B; Salstrom S J; Wiemken T L; Peyrani P; Haque N Z; Scerpella E G; Ford K D; Zervos M J; Ramirez J A; File T M; Grp Impact-Hap Study
Description
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Objective: To compare demographic and clinical characteristics, and methicillin-resistant Staphylococcus aureus (MRSA) strain characteristics, in patients with early-onset (EO) and late-onset (LO) MRSA nosocomial pneumonia. Methods: This was a retrospective analysis of data from a multicenter observational study of nosocomial pneumonia patients admitted between November 2008 and July 2010. Laboratory analyses performed on MRSA isolates included confirmation of antimicrobial susceptibility and heteroresistance to vancomycin, USA typing, staphylococcal cassette chromosome (SCC) mec typing, and detection of Panton-Valentine leukocidin (PVL) genes. Results: We identified 134 patients; 42 (31%) had EO MRSA pneumonia and 92 (69%) had LO MRSA pneumonia. The patients in the LO group were more likely to have risk factors for multidrug-resistant pathogens (98% vs. 76%, p < 0.001). The MRSA USA300 strain was found with equal frequency in the EO and LO groups. Likewise, both groups had similar frequencies of isolates exhibiting PVL and SCCmec type IV. Conclusions: Our findings provide further evidence of the continued migration of community-associated MRSA into the healthcare setting in the USA. MRSA USA300 genotype has emerged as a significant cause of LO nosocomial pneumonia in intensive care units. Appropriate anti-MRSA antimicrobial therapy should be considered for both EO and LO hospital-acquired pneumonia and ventilator-associated pneumonia. (C) 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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<a href="http://doi.org/10.1016/j.ijid.2012.12.013" target="_blank" rel="noreferrer noopener">10.1016/j.ijid.2012.12.013</a>
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Journal Article
2013
blood-stream infections
CA-MRSA
Community-acquired pneumonia
Community-associated methicillin-resistant Staphylococcus aureus
Community-associated MRSA
Disease
Epidemiology
File T M
Ford K D
Grp Impact-Hap Study
Haque N Z
Infectious Diseases
intensive care
International Journal of Infectious Diseases
Jabrocki B
Journal Article
Molecular
Mortality
MRSA
mrsa strains
Nosocomial pneumonia
outcomes
panton-valentine leukocidin
Pasquale T R
Peyrani P
Ramirez J A
risk-factors
Salstrom S J
Scerpella E G
ventilator-associated pneumonia
Wiemken T L
Zervos M J