1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1093/ofid/ofz360.305" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofz360.305</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages S132-S133 Volume 6 ISSN 23288957 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/ofid/ofz360.305" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/ofid/ofz360.305</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> NEOMED College NEOMED College of Medicine NEOMED Department NEOMED Student Publications Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 230. Molecular Typing of Streptococcus pyogenes Isolates Collected at Mongolian Hospital (Ulaanbaatar, Mongolia). Publisher An entity responsible for making the resource available Open Forum Infectious Diseases Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-10-02 Subject The topic of the resource mortality; epidemiology; antibiotic resistance; medical; surveillance; genes; bacterial; morbidity; infection; molecular; mongolia; antimicrobial susceptibility; china; communicable diseases; DRUG resistance in bacteria; LOW-income countries; disclosure; polymerase chain reaction; CENTERS for Disease Control & Prevention (U.S.); clone cells; communicable diseases; disease outbreaks; ichthyosis; low income; MOLECULAR epidemiology; mongolia; multi-antibiotic resistance; sequence tagged sites; sodium thiosulfate; streptococcus pyogenes; streptococcus pyogenes; TOXIC shock syndrome; ULAANBAATAR (Mongolia); vaccine development; x-linked Creator An entity primarily responsible for making the resource Thapaliya Dipendra; Mackey Samantha; Kadariya Jhalka; Davaadash Bulgan; Smith Tara Description An account of the resource Background Streptococcus pyogenes is a significant cause of morbidity and mortality worldwide causing an estimated 1.8 million cases and 517,000 deaths each year. S. pyogenes infections disproportionately affect low-income countries where routine surveillance is not available. The objective of this study was to investigate the molecular epidemiology and antibiotic resistance of clinically relevant S. pyogenes isolates in Ulaanbaatar, Mongolia, to better understand the burden in this under-served population. Methods Clinical S. pyogenes isolates (n = 41) collected at the Bacteriological Reference Laboratory, National Center for Communicable Diseases, Ulaanbaatar, Mongolia, were cultured and characterized using PCR techniques. The emm gene was sequenced and emm type was assigned as per Centers for Disease Control and Prevention (CDC) methods and guideline. Multi-locus sequence typing (MLST) was carried out on selected isolates (n = 15). Antibiotic susceptibility testing (AST) was done via the Vitek-2 system as per manufacturer's instructions. Results We observed 18 distinct emm types among the 41 S. pyogenes isolates. stG6792.0 was the most common emm type, accounting for more than one-third of the isolates (15/41) followed by emm 2.0 (ST55) (5/41) and emm 82.0 (ST314) (2/41). A total of seven sequence types (STs) were detected among 15 tested isolates. The most common ST type was ST55 accounting for one-third of the isolates (5/15). Most of the isolates were susceptible to all tested drugs. Conclusion The findings of this study provided some insights regarding the molecular characteristics of S. pyogenes in Mongolia that will be crucial for future surveillance studies. Five isolates of this study had similar emm types (emm74.0, emm66.0, stG480.0, emm83.1, emm89.0) compared with a previous surveillance study. emm89.0 (ST101) was a major epidemiological isolate in the United States between 2000 and 2004. emm89.0 was also implicated with a recent single-clone outbreak in China. This information suggests the possibility of a shifting epidemiological trend of S. pyogenes on the global stage. The information about antibiotic susceptibility patterns and molecular types can help to devise better treatment strategies for S. pyogenes infections, and potentially inform vaccine development. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR] Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1093/ofid/ofz360.305" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofz360.305</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2019 antibiotic resistance antimicrobial susceptibility Bacterial CENTERS for Disease Control & Prevention (U.S.) China clone cells Communicable Diseases Davaadash Bulgan Disclosure Disease Outbreaks DRUG resistance in bacteria Epidemiology Genes ichthyosis Infection Journal Article Kadariya Jhalka low income LOW-income countries Mackey Samantha Medical Molecular MOLECULAR epidemiology Mongolia Morbidity Mortality multi-antibiotic resistance NEOMED College of Medicine Student NEOMED Student Publications November 2019 Update Open forum infectious diseases Polymerase Chain Reaction sequence tagged sites Smith Tara sodium thiosulfate Streptococcus pyogenes surveillance Thapaliya Dipendra TOXIC shock syndrome ULAANBAATAR (Mongolia) vaccine development x-linked