Reduction Of Lipid-laden Macrophage Index After Laparoscopic Nissen Fundoplication In Cystic Fibrosis Patients After Lung Transplantation

Reduction Of Lipid-laden Macrophage Index After Laparoscopic Nissen Fundoplication In Cystic Fibrosis Patients After Lung Transplantation

Hayes D; Kirkby S; McCoy K S; Mansour H M; Khosravi M; Strawbridge H; Tobias J D

Clinical Transplantation

2013

2013-01

Background Lipid-laden macrophage (LLM) index could be potentially useful in assessing gastroesophageal (GE) reflux and aspiration after lung transplantation (LT) in patients with cystic fibrosis (CF). Methods A retrospective review of CF patients undergoing LT and/or laparoscopic Nissen fundoplication (LNF) from January 1, 2009, to December 31, 2011, was performed. Results Seventeen CF patients (nine women), mean (+/- SD) age 27.9 +/- 7.5 yr, underwent LT with mean (+/- SD) pre-transplant FEV1 of 20.9 +/- 5.0% predicted. Seventy percentage (12/17) of patients underwent LNF without complications within 12 wk of LT. After LT, but prior to antireflux surgery, there was no significant difference in the mean (+/- SD) baseline LLM index (154 +/- 41 vs. 146 +/- 51, p = NS) between patients who were to undergo LNF and patients who did not. After LNF, a significant reduction in the mean (+/- SD) LLM index occurred following the procedure (154 +/- 4174 +/- 54, p < 0.0001) while each patient reported resolution of symptoms of GE reflux, whereas 40% (2/5) undergoing only medical treatment reported resolution of symptoms. Conclusions Significant reduction in the LLM index occurred after LNF in CF patients after LT that correlated with resolution of clinical symptoms of GE reflux.

alveolar; aspiration; association; bronchoalveolar lavage fluid; children; chronic rejection; cystic fibrosis; fat-embolism; gastroesophageal reflux; gastroesophageal-reflux disease; laparoscopic; lipid-laden macrophage index; lung; macrophages; marker; Nissen fundoplication; Oil Red O stain; pepsin; pulmonary aspiration; Surgery; transplantation; transplantation

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