Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma

Title

Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma

Creator

Inman D M; Harun-Or-Rashid M

Publisher

Frontiers in Neuroscience

Date

2017
2017-03

Description

Axons can be several orders of magnitude longer than neural somas, presenting logistical difficulties in cargo trafficking and structural maintenance. Keeping the axon compartment well supplied with energy also presents a considerable challenge; even seemingly subtle modifications of metabolism can result in functional deficits and degeneration. Axons require a great deal of energy, up to 70% of all energy used by a neuron, just to maintain the resting membrane potential. Axonal energy, in the form of ATP, is generated primarily through oxidative phosphorylation in the mitochondria. In addition, glial cells contribute metabolic intermediates to axons at moments of high activity or according to need. Recent evidence suggests energy disruption is an early contributor to pathology in a wide variety of neurodegenerative disorders characterized by axonopathy. However, the degree to which the energy disruption is intrinsic to the axon vs. associated glia is not clear. This paper will review the role of energy availability and utilization in axon degeneration in glaucoma, a chronic axonopathy of the retinal projection.

Subject

amyotrophic-lateral-sclerosis; axon; axonopathy; glucose-transporter glut3; glycogen-synthase kinase-3; lactate; Mitochondria; monocarboxylate transporters; mouse white-matter; neuron lactate-shuttle; neuropathy; Neurosciences & Neurology; optic; optic-nerve head; retinal ganglion-cells; self-destruction; slow wallerian degeneration; Wallerian degeneration

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

19-19

Volume

11

Citation

Inman D M; Harun-Or-Rashid M, “Metabolic Vulnerability In The Neurodegenerative Disease Glaucoma,” NEOMED Bibliography Database, accessed September 25, 2021, https://neomed.omeka.net/items/show/10288.

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