Characterization And Performance Of Membranes Designed For Macroencapsulation/implantation Of Pancreatic Islet Cells

Title

Characterization And Performance Of Membranes Designed For Macroencapsulation/implantation Of Pancreatic Islet Cells

Creator

Isayeva I S; Kasibhatla B T; Rosenthal K S; Kennedy J P

Publisher

Biomaterials

Date

2003
2003-09

Description

Amphiphilic polymer membranes were synthesized for macroencapsulation of cells and characterized by select chemical and biological techniques. The membranes were prepared by crosslinking hydrophilic poly(N,N-dimethyl acrylamide) (PDMAAm) main chains with hydrophobic di-, tri-, and octa-methacrylate telechelic polyisobutylene (PIB) stars. The hydrophilic/hydrophobic composition and the molecular weights between crosslink sites (both M-c,M-hydrophilic and M-c,M-hydrophobic) were controlled by synthesis conditions. Small tubular membranes were made by in situ rotational copolymerization/crosslinking and filled with pancreatic rat islets. The water-swelling behavior, mechanical properties, and oxygen and insulin diffusion were studied. Macroencapsulatory performance of these membranes was investigated in vitro by macroencapsulation of pancreatic rat islets within tubular membranes for up to 1.5 months, and studying the insulin secreting ability of encapsulated islets in culture. The membranes are robust and maintain their integrity for the period of encapsulation. They allow oxygen and insulin diffusion. Macroencapsulated islets maintained their viability and insulin secretion over an extended period (i.e., 45 days). (C) 2003 Elsevier Science Ltd. All rights reserved.

Subject

amphiphilic networks; amphiphilic polymer membranes; Engineering; glucose challenge; macroencapsulation of pancreatic islets; macroencapsulatory membranes; Materials Science; oxygen permeability; polyisobutylene; rat; stars

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

3483-3491

Issue

20

Volume

24

Citation

Isayeva I S; Kasibhatla B T; Rosenthal K S; Kennedy J P, “Characterization And Performance Of Membranes Designed For Macroencapsulation/implantation Of Pancreatic Islet Cells,” NEOMED Bibliography Database, accessed January 20, 2021, https://neomed.omeka.net/items/show/10294.

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