Two Generations Of Synthetic Membranes For Biological/medical Applications

Two Generations Of Synthetic Membranes For Biological/medical Applications

Kennedy J P; Rosenthal K S; Kashibhatla B

Designed Monomers and Polymers

2004

2004

Two generations of amphiphilic membranes synthesized in our laboratories for biologicaUniedical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of pancreatic islets and cells, are Summarized. The latter tri-component membranes comprise well-defined hydrophilic poly(ethylene glycol) and hydrophobic/oxyphilic polydimethylsiloxane segments crosslinked by oxyphilic polycyclosiloxane domains, which also provide reinforcement. Select membranes are demonstrated to allow the diffusion of glucose and insulin but prevent the permeation of immunoglobulin G. These membranes remain permeable despite long incubation in IgG solution.

amphiphilic membranes; amphiphilic networks; biocompatibility; diffusion; domains; Glucose; immunoisolation; insulin diffusion; isobutylene; living carbocationic polymerization; membranes; polyisobutylene; Polymer Science; polymers; selective permeability; tricomponent

Journal Article or Conference Abstract Publication

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

485-494

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