The Ability Of The Quadruple Test To Predict Adverse Perinatal Outcomes In A High-risk Obstetric Population

Title

The Ability Of The Quadruple Test To Predict Adverse Perinatal Outcomes In A High-risk Obstetric Population

Creator

Lao M R; Calhoun B C; Bracero L A; Wang Y; Seybold D J; Brace M; Hatjis C G

Publisher

Journal of Medical Screening

Date

2009
2009

Description

`Objective To determine the ability of the quadruple Down's syndrome screening test (quad screen) to predict other adverse perinatal outcomes (APO) in a high-risk obstetric population. Setting A tertiary medical centre in West Virginia. Methods We retrospectively reviewed 342 obstetric patients with quad screen data from a single clinic. The quad screen included maternal serum levels of alphafetoprotein (AFP), human chorionic gonadotrophin (hCG), uncongjugated oestriol (uE(3)) and inhibin A. The risk of APO was compared between patients with at least one abnormal marker versus no abnormal markers and >= 2 abnormal markers versus <2 abnormal markers. Abnormal markers were determined by cut-off values produced by Receiver Operator Characteristic (ROC) curves and the FASTER trial. Unadjusted and adjusted effects were estimated using logistic regression analysis. Results The risk of having an APO increased significantly for patients with abnormal markers by about three-fold using ROC and two-fold using FASTER trial thresholds. Conclusions The quad screen shows value in predicting risk of APO in high-risk patients.

Subject

alpha-fetoprotein; association; birth; down-syndrome; Environmental & Occupational Health; human chorionic-gonadotropin; intrauterine growth restriction; markers; maternal; preeclampsia; pregnancy; Public; serum inhibin

Format

Journal Article or Conference Abstract Publication

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

55-59

Issue

2

Volume

16

Citation

Lao M R; Calhoun B C; Bracero L A; Wang Y; Seybold D J; Brace M; Hatjis C G, “The Ability Of The Quadruple Test To Predict Adverse Perinatal Outcomes In A High-risk Obstetric Population,” NEOMED Bibliography Database, accessed July 27, 2021, https://neomed.omeka.net/items/show/10646.

Social Bookmarking