Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis

Title

Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis

Creator

Byoung-Joon Song; Mohamed A Abdelmegeed; Young-Eun Cho; Mohammed Akbar; Johng S Rhim; Min-Kyung Song; James P Hardwick

Publisher

Human Cell Transformation : Advances In Cell Models For The Study Of Cancer And Aging

Date

2019
1905-07

Description

The purpose of this review is to briefly summarize the roles of alcohol (ethanol) and related compounds in promoting cancer and inflammatory injury in many tissues. Long-term chronic heavy alcohol exposure is known to increase the chances of inflammation, oxidative DNA damage, and cancer development in many organs. The rates of alcohol-mediated organ damage and cancer risks are significantly elevated in the presence of co-morbidity factors such as poor nutrition, unhealthy diets, smoking, infection with bacteria or viruses, and exposure to pro-carcinogens. Chronic ingestion of alcohol and its metabolite acetaldehyde may initiate and/or promote the development of cancer in the liver, oral cavity, esophagus, stomach, gastrointestinal tract, pancreas, prostate, and female breast. In this chapter, we summarize the important roles of ethanol/acetaldehyde in promoting inflammatory injury and carcinogenesis in several tissues. We also review the updated roles of the ethanol-inducible cytochrome P450-2E1 (CYP2E1) and other cytochrome P450 isozymes in the metabolism of various potentially toxic substrates, and consequent toxicities, including carcinogenesis in different tissues. We also briefly describe the potential implications of endogenous ethanol produced by gut bacteria, as frequently observed in the experimental models and patients of nonalcoholic fatty liver disease, in promoting DNA mutation and cancer development in the liver and other tissues, including the gastrointestinal tract.

Subject

inflammation; Oxidative stress; Cancer; CYP2E1; Cell Biology; Oncology; Alcohol; Acetaldehyde; Biomedical and Life Sciences; Cancer Research; DNA mutation; Life Sciences

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

73

ISSN

3-030-22254-3

Citation

Byoung-Joon Song; Mohamed A Abdelmegeed; Young-Eun Cho; Mohammed Akbar; Johng S Rhim; Min-Kyung Song; James P Hardwick, “Contributing Roles of CYP2E1 and Other Cytochrome P450 Isoforms in Alcohol-Related Tissue Injury and Carcinogenesis,” NEOMED Bibliography Database, accessed August 3, 2021, https://neomed.omeka.net/items/show/10857.

Social Bookmarking