The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.
Title
The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.
Creator
Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten
Publisher
Kidney diseases (Basel, Switzerland)
Date
2020
2020-01
Description
Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining renal perfusion and controls glomerular arteriole tone and hemodynamics. It is hypothesized that
Subject
Focal segmental glomerulosclerosis; Diabetic nephropathy; Endothelin; Endothelin antagonists; Hypertensive nephropathy
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
Journal Article
URL Address
Search for Full-text
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Pages
22-34
Issue
1
Volume
6
NEOMED College
NEOMED College of Graduate Studies; NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Update Year & Number
March 2020 Update
Citation
Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten, “The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.,” NEOMED Bibliography Database, accessed April 26, 2025, https://neomed.omeka.net/items/show/10979.