The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Title

The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.

Creator

Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten

Publisher

Kidney diseases (Basel, Switzerland)

Date

2020
2020-01

Description

Background: Endothelins (ET) are a family of peptides that act as potent vasoconstrictors and pro-fibrotic growth factors. ET-1 is integral to renal and cardiovascular pathophysiology and exerts effects via autocrine, paracrine and endocrine signaling pathways tied to regulation of aldosterone, catecholamines, and angiotensin. In the kidney, ET-1 is critical to maintaining renal perfusion and controls glomerular arteriole tone and hemodynamics. It is hypothesized that

Subject

Focal segmental glomerulosclerosis; Diabetic nephropathy; Endothelin; Endothelin antagonists; Hypertensive nephropathy

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

22-34

Issue

1

Volume

6

NEOMED College

NEOMED College of Graduate Studies; NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications

Update Year & Number

March 2020 Update

Citation

Raina Rupesh; Chauvin Abigail; Chakraborty Ronith; Nair Nikhil; Shah Haikoo; Krishnappa Vinod; Kusumi Kirsten, “The Role of Endothelin and Endothelin Antagonists in Chronic Kidney Disease.,” NEOMED Bibliography Database, accessed September 21, 2021, https://neomed.omeka.net/items/show/10979.

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