Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.

Title

Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.

Creator

Ahmad Nashrah; Ansari Mohammad Y; Haqqi Tariq M

Publisher

Journal of cellular physiology

Date

2020
2020-02

Description

Accumulating evidence suggests that inflammation has a key role in the pathogenesis of osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory mediators in OA and drives many pathological changes during the development and progression of OA. Excessive production of NO in chondrocytes promotes cartilage destruction and cellular injury. The synthesis of NO in chondrocytes is catalyzed by inducible NO synthase (iNOS), which is thereby an attractive therapeutic target for the treatment of OA. A number of direct and indirect iNOS inhibitors, bioactive compounds, and plant-derived small molecules have been shown to exhibit chondroprotective effects by suppressing the expression of iNOS. Many of these iNOS inhibitors hold promise for the development of new, disease-modifying therapies for OA; however, attempts to demonstrate their success in clinical trials are not yet successful. Many plant extracts and plant-derived small molecules have also shown promise in animal models of OA, though further studies are needed in human clinical trials to confirm their therapeutic potential. In this review, we discuss the role of iNOS in OA pathology and the effects of various iNOS inhibitors in OA.

Subject

chondrocytes; osteoarthritis; iNOS; oxidative stress; inflammation; nitric oxide; iNOS inhibitor

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

Journal Article

Search for Full-text

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NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Anatomy & Neurobiology

Update Year & Number

March 2020 Update

Citation

Ahmad Nashrah; Ansari Mohammad Y; Haqqi Tariq M, “Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.,” NEOMED Bibliography Database, accessed January 23, 2021, https://neomed.omeka.net/items/show/11004.

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